Chitosan-based mucoadhesive films loaded with curcumin for topical treatment of oral cancer

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134887 - 134887

Published: Aug. 19, 2024

Language: Английский

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MACC1-Dependent Antitumor Effect of Curcumin in Colorectal Cancer

Nutrients, Journal Year: 2022, Volume and Issue: 14(22), P. 4792 - 4792

Published: Nov. 12, 2022

Metastasis is the main reason for high mortality rate of colorectal cancer (CRC) patients. Despite whole improvement in field medicine, treatment options patient late stages are very restricted. Our previous studies have elucidated metastasis-associated colon 1 (MACC1) as a direct link to metastasis formation. Therefore, we aimed inhibit its expression by using natural products, which recently center most due their low side effects and good tolerability. In this study, investigated effect one promising curcumin, on MACC1 MACC1-induced tumor-promoting pathways. Curcumin reduced expression, restricted proliferation, was able reduce cell motility crucial steps distant dissemination tumor. We further showed MACC1-dependent curcumin clonogenicity wound healing. This study is, our knowledge, first identification restriction motility, colony-forming ability target.

Language: Английский

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Curcumin in Cancer Therapy: Mechanisms, Delivery Systems, and Clinical Potential

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Curcumin, a polyphenolic compound derived from the turmeric plant (Curcuma longa), has garnered significant attention for its potential anticancer properties due to ability modulate multiple molecular targets involved in cancer development and progression. This chapter provides comprehensive overview of curcumin’s mechanisms action therapy, focusing on effects cell proliferation, apoptosis, metastasis, inflammation. Curcumin exerts through various signaling pathways, including suppression NF-κB, JAK/STAT3, PI3K/Akt, modulation cycle regulators. Despite promising potential, curcumin faces challenges clinical applications poor bioavailability, low solubility, rapid metabolism. To overcome these limitations, innovative drug delivery systems, such as nanoparticles, liposomes, polymer-based formulations, have been developed enhance therapeutic efficacy stability. These systems improve targeted delivery, controlled release curcumin, thereby maximizing while minimizing systemic toxicity. Moreover, preclinical studies assessing combination with other chemotherapeutic agents role an adjuvant treatment shown results. The concludes by discussing future directions curcumin-based therapies, need further trials establish optimal dosage, formulation, regimens be integrated into personalized treatments.

Language: Английский

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Anti-breast Cancer Activity of pH-responsive Nanogel Loaded with Curcumin

Journal of Wuhan University of Technology-Mater Sci Ed, Journal Year: 2025, Volume and Issue: 40(3), P. 895 - 903

Published: May 17, 2025

Language: Английский

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Therapeutic potential of p53 reactivation in cervical cancer

Critical Reviews in Oncology/Hematology, Journal Year: 2020, Volume and Issue: 157, P. 103182 - 103182

Published: Nov. 24, 2020

Language: Английский

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