Effect of nanoformulation Azadirachta indica on some factors associated with the vectorial capacity and competence of Anopheles aquasalis experimentally infected with Plasmodium vivax. DOI Creative Commons

Paula Andrea Urrea Aguirre,

Keillen Monick Martins,

Campos Duván Dueñas López

et al.

Acta Tropica, Journal Year: 2024, Volume and Issue: 255, P. 107223 - 107223

Published: April 19, 2024

Malaria remains a highly prevalent infectious disease worldwide, particularly in tropical and subtropical regions. Effectively controlling of mosquitoes transmitting Plasmodium spp. is crucial to control this disease. A promising strategy involves utilizing plant-derived products, such as the Neem tree (Azadirachta indica), known for its secondary metabolites with biological activity against various insect groups agricultural public health importance. This study investigated effects nanoformulation prototype on factors linked vector competence Anopheles aquasalis, malaria Latin America. Different concentrations were supplied through sugar solution blood feeding, assessing impacts longevity, fecundity, fertility, transgenerational survival from larvae adults. Additionally, NeemAZAL® formulation sporogonic cycle P. vivax evaluated. Overall, significant observed at 100 ppm 1,000 adult patterns F1 generation. trend reduced oviposition hatching rates was also noted nanoformulation-consuming groups, fertility fecundity declining proportionally concentration. decrease infection rate intensity group, mean 3 oocysts per female compared control's 27 female. In commercial formulation, highest tested concentration yielded 5.36 Concerning sporozoite numbers, there reduction 52 % 87 group. conclusion, these findings suggest that A. indica potential tool longevity reproductive capacity, possibly leading decreased population densities. Moreover, interfered development vivax. However, further basic research formulations, their effects, mechanisms action imperative gain more specific perspective safe field implementation.

Language: Английский

Azadirachtin-Based Insecticide: Overview, Risk Assessments, and Future Directions DOI Creative Commons
Samira Kilani‐Morakchi, Houda Morakchi-Goudjil, Karima Sifi

et al.

Frontiers in Agronomy, Journal Year: 2021, Volume and Issue: 3

Published: July 20, 2021

In the context of major crop losses, pesticides will continue to play a key role in pest management practice absence practical and efficient alternatives; however, increasing awareness regarding environmental human health impacts conventional as well development resistance cross-resistance reduced their availability promoted search for alternative control strategies reduced-risk pesticides. Among various alternatives, drastic re-emergence interest use plant-derived compounds, called allelochemicals, was noted demand an organic product is rising. Currently, azadirachtin, tetranortriterpenoid derived from neem seed Indian tree [ Azadirachta indica A. Juss (Meliaceae)], one prominent biopesticides commercialized remains most successful botanical pesticide agricultural worldwide. Azadirachtin powerful antifeedant insect growth disruptor with exceptional low residual power toxicity biocontrol agents, predators, parasitoids. This review summarizes state art on azadirachtin insecticidal activities risk assessment, identifies knowledge gaps that could serve basis future research direction highlights limitation novel by nanotechnology its release rate improve stability sustainability.

Language: Английский

Citations

113
Chemistry, bioactivities, extraction and analysis of azadirachtin: State-of-the-art DOI
Sara R. Fernandes, Luísa Barreiros, Rita Oliveira

et al.

Fitoterapia, Journal Year: 2019, Volume and Issue: 134, P. 141 - 150

Published: Feb. 10, 2019

Language: Английский

Citations

86
Identification of azadirachtin responsive genes in Spodoptera frugiperda larvae based on RNA-seq DOI Creative Commons
Benshui Shu,

Haikuo Yu,

Li Yuning

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2020, Volume and Issue: 172, P. 104745 - 104745

Published: Nov. 7, 2020

Language: Английский

Citations

41
Insecticidal Triterpenes in Meliaceae: Plant Species, Molecules and Activities: Part Ⅰ (Aphanamixis-Chukrasia) DOI Open Access

Meihong Lin,

Sifan Yang, Jiguang Huang

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(24), P. 13262 - 13262

Published: Dec. 9, 2021

Plant-originated triterpenes are important insecticidal molecules. The research on activity of molecules from Meliaceae plants has always received attention due to the this family showing a variety activities with diverse mechanisms action. In paper, we discuss 102 triterpenoid eight genera (Aglaia, Aphanamixis, Azadirachta, Cabralea, Carapa, Cedrela, Chisocheton, and Chukrasia) in Meliaceae. total, 19 plant species presented. Among these species, Azadirachta indica A. Juss is most well-known azadirachtin active molecule widely recognized highly effective botanical insecticide. However, it noteworthy that six Cedrela were reported show deserve future study. total summarized, including 96 nortriterpenes, 4 tetracyclic triterpenes, 2 pentacyclic triterpenes. Results showed antifeedant activity, growth inhibition poisonous or other activities. them, 43 15 against 16 insect 49 14 exhibited 10 11 possessed regulatory 12 species. molecules, azadirachtins found be successful insecticides. Still, more than one type obvious 7-deacetylgedunin, salannin, gedunin, azadirone, salannol, azadiradione, methyl angolensate. Most only primary stage study activity; their mechanism action structure-activity relationship warrant further

Language: Английский

Citations

36
A review of physiological resistance to insecticide stress in Nilaparvata lugens DOI
Bin Tang, Kang Xu, Yongkang Liu

et al.

