Moringa
oleifera,
commonly
known
as
the
tree,
has
garnered
considerable
attention
in
recent
years
due
to
its
abundant
phytochemical
composition
with
potential
medicinal
and
nutritional
benefits.
This
literature
review
presents
a
comprehensive
exploration
of
interplay
between
computational
analysis,
predictive
modeling,
richness
aiming
elucidate
applications
medicine
nutrition.
The
comprising
flavonoids,
phenolic
compounds,
vitamins,
minerals,
other
bioactive
constituents,
forms
foundation
this
investigation.
Computational
methods,
including
molecular
docking,
quantitative
structure-activity
relationship
(QSAR)
chemoinformatics,
are
scrutinized
for
their
role
characterizing
predicting
bioactivity
oleifera
phytochemicals.
Predictive
modeling
techniques,
encompassing
machine
learning
algorithms
regression
evaluated
utility
forecasting
bioactivity,
toxicity,
properties
these
Through
synergy
approaches,
researchers
gain
insights
into
underscores
significance
relationships
data-driven
designing
targeted
interventions.
It
also
highlights
promising
prospects
drug
development,
functional
foods,
dietary
supplements
derived
from
oleifera.
While
progress
been
made,
opportunities
remain
address
research
gaps,
refine
models,
translate
findings
practical
that
promote
human
health
provides
foundational
understanding
transformative
analysis
harnessing
wealth
opening
new
avenues
interdisciplinary
pursuit
advancements.
The Journal of Contemporary Dental Practice,
Journal Year:
2022,
Volume and Issue:
22(12), P. 1483 - 1492
Published: April 20, 2022
Moringa
oleifera
(MO),
or
the
common
drumstick
possesses
antioxidant
properties,
and
its
pods,
seeds,
leaves,
bark
have
been
used
for
treatment
of
inflammatory
cancerous
conditions.
This
systematic
review
attempts
to
synthesize
original
studies
MO
extracts
in
cell
lines
determine
their
specific
antiproliferative,
antioxidant,
anti-inflammatory,
related
effects.
The
literature
was
obtained
from
PubMed
central,
Cochrane
registry,
other
sources
including
Google
Scholar,
Embase.
Studies
fulfilling
inclusion
criteria
were
selected.
Custom
data
collection
forms
employed
two
independent
evaluators
compiled
relevant
information.
Eighteen
selected
after
applying
exclusion
criteria.
In
most
studies,
leaves
had
more
potent
properties
compared
parts
plant.
Ethyl
acetate
ethanolic
extractions
improved
potency
extract.
Effects
selective
(different
normal
cells
cancer
cells)
dose-dependent.
Anticancer
activities
consistently
reported,
with
effects
exerted
at
genetic
molecular
levels.
potentially
could
be
therapeutic
applications.
optimal
sources,
preparation
protocols,
dosages
researched,
though
further
scrutiny
is
needed
a
comprehensive
formulation.
Keywords:
Anticancer,
Anti-inflammatory,
Antioxidant,
oleifera.
Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(6), P. 104755 - 104755
Published: March 2, 2023
In
this
study,
a
fingerprint-activity
relationship
between
ultrahigh
performance
liquid
chromatography
(UHPLC)
fingerprints
and
antioxidant
activity
was
established
to
evaluate
the
quality
of
Aster
yunnanensis
Franch.(AYF)
from
different
collecting
spots.
First,
fingerprint
AYF
by
UHPLC,
similarity
analysis
analyzed
based
on
twenty-one
common
peaks.
Then
chemical
constituents
were
identified
UHPLC-quadrupole
time-of-flight
tandem
mass
spectrometry
(QTOF-MS/MS).
Next,
twelve
batches
assessed
in
vitro.
Subsequently,
eleven
markers
screened
out
utilizing
grey
relational
(GRA)
partial
least
squares
(PLS).
Finally,
contents
detected
evaluated
using
chemometric
analysis,
such
as
principal
components
(PCA)
technique
for
order
preference
ideal
solution
(TOPSIS).
The
results
showed
that
efficacy
associated
with
total
content
compounds
AYF.
Moreover,
method
discover
reasonable
combination
analysis.
present
study
will
certify
therapeutic
effects,
provide
powerful
strategy
evaluating
resource
Food Reviews International,
Journal Year:
2023,
Volume and Issue:
40(2), P. 740 - 770
Published: March 27, 2023
Moringa
oleifera
Lam.
