Biomimetic niosomal versus liposomal nanoparticle-based aspirin injection for treating stroke and myocardial infarction DOI Creative Commons

Bhavana Raj,

Harika Sapa,

Shona Sara Shaji

et al.

Journal of Biomaterials Applications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

In this work, we are comparing biomimetic niosomal nanoparticles (BNNs) with liposomal (BLNs) and studying their drug carrier properties. A-BNNs A-BLNs prepared by lipid hydration method characterized using DLS for size zeta potential analysis, surface morphology SEM, structural details TEM, crystallinity phase change XRD, thermodynamic properties DSC, TGA DTGA, entrapment efficiency, release studies open-end tube its mechanistic assessment fitting various models such as zero order, first Higuchi Korsmeyer-Peppas models. The had an average of 157.0 ± 3.58 nm 173 1.24 nm. -29.0 1.11 mV -46.5 mV. have efficiency 94 0.4% 98 0.14%. BNNs 78.12 1.57% 98.41 1.87% over 24 hours. Our results show that the vesicular dependence influences resulting nanoparticle This is a robust demonstration phenomena at nanoscale precursor system dependency will be reflected in bulk-engineered These novel candidates development injection to suppress clots stroke myocardial infarction.

Language: Английский

Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review DOI
Jinjin Pei, Chella Perumal Palanisamy, Prabhu Manickam Natarajan

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102393 - 102393

Published: June 24, 2024

Language: Английский

Citations

10
Comprehensive investigation of niosomal red palm wax gel encapsulating ginger (Zingiber officinale Roscoe): Network pharmacology, molecular docking, In vitro studies and phase 1 clinical trials DOI
Tassanee Ongtanasup,

Weeratian Tawanwongsri,

Chawan Manaspon

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134334 - 134334

Published: July 31, 2024

Language: Английский

Citations

6
Investigation of Flurbiprofen Pharmacokinetics in Rats Following Dermal Administration of Optimized Cyclodextrin-Based Nanogel DOI Creative Commons
Ayşe Nur Oktay, Nevin Çelebi, Sibel Ilbasmiş-Tamer

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 206, P. 107021 - 107021

Published: Jan. 18, 2025

The main purpose of this study was to optimize a cyclodextrin-based nanogel flurbiprofen (FP) for prolonged dermal administration and evaluate its stability, in vitro release, ex vivo skin permeation, pharmacokinetic profile. nanogels were prepared via emulsification/solvent evaporation process optimized through design experiments. Optimal formulation characterized particle size (PS), polydispersity index (PDI), zeta potential (ZP), differential scanning calorimetry (DSC) X-ray powder diffraction (XRPD), solubility, release/ex permeation studies mathematical modeling, conducted rats. Results compared HPMC-based gel that not nano-sized (i.e.FP-HPMC gel). PS, PDI ZP values optimal FP-loaded 295.5 nm, 0.361 -31.9 mV, respectively it stable 12 months. In release studies, the flux from (96.3 µg/hcm2) three times slower (i.e.more controlled) than FP-HPMC (287 µg/hcm2); permeability coefficient (0.015 cm/h) slightly less (0.046 cm/h). Rat showed provided higher drug retention skin, gel. Mathematical modeling rat Hixson-Crowell model best fitting nanogel, suggesting surface area is changing during process. FB-loaded exhibited flatter plasma profile gel, consistent with skin. more sustained performance

Language: Английский

Citations

0
Multifunctional liposomal gel in regenerative medicine DOI

Meghna Mohandas,

R. Jayakumar

Journal of Liposome Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 19, 2025

The synergistic approach of liposome integrated with gel matrix could reshape the current frameworks drug delivery technology. liposome-based approaches are limited by inadequate stability and rapid leakage molecules. Undesired immediate release from increases local concentration causes toxicity. So, stabilization liposomes within a can be an effective option to provide ingenious solution conventional limitation on short half-life, instability, toxicity, uncontrolled poor retention molecules target site. capability incorporate antibacterial as well anti-oxidant drugs, antimicrobial peptides, ligands, growth hormones, antigens, imaging agents had contributed establishment multifunctional liposomal system has significant advantage in regenerative medicine area. This review will focus gels context infectious wound healing, skin rejuvenation, musculoskeletal repair trauma management, spinal cord injury treatment, tumor specific chemotherapy immunotherapy vaccination. versatility executing multiple functions valuable for advancing therapeutic outcomes medicine.

Language: Английский

Citations

0
Niosomes: A Revolution in Sustainable and Targeted Drug Delivery-Green Synthesis, Precision Medicine, and Beyond DOI

Harsh Pirojiya,

Kiran Dudhat

Regenerative Engineering and Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский

Citations

3
Harnessing Cu- and Fe-Based Metal-Organic Frameworks as Innovative Nanocarriers for Enhanced Fluconazole Delivery in Topical Management of Candida albicans DOI
Mrunali R. Patel,

Jigisha Panchal,

Richa Dave

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106854 - 106854

Published: March 1, 2025

Language: Английский

Citations

0
Advances in synthetic strategies and applications of polymeric hydrogels DOI

Bharat Gajurel,

K. Tamang,

Dipankar Das

et al.

Polymer Engineering and Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Hydrogels are three‐dimensional networks of hydrophilic polymers capable absorbing and retaining a significant amount water while maintaining their structural integrity. Their biocompatibility, tunable physical characteristics, resemblance to the extracellular matrix make them highly versatile in biomedical engineering. This paper provides comprehensive overview hydrogels, covering historical development, classification, synthetic fabrication strategies tailored for specific applications. widespread use spans biomedical, industrial, environmental fields, driven by high retention, responsiveness external stimuli. In biomedicine, hydrogels play crucial role drug delivery, wound healing, tissue engineering, biosensing, bioprinting, with applications extending cardiac regeneration neural growth. Additionally, they function as smart materials sensors actuators contribute advancements flexible electronics energy storage. Finally, current trends, challenges, opportunities hydrogel have been summarized. Highlights New (HG) elucidated. Enhanced biocompatibility boosts HG life sciences. haspotential uses field, controlled delivery release. Advanced HGs characteristics needed various

Language: Английский

Citations

0
Weaving the gates of life: Pioneering a new era in oral gene delivery with metal-organic frameworks DOI
Min Jiang, Guohui Zhang, Qin Zeng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158522 - 158522

Published: Dec. 10, 2024

Language: Английский

Citations

1
Biomimetic niosomal versus liposomal nanoparticle-based aspirin injection for treating stroke and myocardial infarction DOI Creative Commons

Bhavana Raj,

Harika Sapa,

Shona Sara Shaji

et al.

Journal of Biomaterials Applications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

In this work, we are comparing biomimetic niosomal nanoparticles (BNNs) with liposomal (BLNs) and studying their drug carrier properties. A-BNNs A-BLNs prepared by lipid hydration method characterized using DLS for size zeta potential analysis, surface morphology SEM, structural details TEM, crystallinity phase change XRD, thermodynamic properties DSC, TGA DTGA, entrapment efficiency, release studies open-end tube its mechanistic assessment fitting various models such as zero order, first Higuchi Korsmeyer-Peppas models. The had an average of 157.0 ± 3.58 nm 173 1.24 nm. -29.0 1.11 mV -46.5 mV. have efficiency 94 0.4% 98 0.14%. BNNs 78.12 1.57% 98.41 1.87% over 24 hours. Our results show that the vesicular dependence influences resulting nanoparticle This is a robust demonstration phenomena at nanoscale precursor system dependency will be reflected in bulk-engineered These novel candidates development injection to suppress clots stroke myocardial infarction.

Language: Английский

Citations

0