Relationship of high‐density lipoprotein subfractions and apolipoprotein A‐I with fat in the pancreas DOI Creative Commons
Yutong Liu, Xiatiguli Shamaitijiang, Loren Skudder‐Hill

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Aim To investigate the associations of high‐density lipoprotein (HDL) subfractions and apolipoprotein A‐I (apo A‐I) with fat in pancreas. Methods A total 170 individuals were studied. All participants underwent magnetic resonance imaging on a single 3.0‐Tesla scanner to determine presence/absence fatty HDL measured using commercially available testing system classed as large, intermediate small HDL. Both unadjusted adjusted (accounting for demographics, anthropometrics, insulin resistance other covariates) logistic regression models built. Results Individuals pancreas had significantly lower circulating levels large class apo A‐I. Every unit decrease was associated 93% increase likelihood most model ( P < .001). 45% = .012). The classes not Conclusions Fat is inversely particles Purposely designed studies are warranted potential an indicator risk cardiovascular diseases.

Language: Английский

Relationship of fat in the pancreas with cardiovascular disease: A systematic review and meta‐analysis DOI Creative Commons
Yingxin Zhang, Yutong Liu, Maxim S. Petrov

et al.

Obesity Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Summary Background General adiposity is a well‐known risk factor for cardiovascular disease. By contrast, the interconnection between high intra‐pancreatic fat deposition and disease has been scantily investigated. This field‐wide systematic review aimed to map available evidence on according content of pancreas. Methods A literature search using two electronic databases (MEDLINE Embase) was conducted independently by reviewers. Studies reporting association in humans were included. Where meta‐analysis possible, data pooled random‐effects method. Results total 16 studies published 1966 2024 The most credible findings across domains heart diseases, diseases arteries, arterioles, capillaries, as well subclinical atherosclerosis provided supportive positive relationship Meta‐analysis showed that significantly associated with increased aortic intima‐media thickness (mean difference: 0.19 mm; 95% confidence interval: 0.12–0.26; p < 0.001), carotid 0.06 0.03–0.08; vascular stiffness 167 cm/s; 81–254; 0.001). Conclusion accumulated from more than 7000 people demonstrates tangible connection (especially, atherosclerosis). Purposely designed investigations an additional (independent general adiposity) are warranted.

Language: Английский

Citations

1
The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat DOI Creative Commons
Loren Skudder‐Hill, Ivana R. Sequeira, Juyeon Ko

et al.

Obesity, Journal Year: 2024, Volume and Issue: 32(12), P. 2310 - 2320

Published: Nov. 10, 2024

Abstract Objective Previous studies have investigated the association between hepatic fat and intrapancreatic deposition (IPFD); however, results been inconclusive. The presence of cardiometabolic factors in certain subpopulations could explain this discrepancy. aim present study was to use moderation analyses determine conditions under which is associated with IPFD. Methods All participants underwent 3T abdominal magnetic resonance imaging (MRI) spectroscopy. Hepatic IPFD were manually quantified by independent raters. Moderation performed adjustment for sex ethnicity. Results There 367 included. Adjusted overall cohort revealed that age, glycated hemoglobin (HbA 1c ), low‐density lipoprotein cholesterol (LDL‐C), high‐density (HDL‐C), triglycerides significant moderators ( p < 0.05) Ranges significance included age 61 years, HbA 45 mmol/mol, LDL‐C 157 mg/dL, HDL‐C > 36 203 mg/dL. Conclusions generally young middle‐aged adults good health, whereas link two depots becomes uncoupled older or individuals risk factors. image

Language: Английский

Citations

5
Associations of intra‐pancreatic fat deposition with triglyceride‐rich lipoproteins and lipoprotein lipase DOI Creative Commons
Yutong Liu, Loren Skudder‐Hill, Wandia Kimita

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Aims To investigate the associations of intra‐pancreatic fat deposition (IPFD) with very‐low‐density lipoprotein (VLDL), intermediate‐density (IDL) and lipase. Materials methods A total 174 participants underwent magnetic resonance imaging on a 3.0 Tesla scanner for quantification IPFD. Blood samples were collected following an 8‐h fasting period. Triglyceride‐rich lipoproteins measured using Lipoprint® system classed as VLDL, IDL‐C, IDL‐B IDL‐A subfractions. Lipoprotein lipase was ELISA. Univariable multivariable linear regression analyses conducted. Results Both IPFD significantly associated levels in most adjusted model. Specifically, each unit increase 0.12‐unit ( p = 0.047) whereas 0.22‐unit 0.015). Neither nor VLDL. Conclusions The relationship triglyceride‐rich differs depending nature lipoproteins. High is increased IDL (specifically, its representative subfraction—IDL‐B), but not Fatty pancreas disease may contribute to increasing risk atherosclerotic CVD through IDL.

Language: Английский

Citations

0
The Effects of Metabolic Bariatric Surgery on Intra-pancreatic Fat Deposition and Total Pancreas Volume: a Systematic Review and Meta-analysis DOI Creative Commons
Yaochen Wang, Yutong Liu, Maxim S. Petrov

et al.

Obesity Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Bariatric procedures are common interventions for weight loss and metabolic improvements; yet, their effects on the pancreas—a key organ—are largely unknown. This systematic review aimed to summarise data changes in intra-pancreatic fat deposition (IPFD) total pancreas volume (TPV) following bariatric surgery endoscopic therapy. The literature search was conducted MEDLINE Embase databases. Studies humans were included if they reported IPFD and/or TPV from before after procedure. Random meta-analysis conducted. Fourteen studies (all involving surgery) met eligibility criteria. Metabolic resulted a mean absolute reduction of 3.9% ( p = 0.003) decrease 10.7 cm 3 < 0.001). relative 35.9%. Sleeve gastrectomy led higher than Roux-en-Y gastric bypass (39.9% vs. 20.6%), though this difference not statistically significant. Analysis follow-up duration showed 8.8% patients with follow-ups less months. leads significant reductions TPV. Follow-up should take place no earlier months full benefits manifest.

Language: Английский

Citations

0
Relationship of high‐density lipoprotein subfractions and apolipoprotein A‐I with fat in the pancreas DOI Creative Commons
Yutong Liu, Xiatiguli Shamaitijiang, Loren Skudder‐Hill

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Aim To investigate the associations of high‐density lipoprotein (HDL) subfractions and apolipoprotein A‐I (apo A‐I) with fat in pancreas. Methods A total 170 individuals were studied. All participants underwent magnetic resonance imaging on a single 3.0‐Tesla scanner to determine presence/absence fatty HDL measured using commercially available testing system classed as large, intermediate small HDL. Both unadjusted adjusted (accounting for demographics, anthropometrics, insulin resistance other covariates) logistic regression models built. Results Individuals pancreas had significantly lower circulating levels large class apo A‐I. Every unit decrease was associated 93% increase likelihood most model ( P < .001). 45% = .012). The classes not Conclusions Fat is inversely particles Purposely designed studies are warranted potential an indicator risk cardiovascular diseases.

Language: Английский

Citations

3