(M.
oleifera)
is
a
fast-growing
and
esculent
plant
with
high
nutritional
medicinal
values.
Traditionally,
M.
has
been
applied
to
treat
anaemia,
asthma,
pain
in
joints,
headaches,
diarrhoea
so
forth.
Phytochemical
studies
have
manifested
that
more
than
300
components,
including
flavonoids,
phenolic
acids,
organic
alkaloids,
lignans,
glucosinolates,
carotenoids,
proteins,
fats,
minerals,
on,
are
present
different
parts
of
oleifera.
Simultaneously,
exhibited
extensive
notable
pharmacological
activities,
such
as
antioxidant,
anti-inflammatory,
antimicrobial,
anti-cancer,
hypoglycemic,
hypolipidemic,
hypotensive,
hepatoprotective,
etc.
Consequently,
on
the
one
hand,
this
work
aims
comprehensively
holistically
review
chemical
constituents
activities
various
oleifera,
well
its
applications
functional
food
products
medicines.
On
other
also
looks
forward
new
prospects
future
developments
research
thus
provides
valuable
insights
for
follow-up
in-depth
multifunctional
tree.
Nutrition and Cancer,
Journal Year:
2023,
Volume and Issue:
75(10), P. 1822 - 1847
Published: Oct. 18, 2023
Hepatocellular
carcinoma
(HCC)
is
the
most
prevalent
primary
liver
cancer
in
Sub-Saharan
African
countries,
including
South
Africa
(SA).
Given
limitations
current
HCC
therapeutics,
there
an
increasing
need
for
alternative
adjuvant
therapeutic
options.
As
such,
several
cell
survival
mechanisms,
such
as
autophagy,
have
been
identified
potential
targets
treatment.
Of
three
established
autophagic
pathways,
upregulation
of
chaperone-mediated
autophagy
(CMA)
has
extensively
described
various
cells,
cells.
CMA
promotes
tumor
growth
and
chemotherapeutic
drug
resistance,
thus
contributing
to
tumorigenesis.
Therefore,
modulation
serves
a
promising
target
strategies.
Phytochemical
extracts
found
medicinal
plant,
Technology audit and production reserves,
Journal Year:
2024,
Volume and Issue:
2(3(76)), P. 48 - 52
Published: April 30, 2024
The
object
of
the
study
is
process
purifying
natural
waters
using
coagulants
and
industrial
origin.
subject
analysis
effectiveness
Today,
there
great
interest
in
finding
alternative
methods
water
purification
that
would
be
more
economical
environmentally
friendly.
availability
clean
safe
especially
important
during
times
martial
law.
Coagulants
origin
can
an
affordable
effective
means
disinfection.
One
advantages
availability,
which
indicates
possibility
becoming
to
chemical
coagulants.
Thus,
a
need
both
on
scale
emergency
conditions.
This
presents
characterization
existing
origin,
their
use,
comparison
with
analogues,
as
well
Moringa
oleifera
coagulant.
During
work,
two
were
synthesized
from
red
mud
aluminium
production.
A
comparative
mud,
oleifera,
aquatone
sulphate
was
carried
out.
All
reagents
used
remove
turbidity
other
impurities.
studies
out
3
different
seasons
year.
results
compared
determine
most
coagulant
its
dose.
As
result,
it
found
all
these
reduce
treatment
costs
at
local
plants.
areas
where
no
access
central
supply,
war
zones.
Egyptian Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
0(0), P. 0 - 0
Published: May 19, 2021
Cypermethrin
(CYP)
is
a
popular
environmental
toxicant
because
of
its
wide-ranging
use
as
broad-band
insecticide.The
purpose
this
research
was
to
explore
the
potential
impact
Moringa
oleifera
leaves
extract
(MOLE)
protective
agent
against
cypermethrin-induced
lung
toxicity
in
male
albino
rats.Forty
experimental
animals
were
allocated
into
four
groups.G1
served
negative
control,
G2,
G3
and
G4
orally
treated
with
MOLE
(250
mg/kg
body
weight),
CYP
(26.15mg/kg
weight)
+
MOLE,
respectively.CYP
oral
administration
for
28
days
elevated
levels
oxidative
stress
biomarkers
like
Malondialdehyde,
superoxide
dismutase,
catalase
glutathione
S-transferase
caused
decline
content
reduced
tissue
rats.Lung
injury
verified
by
histopathological
changes
evidenced
interstitial
pneumonia,
marked
perivasculitis,
focal
pulmonary
hemorrhage,
haemosidrosis
edema
CYP-exposed
rats.Co-administration
mitigated
induced
alterations.As
result,
can
prevent
due
free
radical
scavenging
antioxidant
properties.
