Can we achieve biomimetic electrospun scaffolds with gelatin alone? DOI Creative Commons
Elisa Roldán, Neil D. Reeves, Glen Cooper

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: July 12, 2023

Introduction: Gelatin is a natural polymer commonly used in biomedical applications combination with other materials due to its high biocompatibility, biodegradability, and similarity collagen, principal protein of the extracellular matrix (ECM). The aim this study was evaluate suitability gelatin as sole material manufacture tissue engineering scaffolds by electrospinning. Methods: electrospun nine different concentrations onto rotating collector resulting scaffold’s mechanical properties, morphology topography were assessed using testing, scanning electron microscopy white light interferometry, respectively. After characterizing scaffolds, effects concentration solvents crosslinking agent statistically evaluated multivariate analysis variance linear regressions. Results: Fiber diameter inter-fiber separation increased significantly when solvents, acetic acid (HAc) dimethyl sulfoxide (DMSO), increased. roughness decreased properties affected DMSO concentration. Immersed crosslinked did not degrade until day 28. manufactured gelatin-based presented comparable many human tissues such trabecular bone, gingiva, nasal periosteum, oesophagus liver tissue. Discussion: This revealed for first time that biomimetic alone can be produced significant number appropriately setting up levels factors their interactions. These findings also extend statistical relationships form would an excellent starting point future research could optimize interactions both traditional statistics machine learning techniques further develop specific

Language: Английский

Advances in wound dressing based on electrospinning nanofibers DOI Open Access
Xiaotong Zhang, Yanxin Wang, Zhiyuan Gao

et al.

Journal of Applied Polymer Science, Journal Year: 2023, Volume and Issue: 141(1)

Published: Oct. 3, 2023

Abstract In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity permeability air water, effective barrier properties against external pathogens, excellent resemblance the extracellular matrix wound healing skin regeneration. This article reviews advancements in application of electrospinning healing. The review begins with an overview process methods. It then explores advantages disadvantages different synthetic natural polymers used preparation dressings. discussed this include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, sodium alginate. Additionally, delves into commonly like polyvinyl alcohol, chloride, polyethylene lactone, polylactide, polyurethane applications. Furthermore, examines blending create high‐performance also incorporation functional additives, such as antimicrobial agents, growth factors, extracts, expedite tissue repair. conclusion, is emerging technology that provides unique opportunities designing more care products.

Language: Английский

Citations

66
Novel carboxymethyl cellulose based nanocomposite: A promising biomaterial for biomedical applications DOI
Mehrab Pourmadadi,

Erfan Rahmani,

Amin Shamsabadipour

et al.

Process Biochemistry, Journal Year: 2023, Volume and Issue: 130, P. 211 - 226

Published: April 3, 2023

Language: Английский

Citations

56
Nano and microcomposites as gamma and X-ray ionizing radiation shielding materials — A review DOI
Jolanta Sobczak, Gaweł Żyła

Energy, Journal Year: 2024, Volume and Issue: 290, P. 130210 - 130210

Published: Jan. 2, 2024

Language: Английский

Citations

25
Nanomaterials supported by polymers for tissue engineering applications: A review DOI
Faezeh Habibzadeh, Seyed Mahdi Sadraei, Roghayeh Mansoori

et al.

Heliyon, Journal Year: 2022, Volume and Issue: 8(12), P. e12193 - e12193

Published: Dec. 1, 2022

Language: Английский

Citations

51
Cellulose-Based Nanofibers Infused with Biotherapeutics for Enhanced Wound-Healing Applications DOI Creative Commons
Deepanjan Datta, Sony Priyanka Bandi,

Viola Colaco

et al.

