Pediatric asthma control during the COVID‐19 pandemic: A systematic review and meta‐analysis

Pediatric Pulmonology, Journal Year: 2021, Volume and Issue: 57(1), P. 20 - 25

Published: Oct. 21, 2021

Abstract Background With the onset of coronavirus disease 2019 (COVID‐19) pandemic, many experts expected that asthma‐associated morbidity because severe acute respiratory syndrome 2 infection would dramatically increase. However, some studies suggested there was no apparent increasing in asthma‐related children with asthma, it is even possible may have improved outcomes. To understand relationship between COVID‐19 pandemic and asthma outcomes, we performed this article. Methods We searched PubMed, Embase, Cochrane Library to find literature from December June 2021 related children's control, among which results such as abstracts, comments, letters, reviews, case reports were excluded. The level control during synthesized discussed by outcomes exacerbation, emergency room visit, admission, childhood test (c‐ACT). Results A total 22,159 subjects included 10 studies. Random effect model used account for data. Compared same period before exacerbation reduced (odds ratio [OR] = 0.26, 95% confidence interval [CI] [0.14–0.48], Z 4.32, p < 0.0001), odds visit decreased well (OR 0.11, CI [0.04–0.26], 4.98, 0.00001). outcome admission showed significant difference 0.84, [0.32–2.20], 0.36, 0.72). c‐ACT scores not analyzed different manifestations used. Overall, pandemic. Conclusion has been significantly improved. need exact factors leading these improvements methods sustain it.

Language: Английский

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Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 13, 2024

Abstract Background Experiences during childhood and adolescence have enduring impacts on physical mental well-being, overall quality of life, socioeconomic status throughout one’s lifetime. This underscores the importance prioritizing health children adolescents to establish an impactful healthcare system that benefits both individuals society. It is crucial for providers policymakers examine relationship between COVID-19 adolescents, as this understanding will guide creation interventions policies long-term management virus. Methods In umbrella review (PROSPERO ID: CRD42023401106), systematic reviews were identified from Cochrane Database Systematic Reviews; EMBASE (OvidSP); MEDLINE (OvidSP) December 2019 February 2023. Pairwise single-arm meta-analyses extracted included reviews. The methodological appraisal was completed using AMSTAR-2 tool. Single-arm re-presented under six domains associated with condition. classified into five according evidence classification criteria. Rosenberg’s FSN calculated binary continuous measures. Results We 1551 301 pairwise 124 met our predefined criteria inclusion. focus meta-analytical predominantly outcomes COVID-19, encompassing study designs. However, rigor suboptimal. Based gathered meta-analyses, we constructed illustrative representation disease severity, clinical manifestations, laboratory radiological findings, treatments, 2020 2022. Additionally, discovered 17 instances strong or highly suggestive concerning long-COVID, pediatric comorbidity, vaccines, health, depression. Conclusions findings advocate implementation surveillance systems track consequences establishment multidisciplinary collaborative rehabilitation programs affected younger populations. future research endeavors, it important prioritize investigation non-physical bridge gap application in field.

Language: Английский

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Drug utilisation in children and adolescents before and after the start of the COVID‐19 pandemic: Interrupted time‐series analyses in three European countries

Paediatric and Perinatal Epidemiology, Journal Year: 2024, Volume and Issue: 38(6), P. 450 - 460

Published: Feb. 1, 2024

Abstract Background The COVID‐19 pandemic has affected children and adolescents in several ways, including worsened mental health, improvement of asthma, increases diabetes ketoacidosis. Less is known about how medication use been by the pandemic. Objectives To explore drug utilisation Norway, Sweden, Italy, child age. Methods We conducted a longitudinal study among all (<18 years old) Norway Sweden nationwide paediatric database covering 3% population Italy. an interrupted time‐series analysis from January 2018 to December 2021, with March 2020 as interruption point. Dispensing or prescription rates antidepressants, anxiolytics, sleep medications, attention‐deficit/hyperactivity disorder (ADHD) insulin, asthma medications were examined. Results consisted 3,455,521 (136,188 1,160,431 2,158,902 Sweden). For there only minor changes level trend some age groups after 2020. was associated immediate decrease dispensing (range change level: −19.2 −3.7 dispensings per 1000 person‐months), increasing countries afterward trend: 0.3–6.4 especially for youngest groups. Among adolescents, increased ADHD anxiolytics but not Conclusions psychotropic dispensing, start pandemic, concerning should be investigated further. Aside temporary effect on did greatly affect investigated.