Moringa
oleifera,
a
naturally
growing
plant
in
South
Africa,
has
been
reported
to
have
antioxidant
properties,
bioactive
chemical
constituents,
and
outstanding
nutritional
value.
However,
insufficient
scientific
information
supports
these
assertions
on
its
activity
against
tyrosinase.
Therefore,
this
review
aims
at
characterising
determining
the
phenolic
composition
of
acetone
(MOAC),
aqueous
(MOAQ),
ethanol
(MOET)
methanol
(MOME)
extracts
oleifera
leaf
powder
(MOLP)
based
structure
functionality.
It
also
establishing
50%
inhibitory
concentration
(IC50)
different
tyrosinase
enzyme.
A
liquid
chromatograph-mass
spectrometry
(LC-MS)
was
used
characterise
phytocompounds
from
(MOLP).
The
1,1-Diphenyl-2-picryl-hydrazyl
(DPPH),
ferric-reducing
power
assay
(FRAP),
2,2`-azino-di-3-ethylbenzthialozine
sulphonate
(ABTS)
oxygen
radical
absorbance
capacity
(ORAC)
assays
were
determine
activities
MOLP
extracts.
anti-tyrosinase
determined
using
microplate
reader
with
kojic
acid
as
positive
control.
total
22
phytochemicals
including
flavonoids,
acids,
amino
quinones
fatty
acids
identified
all
There
high
content
flavonoids
particular
such
rutin,
isoquercitrin,
hyperoside
others.
MOET
MOME
showed
significantly
higher
(p
<
0.05)
than
MOAC
MOAQ
IC50
for
ranged
34.66
(MOAQ)
71.29
µg/mL
(MOET).
stronger
inhibition
may
be
associated
presence
compounds
flavonoids.
is
potent
anti-browning
agent
can
various
dried
fruits
preservative.
Journal of Food Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 28, 2024
Abstract
The
effect
of
solvents
with
different
polarities
on
the
recovery
phytochemicals
(carotenoids,
capsaicinoids,
and
phenolic
compounds)
from
habanero
pepper
(
Capsicum
chinense
)
their
association
antioxidant
activity
(ABTS
•+
DPPH)
was
evaluated
through
Ultra‐Performance‐Liquid
Chromatography
coupled
a
Photodiode
Array
Detector
Electrospray
Ionization
Mass
Spectrometry
(UPLC‐PDA‐ESI‐MS)‐based
chemometric
analysis,
including
linear
correlation,
multiple
regression,
principal
component
analysis
(PCA).
solvent
polarity
scale
established
according
to
dielectric
constants
ɛ
).
Color
variation
(ΔE)
used
determine
presence
carotenoids,
highest
ΔE
obtained
using
low‐polarity
(hexane
ethyl
acetate).
A
high
content
capsaicin
dihydrocapsaicin
recovered
acetone
(4.29
3.76
mg
g⁻¹
dry
weight,
respectively).
Phenolic
compounds
such
as
N
‐caffeoyl
putrescine
derivatives
luteolin
apigenin
were
identified
mass
spectrometry.
(26.54–31.74
GAE
weight)
these
intermediate‐polarity
solvents.
PCA
revealed
clustering
based
affinity
for
extracting
specific
activity.
significant
correlation
observed
between
DPPH,
indicating
that
carotenoid
pigments
exhibited
higher
DPPH
radical
inhibition
capacity
than
other
compounds.
Total
(TPC)
(phenolpolyamides,
hydroxycinnamic
acids,
hydroxybenzoic
acids)
clustered
ABTS
assay.
information
is
crucial
selecting
suitable
in
extraction
purification
protocols
bioactive
It
also
valuable
conducting
plant
metabolomic
analyses
studies
focused
determining
effects
food,
pharmaceutical,
cosmeceutical
applications.
Practical
Application
results
describe
characteristics
extracts
Therefore,
may
be
useful
establishing
phytochemical
fruits
various
purposes,
activity,
food