ACS Polymers Au, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Nanofibers fabricated from various materials such as polymers, carbon, and semiconductors have been widely used for wound healing tissue engineering applications due to their excellent nontoxic, biocompatible, biodegradable properties. with a diameter in the nanometer range possess larger surface area per unit mass permitting easier addition of functionalities release biotherapeutics incorporated compared conventional polymeric microfibers. Henceforth, nanofibers are choice fabricating scaffolds management healing. Nanofibrous emerged promising method dressings since they mimic fibrous dermal extracellular matrix milieu that offers structural support functional signals guiding regeneration. Cellulose-based gained significant attention among researchers fabrication on-site fortified Cellulose is linear, stereoregular insoluble polymer built repeated units d-glucopyranose linked 1,4-β glycoside bonds complex multilevel supramolecular architecture. has by its solubility many solvents capacity self-assembly into nanofibers, facilitating mimicry natural architecture promoting substantial water retention. It also abundant demonstrates low immunogenicity humans nonanimal origins. To this end, cellulose-based studied protein delivery, antibacterial activity, biosensor applications, others. Taken together, review delves an update on fused bioactive compounds not explored considerably past few years.

Language: Английский

Citations

1
Silk biomaterials for corneal tissue engineering: From research approaches to therapeutic potentials; A review DOI
Tahereh Manoochehrabadi, Amin Solouki,

Jila Majidi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141039 - 141039

Published: Feb. 15, 2025

Language: Английский

Citations

1
Synergetic dual antibiotics-loaded chitosan/poly (vinyl alcohol) nanofibers with sustained antibacterial delivery for treatment of XDR bacteria-infected wounds DOI
Sanaz Alizadeh,

Paniz Farshi,

Navid Farahmandian

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 229, P. 22 - 34

Published: Nov. 29, 2022

Language: Английский

Citations

30
Nature-Derived Polysaccharide-Based Composite Hydrogels for Promoting Wound Healing DOI Open Access

Hyerin Lee,

Yerim Jung,

Nayeon Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16714 - 16714

Published: Nov. 24, 2023

Numerous innovative advancements in dressing technology for wound healing have emerged. Among the various types of dressings available, hydrogel dressings, structured with a three-dimensional network and composed predominantly hydrophilic components, are widely used care due to their remarkable capacity absorb abundant exudate, maintain moisture environment, provide soothing cooling effects, mimic extracellular matrix. Composite one evolved address limitations traditional by incorporating additional including particles, fibers, fabrics, or foams, within hydrogels, effectively promoting treatment healing. The added elements enhance features add specific functionalities such as sensitivity external factors, adhesiveness, mechanical strength, control over release therapeutic agents, antioxidant antimicrobial properties, tissue regeneration behavior. They can be categorized natural synthetic based on origin main components network. This review focuses recent research developing polysaccharide-based composite dressings. It explores preparation composition, reinforcement materials integrated into agents. Furthermore, it discusses wounds where applied.

Language: Английский

Citations

20
Carboxymethyl cellulose/starch-based films incorporating chitosan nanoparticles for multifunctional food packaging DOI
Yamanappagouda Amaregouda, Kantharaju Kamanna

Cellulose, Journal Year: 2024, Volume and Issue: 31(4), P. 2413 - 2427

Published: Feb. 3, 2024

Language: Английский

Citations

8
Decellularized Placental Sponge Seeded with Human Mesenchymal Stem Cells Improves Deep Skin Wound Healing in the Animal Model DOI
Sanaz Alizadeh, Leila Mahboobi,

Modara Nasiri

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2140 - 2152

Published: March 12, 2024

Skin injuries lead to a large burden of morbidity. Although numerous clinical and scientific strategies have been investigated repair injured skin, optimal regeneration therapy still poses considerable obstacle. To address this challenge, decellularized extracellular matrix-based scaffolds recellularized with stem cells offer significant advancements in skin wound healing. Herein, human placental sponge (DPS) was fabricated using the decellularization freeze-drying technique then adipose-derived mesenchymal (MSCs). The biological biomechanical properties full-thickness healing capacity cells–DPS constructs were vitro vivo. DPS exhibited uniform 3D microstructure an interconnected pore network, 89.21% porosity, low degradation rate, good mechanical properties. MSCs–DPS implanted models mice. An accelerated observed wounds construct when compared control (wounds no treatment) during 7 21 days postimplantation follow-up. In group, completely re-epithelialized, epidermis layer properly organized, dermis epidermis' bilayer structures restored after days. Our findings suggest that is excellent carrier for MSC culture delivery now promises proceed evaluations.

Language: Английский

Citations

7