Abstinence and reduced frequency of use are associated with improvements in quality of life among treatment‐seekers with cannabis use disorder

American Journal on Addictions, Journal Year: 2018, Volume and Issue: 27(2), P. 101 - 107

Published: Feb. 19, 2018

Background And Objective Many patients with cannabis use disorder (CUD) do not achieve or have abstinence as a goal of treatment, rather they reduce their use. Assessing outcome measures relate to functioning and reductions in is an important area study. Quality life (QoL) shows promise one such measure. Past studies demonstrated gender differences QoL CUD. We aim assess (1) the relationship between (2) effects outpatient medication treatment study for Methods Data from 11‐weeks, double‐blind, placebo‐controlled trial lofexidine dronabinol CUD ( n = 62) was analyzed. Pearson's correlations baseline measured Life, Enjoyment, Satisfaction Questionnaire‐Short Form (QLES‐Q‐SF) assessed modified timeline follow‐back (TLFB) were examined. Multiple linear regression models on end QLES‐Q‐SF analyzed, while adjusting QLES‐Q‐SF, arm, gender. Moderation also tested. Results No significant association found. End F 1,47 8.34, p .006) reduced proportion using days 9.48, .004) each significantly associated QoL. Reduction grams 1,27 0.25, .62) at Gender moderator. Discussion Conclusions Abstinence lower frequency are higher QoL, regardless Scientific Significance This first time has been change over course treatment. Trial Registration NCT01020019. (Am J Addict 2018;27:101–107).

Language: Английский

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Pharmacotherapies for cannabis use disorder: A systematic review and network meta-analysis

International Journal of Drug Policy, Journal Year: 2021, Volume and Issue: 97, P. 103295 - 103295

Published: July 23, 2021

Language: Английский

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Validity of the Single-Item Screen–Cannabis (SIS-C) for Cannabis Use Disorder Screening in Routine Care

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(11), P. e2239772 - e2239772

Published: Nov. 1, 2022

Importance Cannabis use is prevalent and increasing, frequent intensifies the risk of cannabis disorder (CUD). CUD underrecognized in medical settings, but a validated single-item screen could increase recognition. Objective To evaluate Single-Item Screen–Cannabis (SIS-C), administered documented routine primary care, compared with confidential reference standard measure CUD. Design, Setting, Participants This diagnostic study included sample adult patients who completed screening between January 28 September 12, 2019, were randomly selected for survey about use. Random sampling was stratified by frequency past-year race ethnicity. The conducted at an integrated health system Washington state, where legal. Data analyzed from May 2021 to March 2022. Exposures SIS-C asks responses (none, less than monthly, weekly, daily or almost daily) patients’ records. Main Outcomes Measures Diagnostic Statistical Manual , Fifth Edition ( DSM-5 ) Composite International Interview–Substance Abuse Module (CIDI-SAM) on considered standard. 2 more criteria CIDI-SAM, consistent All analyses weighted, accounting design nonresponse, obtain estimates representative care population. Results Of 5000 sampled patients, 1688 responded (34% response rate). Patients predominantly middle-aged (weighted mean [SD] age, 50.7 [18.1]), female women proportion [SE], 55.9% [4.1]), non-Hispanic 96.7% [1.0]), White 74.2% [3.7]). Approximately 6.6% met had area under receiver operating characteristic curve 0.89 (95% CI, 0.78-0.96) identifying A threshold monthly balanced sensitivity (0.88) specificity (0.83) detecting In populations 6% prevalence CUD, predictive values positive ranged 17% 34%, while negative 97% 100%. Conclusions Relevance this study, excellent performance characteristics as While high suggest that accurately identifies without low indicate need further assessment following results when care.

Language: Английский

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Cannabis and Pregnancy: A Review

Obstetrical & Gynecological Survey, Journal Year: 2023, Volume and Issue: 78(7), P. 411 - 428

Published: July 1, 2023

Importance Prenatal cannabis use is rising and a major public health issue. Cannabis in pregnancy during lactation has been associated with increased maternal offspring morbidity mortality. Objective This review aims to summarize the existing literature current recommendations for or lactation. Evidence Acquisition A PubMed, Cochrane Library, Google Scholar search using following terms was performed gather relevant data: “cannabis,” “cannabinoid,” “delta-9-tetrahydrocannabinol,” “THC,” “cannabidiol,” “fetal outcomes,” “perinatal “pregnancy,” “lactation.” Results Available studies on were reviewed support an association risk of preterm birth, neonatal intensive care unit admission, low birth weight, small-for-gestational-age infants. Conclusion Relevance There critical need research effects necessary first step before furthering patient education, developing interventions, targeting antenatal surveillance ameliorate adverse impacts fetal health. Target Audience Obstetricians gynecologists, family physicians, pediatricians Learning Objectives After participating this activity, learner should be better able describe options treatment disorder; explain common forms cannabinoids available use; discuss screening pregnancy.

Language: Английский

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Analysis of natural product regulation of opioid receptors in the treatment of human disease

Pharmacology & Therapeutics, Journal Year: 2017, Volume and Issue: 184, P. 51 - 80

Published: Oct. 31, 2017

Language: Английский

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