International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135052 - 135052
Published: Aug. 24, 2024
Language: Английский
Future Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 10(1)
Published: May 13, 2024
Abstract Background The study of plant-based medications, or phytomedicine, involves a wide spectrum biological activities. Due to the existence secondary metabolites, herbal medicine has been used and practiced throughout history for treatment both acute chronic conditions. Over past century so, numerous novel compounds with medicinal potential have derived from plants. In age growing super infections emergence resistant strains, natural medicines are inspiring optimism. Main body abstract review discusses role as antibacterial agents their use in wound care management wounds critical metabolites plants fighting bacterial infections. Some such St. John’s wort (SJW) ( Hypericum perforatum ), Rosemary Rosmarinus officinalis Ginger Zingiber officinale nopal cactus Opuntia ficusindica L. )) also possess range activities can give synergistic effect if combined antibiotics. addition, biopolymers play an important well physiological processes skin (hemostasis, inflammation, proliferation, remodelling). Method A narrative papers relevant phytomedicine treating was conducted by using electronic databases PubMed, CrossREF, Google Scholar. Short conclusion Phytomedicine is one top options illnesses millions people around world. To learn about bioactive components plants, medical benefits, additive effects enhance action substantial new studies still needed. Graphical
Language: Английский
Citations
7
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(7), P. 4344 - 4357
Published: June 25, 2024
Wound dressings made from natural-derived polymers are highly valued for their biocompatibility, biodegradability, and biofunctionality. However, natural polymer-based hydrogels can come with own set of limitations, such as low mechanical strength, limited cell affinity, the potential cytotoxicity cross-linkers, which delineate boundaries usage hamper practical application. To overcome limitation polymers, this study utilized a mixture oxidized alginate gelatin 5 mg/mL polycaprolactone (PCL):gelatin nanofiber fragments at ratio 7:3 (OGN-7) to develop hydrogel composite wound dressing that be injected has ability remended. The in situ formation remendable is facilitated by dual cross-linking chains PCL/gelatin nanofibers through Schiff-base mechanisms, supported physical integration nanofibers, thereby obviating need additional agents. Furthermore, OGN-7 exhibits increased stiffness (γ = 79.4-316.3%), reduced gelation time (543 ± 475 s), improved remendability hydrogel, excellent biocompatibility. Notably, achieves full fusion within 1 h incubation maintains structural integrity under external stress, effectively overcoming inherent weaknesses enhancing therapeutic efficacy was validated full-thickness
Language: Английский
Citations
7
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132071 - 132071
Published: May 4, 2024
Wound healing is a challenging clinical problem and efficient wound management essential to prevent infection. This best done by utilizing biocompatible materials in order complete the rapid manner, with functional esthetic outcomes. In this context, zein protein fulfills criteria of ideal dressing which include non-toxicity non-inflammatory stimulation. Zein gels containing rutin were prepared without any chemical refinement or addition gelling agents obtain natural formulation characterized antioxidant anti-inflammatory properties be proposed for treatment burns sores. vitro scratch assay showed that gel formulations promoted cell migration gap closure within 24 h (~90 %). addition, vivo activities rutin-loaded greater therapeutic efficacy Wistar rats, decrease area about 90 % at day 10 respect free form bioactive DuoDERM®. The evaluation various markers (TNF-α, IL-1β, IL-6, IL-10) confirmed effect formulation. results illustrate feasibility exploiting peculiar features wound-healing purposes.
Language: Английский
Citations
6
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129514 - 129514
Published: Jan. 21, 2024
Language: Английский
Citations
5
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 168, P. 112879 - 112879
Published: July 22, 2024
Language: Английский
Citations
5
Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: unknown, P. 100594 - 100594
Published: Oct. 1, 2024
Language: Английский
Citations
5
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Nov. 5, 2023
Abstract Marine resources in unique marine environments provide abundant, cost-effective natural biomaterials with distinct structures, compositions, and biological activities compared to terrestrial species. These marine-derived raw materials, including polysaccharides, protein components, fatty acids, minerals, etc., have shown great potential preparing, stabilizing, or modifying multifunctional nano-/micro-systems are widely applied drug delivery, theragnostic, tissue engineering, etc. This review provides a comprehensive summary of the most current biomaterial-based developed over past three years, primarily focusing on therapeutic delivery studies highlighting their cure variety diseases. Specifically, we first provided detailed introduction physicochemical characteristics biocomponents state. Furthermore, assembly processes, functionalities each building block, thorough evaluation pharmacokinetics pharmacodynamics advanced systems effects molecular pathophysiological processes were fully elucidated. Finally, list unresolved issues pivotal challenges applications, such as standardized distinction long-term biosafety vivo, feasibility scale-up, was presented. is expected serve roadmap for fundamental research facilitate rational design diverse emerging applications. Graphical
Language: Английский
Citations
12
Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 90, P. 105163 - 105163
Published: Nov. 14, 2023
Language: Английский
Citations
11
International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: 74(2), P. 103 - 127
Published: Feb. 26, 2024
The global demand for wound dressing material has increased, and conventional dressings are unable to meet needs due various limitations. Researchers have recently turned electrospinning, a versatile straightforward method, address these Due its intrinsic qualities, which include remarkable similarity the extracellular matrix, researchers focused their attention on electrospun nanofibrous dressings. Drug-infused nanofibers emerging as potential alternative Also, substantial surface area in relation volume, porosity, skin's sequential electrospinning process that facilitates continuous release of drugs other points consider. At same time, natural carbohydrate polymers possess distinctive characteristics, such compatibility with biological systems, biodegradability, engaging cell communication through signaling mechanisms, easy chemical modifications, wide accessibility, making them desirable tissue engineering. In been used extensively produce nonwoven materials. However, future active nanofiber can show management color map, pH monitoring, infection detection, drug capability. This review depicts current picture some important polymers, marketed products applications dressing.
Language: Английский
Citations
4
Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: 32(8), P. 3893 - 3909
Published: March 1, 2024
Language: Английский
Citations
4