Does Long-term Surveillance Imaging Improve Survival in Patients Treated for Head and Neck Squamous Cell Carcinoma? A Systematic Review of the Current Evidence DOI
Pattana Wangaryattawanich, Yoshimi Anzai, Carolyn Mead‐Harvey

et al.

American Journal of Neuroradiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

ABSTRACT

BACKGROUND:

Long-term post-treatment surveillance imaging algorithms for head and neck squamous cell carcinoma are not standardized due to debates over optimal strategy efficacy. Consequently, current guidelines do provide long-term recommendations beyond 6 months.

PURPOSE:

We performed a systematic review evaluate the impact of (i.e., months following treatment completion) on survival in patients treated definitively carcinoma.

DATA SOURCES:

A search was conducted PubMed, Embase, Scopus, Cochrane Central Register Controlled Trials, Web Science English literature published between 2003 2024 evaluating with

STUDY SELECTION:

718 abstracts were screened 95 underwent full-text review, 2 articles meeting inclusion criteria. The Risk Bias Non-randomized Studies Interventions assessment tool used. ANALYSIS: qualitative without pooled analysis two studies SYNTHESIS: No randomized prospective controlled trials identified. Two retrospective two-arm included comparing clinical each rated as having moderate risk bias. Each study heterogeneous populations variable profiles protocols. Both investigated overall came different conclusion one reporting benefit FDG PET/CT stage III or IV disease an oropharyngeal primary tumor other demonstrating no benefit.

LIMITATIONS:

Limited data available precludes definitive conclusions

CONCLUSIONS:

There is insufficient quality evidence regarding lack definition surveillance, protocols, inconsistencies results reporting, underscoring need multi-center registry assessing outcomes. ABBREVIATIONS: HNSCC = Head Neck Squamous Cell Carcinoma; RT= radiotherapy; NCCN National Comprehensive Cancer Network; MPC metachronous cancer; CR complete response; OS survival; CRT chemoradiotherapy; HPV human papillomavirus; PFS progression-free CFU follow up; NI-RADS Imaging Reporting Data System.

Language: Английский

Emerging Proximal Liquid Biopsy Approaches for Detecting Residual Disease and Predicting Recurrence in Head and Neck Cancer: A Review and Proposal of Novel Liquid Staging DOI Creative Commons

Vanessa Helou,

Joshua D. Smith, Micah Harris

et al.

Head & Neck, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Head and neck squamous cell carcinoma remains challenging due to high recurrence rates poor survival outcomes. Developing precise technologies for disease burden assessment, treatment response, minimal residual (MRD) surveillance is crucial improving prognosis. This review explores the potential of liquid biopsy MRD detection. A novel TNM (LiTNM) staging system introduced, integrating biomarkers from saliva, surgical drain lymphatic fluid (SLF), peripheral blood. Proximal biopsies, particularly saliva SLF, offer advantages their proximity tumor microenvironment. Saliva demonstrates sensitivity in HPV-associated oropharyngeal cancers, while SLF holds identifying early postoperative recurrence. Despite these advancements, standardization validation remain challenges. Liquid approaches show promise monitoring, yet clinical implementation stages. The proposed LiTNM could complement by providing a molecular framework risk stratification. However, rigorous prospective studies are necessary validate its utility facilitate adoption.

Language: Английский

Citations

0
The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine DOI Open Access

Sami I. Nassar,

Amber Suk,

Shaun A. Nguyen

et al.

Published: Aug. 21, 2024

Recent data has shown a continued rise in the worldwide annual incidence and mortality rates of head neck cancers. The present standard for diagnosis monitoring disease recurrence or progression involves clinical examination, imaging, invasive biopsy techniques lesions suspected being malignant. In addition to limitations relating cost, time, patient discomfort, these methodologies have inherent inaccuracies detecting recurrence. view limitations, analysis bodily fluid samples via liquid proposes cost-effective convenient alternative, which provides insight on biogenetic biomolecular underpinnings oncologic processes. Liquid biopsy’s biomarkers cancer, including circulating tumor DNA, cells, cell-free RNA, utility screening, diagnosis, prognostication, patients with various forms cancer. review will provide an update current literature examining use cancer care applicability potential biomarkers, focus viral non-viral DNA. Possible future avenues research address specific shortcomings be discussed.

Language: Английский

Citations

1
The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine DOI Open Access

Sami I. Nassar,

Amber Suk,

Shaun A. Nguyen

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3129 - 3129

Published: Sept. 11, 2024

Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head neck cancers. The present standard for diagnosis monitoring disease recurrence or progression involves clinical examination, imaging, invasive biopsy techniques lesions suspected being malignant. In addition to limitations relating cost, time, patient discomfort, these methodologies inherent inaccuracies detecting recurrence. view limitations, analysis bodily fluid samples via liquid proposes cost-effective convenient alternative, which provides insight on biogenetic biomolecular underpinnings oncologic processes. biomarkers cancer biopsy, including circulating tumor DNA, cells, cell-free RNA, has utility screening, diagnosis, prognostication, patients with various forms cancer. review will provide an update current literature examining use care applicability potential biomarkers, focus viral non-viral DNA. Possible future avenues research address specific shortcomings be discussed.

Language: Английский

Citations

1
Does Long-term Surveillance Imaging Improve Survival in Patients Treated for Head and Neck Squamous Cell Carcinoma? A Systematic Review of the Current Evidence DOI
Pattana Wangaryattawanich, Yoshimi Anzai, Carolyn Mead‐Harvey

et al.

American Journal of Neuroradiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

ABSTRACT

BACKGROUND:

Long-term post-treatment surveillance imaging algorithms for head and neck squamous cell carcinoma are not standardized due to debates over optimal strategy efficacy. Consequently, current guidelines do provide long-term recommendations beyond 6 months.

PURPOSE:

We performed a systematic review evaluate the impact of (i.e., months following treatment completion) on survival in patients treated definitively carcinoma.

DATA SOURCES:

A search was conducted PubMed, Embase, Scopus, Cochrane Central Register Controlled Trials, Web Science English literature published between 2003 2024 evaluating with

STUDY SELECTION:

718 abstracts were screened 95 underwent full-text review, 2 articles meeting inclusion criteria. The Risk Bias Non-randomized Studies Interventions assessment tool used. ANALYSIS: qualitative without pooled analysis two studies SYNTHESIS: No randomized prospective controlled trials identified. Two retrospective two-arm included comparing clinical each rated as having moderate risk bias. Each study heterogeneous populations variable profiles protocols. Both investigated overall came different conclusion one reporting benefit FDG PET/CT stage III or IV disease an oropharyngeal primary tumor other demonstrating no benefit.

LIMITATIONS:

Limited data available precludes definitive conclusions

CONCLUSIONS:

There is insufficient quality evidence regarding lack definition surveillance, protocols, inconsistencies results reporting, underscoring need multi-center registry assessing outcomes. ABBREVIATIONS: HNSCC = Head Neck Squamous Cell Carcinoma; RT= radiotherapy; NCCN National Comprehensive Cancer Network; MPC metachronous cancer; CR complete response; OS survival; CRT chemoradiotherapy; HPV human papillomavirus; PFS progression-free CFU follow up; NI-RADS Imaging Reporting Data System.

Language: Английский

Citations

0