Language: Английский

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Challenges in uncontrolled asthma in pediatrics: important considerations for the clinician

Expert Review of Clinical Immunology, Journal Year: 2022, Volume and Issue: 18(8), P. 807 - 821

Published: June 22, 2022

Despite symptoms control being the primary focus of asthma management according to guidelines, uncontrolled is still an issue worldwide, leading huge costs and deaths at all ages. In childhood, poor can be even more harmful, as it irreversibly compromise children's lung function whole family's well-being.Given problem extent, this review aims discuss modifiable causes in Pediatrics, giving some practical insights regarding critical role families main tools for monitoring drug adherence, a distance. The most recent GINA documents were used reference, along with latest evidence impact COVID-19 pandemic on asthma.In managing pediatric asthma, multidisciplinary, multi-determinant, personalized approach needed, actively involving families, schools, other specialists. addition current strategies implementing control, electronic health strategies, new validated tools, identification novel inflammatory biomarkers could lead increasingly tailored therapies greater effectiveness reaching control.

Language: Английский

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The impact of COVID‐19 lockdown measures on symptoms control in children with asthma: A systematic review and meta‐analysis of observational cohort studies

Pediatric Pulmonology, Journal Year: 2023, Volume and Issue: 58(11), P. 3213 - 3226

Published: Aug. 22, 2023

Abstract Objectives Reported reductions in emergency department visits and hospitalizations for asthma previous studies have suggested a beneficial effect of the coronavirus disease 2019 (COVID‐19) lockdown measures on morbidity. Nevertheless, relying administrative data may overestimate true impact lockdowns due to changes health‐seeking behavior reduced availability pediatric services during pandemic. In this study, we systematically reviewed literature identified observational cohort that focused nonadministrative assess COVID‐19 symptom control children with asthma. Methods A systematic search was conducted between January 2020 August 2022 (International Prospective Register Systematic Reviews ID: CRD42022354369). The across expressed as standardized mean difference (SMD) continuous outcomes summary relative risk (RR) binary outcomes. Results During periods, pooled symptoms test score (SMD: 1.99, 95% confidence interval [CI]: 0.75, 3.24, I 2 : 98.4%) proportion well‐controlled (RR: 1.35, CI: 1.06, 1.71, 77.6%) were significantly increased. On other hand, poorly controlled 0.47, 0.38, 0.57, 0.0%) decreased. Conclusions lockdowns, breakthrough exacerbations Further research is warranted potential interventions aiming enhance after pandemic while taking into consideration their acceptability tradeoffs.

Language: Английский

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COVID-19 in Pediatric Populations

Clinics in Chest Medicine, Journal Year: 2024, Volume and Issue: 45(3), P. 675 - 684

Published: July 26, 2024

Language: Английский

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COVID‐19 in Children With Severe Lung Disease—A Tertiary Center Cohort Study in Denmark

Pediatric Pulmonology, Journal Year: 2025, Volume and Issue: 60(4)

Published: April 1, 2025

ABSTRACT Background Severe lung disease such as chronic pulmonary (CPD), severe asthma and cystic fibrosis (CF) in children is associated with increased risk of COVID‐19. Information regarding SARS‐CoV‐2 infection, severity outcome COVID‐19 limited this pediatric population. Objectives We captured the number infected evaluated non‐immunized CPD, asthma, CF a cohort at Danish tertiary center. Methods The PCR‐verified infection age‐related background population was identified through Microbiology Database. Clinical data were retrieved from electronic medical health records Health Authority. Results In 664 594 either PCR‐tested or had an antibody test for due to symptoms exposure 18 (3%) verified infection. total that time 34.575(4.342%) thus, not significantly different reference ( p = 0.152). ranged asymptomatic mild symptoms, none required hospitalization None treated antiviral treatment during acute Conclusion Of disease, hospitalized Our findings imply particular group patients do experience

