Inorganica Chimica Acta,
Journal Year:
2017,
Volume and Issue:
481, P. 25 - 31
Published: April 22, 2017
The
structural
difference
between
tyrosinase
and
catechol
oxidase
as
the
basis
for
their
catalytic
activity
is
still
a
puzzle
although
several
crystal
structures
of
both
enzymes
exist.
In
this
review
we
discuss
motifs
that
had
been
proposed
to
be
responsible
lack
hydroxylase
activity.
However,
up
now,
all
worked
out
restrictions
could
disproved
by
more
recent
type-III-copper
enzymes.
search
function-determining
amino
acids
continues
after
decades
intensive
research
do
not
know
than
substrate
binding
residues
must
directly
mono-
and/or
diphenolase
last
part
discusses
possibilities
address
topic
in
future:
What
causes
different
functionality
enzymes?
Fish & Shellfish Immunology,
Journal Year:
2024,
Volume and Issue:
148, P. 109523 - 109523
Published: March 24, 2024
Melanin
and
the
process
of
melanin
synthesis
or
melanogenesis
have
central
roles
in
immune
system
insects,
production
melanin-synthesizing
enzymes
from
their
haemocytes
may
be
induced
following
activation
through
danger
signals.
Melanin-containing
macrophage-like
cells
been
extensively
studied
amphibians
they
are
also
present
reptiles.
In
fish,
melano-macrophages
especially
recognized
with
respect
to
melano-macrophage
centres
(MMCs),
hypothesized
analogues
germinal
secondary
lymphoid
organs
mammals
some
birds.
Melano-macrophages
addition
several
inflammatory
conditions,
particular
melanised
focal
changes,
black
spots,
musculature
farmed
Atlantic
salmon,
Salmo
salar.
Melanins
complex
compounds
that
divided
into
different
forms
which
all
ability
absorb
scatter
light.
Other
functions
include
quenching
free
radicals
a
direct
effect
on
system.
According
common
view
held
pigment
cell
community,
vertebrate
melanosome
formation
only
occur
ectodermal
origin.
However,
abundant
information
suggests
myeloid
ectothermic
vertebrates
classified
as
melanocytes.
Here,
we
discuss
these
opposing
views
review
relevant
literature.
Finally,
current
status
research
concerning
muscle
changes
represent
most
severe
quality
problem
Norwegian
salmon
production,
but
other
diseases
where
play
important
roles.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 289 - 289
Published: Jan. 13, 2025
Fifteen
compounds
(1–15)
constructed
on
a
hybrid
structure
combining
β-phenyl-α,β-unsaturated
carbonyl
template
and
2-aminothiazol-4(5H)-one
scaffold
were
designed
synthesized
as
potential
novel
anti-tyrosinase
substances.
Two
(10
15)
showed
more
potent
inhibition
against
mushroom
tyrosinase
than
kojic
acid,
the
inhibitory
activity
of
10
(IC50
value:
1.60
μM)
was
11
times
stronger
that
acid.
Lineweaver–Burk
plots
indicated
these
two
competitive
inhibitors
bound
to
active
site,
which
supported
by
in
silico
experiments.
Compound
an
anti-melanogenic
substance
B16F10
cells
without
cytotoxicity.
15
exhibited
most
effect
zebrafish
larval
depigmentation
comparable
even
at
concentration
200
lower.
Compounds
8
strong
antioxidant
capacities,
scavenging
2,2-diphenyl-1-picrylhydrazyl,
(2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic
acid)+
radicals,
reactive
oxygen
species.
Hybrid
are
therapeutic
agents
for
skin
hyperpigmentation
disorders.
Applied and Environmental Microbiology,
Journal Year:
2019,
Volume and Issue:
86(5)
Published: Dec. 16, 2019
Melanins
are
macromolecules
that
ubiquitous
in
nature
and
impart
a
large
variety
of
biological
functions,
including
structure,
coloration,
radiation
resistance,
free
radical
scavenging,
thermoregulation.
Currently,
the
majority
investigations,
melanins
either
chemically
synthesized
or
extracted
from
animals,
which
presents
significant
challenges
for
large-scale
production.
Bacteria
have
been
used
as
biocatalysts
to
synthesize
biomaterials
due
their
fast
growth
amenability
genetic
engineering
using
synthetic
biology
tools.
In
this
study,
we
engineered
extremely
fast-growing
bacterium
V.
natriegens
melanin
nanoparticles
by
expressing
heterologous
tyrosinase
gene
with
inducible
promoters.
Characterization
produced
-produced
revealed
it
exhibited
physical
chemical
properties
similar
those
natural
melanins,
nanoparticle
protection
against
UV
damage,
adsorption
toxic
compounds.
We
anticipate
producing
controlling
structures
at
nanoscale
bacterial
system
tools
will
enable
design
rapid
production
novel
multiple
applications.
Inorganica Chimica Acta,
Journal Year:
2017,
Volume and Issue:
481, P. 25 - 31
Published: April 22, 2017
The
structural
difference
between
tyrosinase
and
catechol
oxidase
as
the
basis
for
their
catalytic
activity
is
still
a
puzzle
although
several
crystal
structures
of
both
enzymes
exist.
In
this
review
we
discuss
motifs
that
had
been
proposed
to
be
responsible
lack
hydroxylase
activity.
However,
up
now,
all
worked
out
restrictions
could
disproved
by
more
recent
type-III-copper
enzymes.
search
function-determining
amino
acids
continues
after
decades
intensive
research
do
not
know
than
substrate
binding
residues
must
directly
mono-
and/or
diphenolase
last
part
discusses
possibilities
address
topic
in
future:
What
causes
different
functionality
enzymes?
