Biomolecules,
Journal Year:
2020,
Volume and Issue:
10(5), P. 780 - 780
Published: May 18, 2020
The
biguanide
metformin
is
the
first
drug
to
be
tested
as
a
gerotherapeutic
in
clinical
trial
TAME
(Targeting
Aging
with
Metformin).
current
consensus
that
exerts
indirect
pleiotropy
on
core
metabolic
hallmarks
of
aging,
such
insulin/insulin-like
growth
factor
1
and
AMP-activated
protein
kinase/mammalian
Target
Of
Rapamycin
signaling
pathways,
downstream
its
primary
inhibitory
effect
mitochondrial
respiratory
complex
I.
Alternatively,
but
not
mutually
exclusive,
can
exert
regulatory
effects
components
biologic
machinery
aging
itself
chromatin-modifying
enzymes.
An
integrative
metabolo-epigenetic
outlook
supports
new
model
whereby
operates
guardian
cell
identity,
capable
retarding
cellular
by
preventing
loss
information-theoretic
nature
epigenome.
ultimate
anti-aging
mechanism
might
involve
global
preservation
epigenome
architecture,
thereby
ensuring
fate
commitment
phenotypic
outcomes
despite
challenging
noise.
Metformin
therefore
inspire
development
gerotherapeutics
preserving
architecture
for
identity.
Such
should
replicate
ability
halt
erosion
epigenetic
landscape,
mitigate
commitment,
delay
stochastic/environmental
DNA
methylation
drifts,
alleviate
senescence.
Yet,
it
remains
challenge
confirm
if
changes
higher-order
genomic
organizers
connect
capacity
dynamically
regulate
three-dimensional
landscapes
4th
dimension,
time.
Foods,
Journal Year:
2022,
Volume and Issue:
11(21), P. 3377 - 3377
Published: Oct. 26, 2022
In
recent
years,
the
relationship
between
Lycium
ruthenicum
Murr.
anthocyanins
(LRA)
and
health
has
attracted
increasing
attention.
The
purpose
of
this
study
is
to
investigate
anti-aging
effect
mechanism
LRA
through
a
D-galactose
(DG)-induced
aging
rat
model.
Our
results
showed
that
long-term
intake
LRA,
for
8
weeks,
improved
motor
function,
reduced
serum
markers,
promoted
endogenous
antioxidant
system,
suppressed
inflammatory
cytokines
in
rats.
Besides,
treatment
alleviated
DG-induced
liver
injuries
by
relieving
inflammation
inhibiting
Fas/FasL-mediated
cell
death.
More
importantly,
abnormal
metabolome
profiles
rats
were
restored
relating
38
metabolites
44
pathways.
Specifically,
significantly
affected
amino
acid
protein-related
metabolic
pathways
regulating
levels
L-threonine,
L-aspartic
acid,
glycine,
L-histidine,
D-homocysteine,
L-homocitrulline,
L-homoserine,
guanidineacetic
kynurenine.
These
have
important
implications
development
as
an
liver-protective
ingredient.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2277 - 2277
Published: May 11, 2023
Metabolic
disorders
entail
both
health
risks
and
economic
burdens
to
our
society.
A
considerable
part
of
the
cause
metabolic
is
mediated
by
gut
microbiota.
The
microbial
structure
function
are
susceptible
dietary
patterns
host
physiological
activities.
sedentary
lifestyle
accompanied
unhealthy
eating
habits
propels
release
harmful
metabolites,
which
impair
intestinal
barrier,
thereby
triggering
a
constant
change
in
immune
system
biochemical
signals.
Noteworthy,
healthy
interventions,
such
as
intermittent
fasting,
coupled
with
regular
physical
exercise
can
improve
several
inflammatory
parameters,
resulting
stronger
beneficial
actions
for
health.
In
this
review,
current
progress
on
how
microbiota
may
link
mechanistic
basis
common
was
discussed.
We
also
highlight
independent
synergistic
effects
fasting
interventions
provide
perspectives
preventing
disorders.
Current Opinion in Chemical Biology,
Journal Year:
2023,
Volume and Issue:
76, P. 102360 - 102360
Published: June 30, 2023
Metabolomics,
the
global
profiling
of
small
molecules
in
body,
has
emerged
as
a
promising
analytical
approach
for
assessing
molecular
changes
associated
with
ageing
at
population
level.
Understanding
root
metabolic
pathways
may
have
important
implications
managing
age-related
disease
risk.
In
this
short
review,
relevant
studies
published
last
few
years
that
made
valuable
contributions
to
field
will
be
discussed.
These
include
large-scale
investigating
age,
metabolomic
clocks,
and
phenotypes.
Recent
significant
advances
use
longitudinal
study
designs,
populations
spanning
whole
life
course,
standardised
platforms
enhanced
metabolome
coverage
development
multivariate
analyses.
While
many
challenges
remain,
recent
demonstrated
considerable
promise
field.
Biomolecules,
Journal Year:
2020,
Volume and Issue:
10(5), P. 780 - 780
Published: May 18, 2020
The
biguanide
metformin
is
the
first
drug
to
be
tested
as
a
gerotherapeutic
in
clinical
trial
TAME
(Targeting
Aging
with
Metformin).
current
consensus
that
exerts
indirect
pleiotropy
on
core
metabolic
hallmarks
of
aging,
such
insulin/insulin-like
growth
factor
1
and
AMP-activated
protein
kinase/mammalian
Target
Of
Rapamycin
signaling
pathways,
downstream
its
primary
inhibitory
effect
mitochondrial
respiratory
complex
I.
Alternatively,
but
not
mutually
exclusive,
can
exert
regulatory
effects
components
biologic
machinery
aging
itself
chromatin-modifying
enzymes.
An
integrative
metabolo-epigenetic
outlook
supports
new
model
whereby
operates
guardian
cell
identity,
capable
retarding
cellular
by
preventing
loss
information-theoretic
nature
epigenome.
ultimate
anti-aging
mechanism
might
involve
global
preservation
epigenome
architecture,
thereby
ensuring
fate
commitment
phenotypic
outcomes
despite
challenging
noise.
Metformin
therefore
inspire
development
gerotherapeutics
preserving
architecture
for
identity.
Such
should
replicate
ability
halt
erosion
epigenetic
landscape,
mitigate
commitment,
delay
stochastic/environmental
DNA
methylation
drifts,
alleviate
senescence.
Yet,
it
remains
challenge
confirm
if
changes
higher-order
genomic
organizers
connect
capacity
dynamically
regulate
three-dimensional
landscapes
4th
dimension,
time.