3 Biotech, Journal Year: 2022, Volume and Issue: 12(3)

Published: Feb. 28, 2022

Language: Английский

Citations

25
Azadirachtin-Mediated Responses in the Maize Weevil, Sitophilus zeamais (Coleoptera: Curculionidae) DOI Creative Commons

Herlinda Quintero,

Johana Elizabeth Quintero Cortes, Angelica Plata‐Rueda

et al.

Insects, Journal Year: 2025, Volume and Issue: 16(3), P. 294 - 294

Published: March 12, 2025

Corn is one of the world’s most economically important cereal crops and can be attacked by Sitophilus zeamais. The control S. zeamais mostly based on synthetic insecticides; however, populations this insect have developed resistance to various chemical compounds. New rational insecticides that prevent development resistant need continuously evaluated. This research aimed assess effects mediated azadirachtin in terms mortality, survival, food preference, repellency. Azadirachtin toxic at larval (LC50 = 3.36 ppm), pupal 23.0 adult 37.7 ppm) stages. At all stages development, survival rate was 99.9% insects not treated with azadirachtin, decreasing 29.9%, 44.9%, 68.5% larvae, pupae, adults LC50 bioinsecticide, respectively. preference for untreated corn grains higher LC25 while LC95 (209 repelled adults. causes lethality zeamais, compromising its reducing feeding protected repellent activity high concentrations. Therefore, use bioinsecticide may offer an alternative field post-harvest.

Language: Английский

Citations

0
Azadirachtin acting as a hazardous compound to induce multiple detrimental effects in Drosophila melanogaster DOI
Jing Zhang, Tao Sun, Zhipeng Sun

et al.

Journal of Hazardous Materials, Journal Year: 2018, Volume and Issue: 359, P. 338 - 347

Published: July 23, 2018

Language: Английский

Citations

34
Azadirachtin Inhibits Nuclear Receptor HR3 in the Prothoracic Gland to Block Larval Ecdysis in the Fall Armyworm, Spodoptera frugiperda DOI
Shuting Fan,

Mian‐Zhi Wu,

Chang Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(42), P. 15497 - 15505

Published: Oct. 16, 2023

Azadirachtin has been used to control agricultural pests for a long time; however, the molecular mechanism of azadirachtin on lepidopterans is still not clear. In this study, fourth instar larvae fall armyworm were fed with azadirachtin, and then ecdysis was blocked in larval stage (L4). The prothoracic glands (PGs) treated dissected RNA sequencing determine effect inhibition. Interestingly, one PG-enriched genes, nuclear hormone receptor 3 (HR3), decreased after treatment, which plays critical role 20-hydroxyecdysone action during ecdysis. To deepen understanding ecdysis, HR3 knocked out by using CRISPR/Cas9 system, while mutants displayed embryonic lethal phenotype; thus, stage-specific function molting enabled unfold. Hence, siRNA injected into 24 h L4 knock down HR3. After 96 h, old cuticle consistent azadirachtin-treated larvae. Taken together, we envisioned that inhibition treatment due an interference expression PG, resulting mortality. results study specified insect lepidopteran vivo.

Language: Английский

Citations

10
Azadirachtin-Based Biopesticide Affects Fitness and Ovarian Development of the Natural Enemy Ceraeochrysa claveri (Neuroptera: Chrysopidae) DOI Creative Commons
Bertha Gastelbondo, Marilucia Santorum, Elton Luiz Scudeler

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(3), P. 416 - 416

Published: Jan. 31, 2025

Plant-derived biopesticides have gained attention in agriculture as a pest control method that minimizes the negative effects caused by conventional synthetic insecticides to natural enemies. Azamax™ is one of most commercialized Brazil, but little known about its on non-target insects such Ceraeochrysa claveri, insect economically important predator, used this study. To evaluate toxic azadirachtin fitness and ovarian development, total 450 C. claveri larvae were exposed ingestion subdoses (36 mg/L (0.3%) 60 (0.5%) for 15 days after that, biological parameters development analyzed. The doses tested corresponded minimum maximum concentrations field. results demonstrated both biopesticide significantly reduced survival rates, delayed extended larval pupal times, malformations body, altered ultrastructure adult ovaries, induced cell death follicles. Azamax™, marketed reduced-risk insecticide, was shown detrimental lifespan claveri.

Language: Английский

Citations

0
Azadirachtin A and B: A New Biological Tool to a Sustainable Management of Diatraea saccharalis (Lepidoptera: Crambidae) DOI Creative Commons
Silvio Lisboa de Souza, Anderson Antero Dutra da Silva, Evelyn Sales Victor

et al.

Brazilian Archives of Biology and Technology, Journal Year: 2025, Volume and Issue: 68

Published: Jan. 1, 2025

Abstract Biopesticides have shown high potential in controlling insect pests, including Diatraea saccharalis Fabr. (Lepidoptera: Crambidae). From that perspective, this study evaluated lethal concentrations of the product Fitoneem®, which has Azadirachtin A and B, its impact on mortality pattern D. saccharalis. Fitoneem® was diluted distilled water at 5000 ppm, 10000 20000 30000 50000 ppm. The larvae were exposed to through following exposure routes: (1) topical spray, applying directly larvae's prothorax; (2) ingestion, exposing inoculation artificial diet; (3) spraying entire body insect, using a manual spray bottle. After exposure, assessed 24 intervals for six consecutive days. According studied via all over showed LC50 18500 ppm LC90 55100 ppm; application, 15700 17400 22500 70400 median time ranged from 96 144 hours. Therefore, low promotes levels Hence, our results show B manage crucial pest sugarcane information can contribute understanding action mode insect.

Language: Английский

Citations

0