Language: Английский

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Allergic diseases and immunodeficiencies in children, lessons learnt from COVID‐19 pandemic by 2022: A statement from the EAACI‐section on pediatrics

Pediatric Allergy and Immunology, Journal Year: 2022, Volume and Issue: 33(10)

Published: Sept. 30, 2022

Abstract By the April 12, 2022, COVID‐19 pandemic had resulted in over half a billion people being infected worldwide. There have been 6.1 million deaths directly due to infection, but has many more short‐ and long‐term pervasive effects on physical mental health of population. Allergic diseases are among most prevalent noncommunicable chronic pediatric population, health‐care professionals researchers were seeking answers since beginning pandemic. Children at lower risk developing severe or dying from infection. not associated with higher severity mortality, apart severe/poorly controlled asthma. The disrupted routine care, mitigation strategies, including limited telemedicine, successfully implemented continue delivery high‐standard care. Although children faced multitude pandemic‐related issues, allergic conditions effectively treated remotely while reduction air pollution lack contact outdoor allergens improvement, particularly respiratory allergies. is no evidence recommend substantial changes usual management modalities children, allergen immunotherapy use biologicals. greater multisystem inflammatory syndrome development, some associations Long COVID reported, although data limited, further research needed. This statement EAACI Section Pediatrics provides recommendations based lessons learnt pandemic, as available evidence.

Language: Английский

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Childhood asthma diagnoses declined during the COVID-19 pandemic in the United States

Respiratory Research, Journal Year: 2023, Volume and Issue: 24(1)

Published: March 10, 2023

Abstract Background Prior studies have documented declines in pediatric asthma exacerbations and asthma-related health care utilization during the COVID-19 pandemic, but less is known about incidence of pandemic. Methods We conducted a retrospective cohort study children under age 18 without prior diagnosis within large US commercial claims database. Incident was defined using combination codes, location services, medication dispensing. Crude quarterly rates per 1000 were calculated, rate ratio 95% confidence interval estimated for newly diagnosed versus before pandemic negative binomial regression, adjusted age, sex, region, season. Results Compared with 3 years to crude incident decreased by 52% across first four quarters The covariate-adjusted pandemic-associated 0.47 (95% 0.43, 0.51). Conclusions New diagnoses childhood declined half year These findings raise important questions whether pandemic-related changes infectious or other triggers truly altered beyond well-described disruptions healthcare access.

Language: Английский

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Healthcare utilization in Canadian children and young adults with asthma during the COVID-19 pandemic

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(1), P. e0280362 - e0280362

Published: Jan. 13, 2023

Literature is limited regarding the COVID-19 pandemic’s impact on health services use in younger Canadian populations with asthma. We utilized administrative databases from January 2019–December 2021 for a population-based cross-sectional study to identify Ontario residents 0–25 years old physician-diagnosed asthma and calculate rates of healthcare use. Multivariable negative binomial regression analysis was used adjust confounders. included 716,690 children young adults ≤25 years. There sharp increase ICS SABA prescription at start pandemic (March 2020) 61.7% 54.6%, respectively. Monthly virtual physician visit increased zero 0.23 per 100 population during pandemic. After adjusting potential confounders, rate ratios (RR) 95% confidence intervals (CI) showed that associated significant decrease hospital admissions (RR = 0.21, CI: 0.18–0.24), emergency department visits 0.35, 0.34–0.37), 0.61, 0.60–0.61). prescriptions filled also significantly decreased 0.58, 0.57–0.60 RR 0.47, 0.46–0.48, respectively). This demonstrated dramatic decline visits, hospitalizations, medication An extensive evaluation factors contributing an 80% reduction risk hospitalization may inform post-pandemic management.

Language: Английский

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