Assessment of the Anti-Amyloidogenic Properties of Essential Oils and Their Constituents in Cells Using a Whole-Cell Recombinant Biosensor DOI Creative Commons

Electra Stylianopoulou,

Anastasia Daviti,

Venetia Giourou

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 14(1), P. 35 - 35

Published: Dec. 29, 2023

Essential oils exhibit numerous medicinal properties, including antimicrobial, anti-inflammatory and antioxidant effects. Recent studies also indicate that certain essential demonstrate anti-amyloidogenic activity against β-amyloid, the protein implicated in Alzheimer’s disease. To investigate whether anti-aggregating properties of extend to α-synuclein, involved Parkinson’s disease, we constructed employed a whole-cell biosensor based on split-luciferase complementation assay. We validated our by using baicalein, known inhibitor α-synuclein aggregation, subsequently tested eight commonly used food hygienic industry. Two them, citron sage, along with their primary components, pure linalool (the main constituent oil) eucalyptol (1,8-cineole, sage oil), were able reduce α-syn aggregation. These findings suggest both constituents could be regarded as potential components functional foods or incorporated into complementary disease therapies.

Language: Английский

Plant Natural Products With Anti-Aging, Antioxidative, and Neuroprotective Properties DOI
Michaël Wink

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 66

Published: April 25, 2025

Reactive oxygen species (ROS) can cause oxidative stress which plays a prominent role in the pathophysiology of several health conditions, such as cardiovascular disorders, neurodegenerative diseases, importantly cancer prevention and aging/longevity. Many medicinal food plants, spices beverages contain phenolics, polyphenols, carotenoids, isothiocyanates, allicin, even chlorophyll other secondary metabolites (PSM) with substantial antioxidant properties. Therefore, supplementation our diet plant-derived antioxidants is regarded potential strategy to delay or prevent onset age-related diseases promote longevity. In order understand underlaying biochemical pharmacological mechanisms, scientists have employed nematode Caenorhabditis elegans model, easily be maintained laboratory. C. has been used for over last 25 years explore anti-aging properties isolated PSM complex plant extracts. this chapter, recent studies on antioxidant, longevity-promoting neuroprotective activities extracts were reviewed.

Language: Английский

Citations

0
Linalool and Geraniol Defend Neurons from Oxidative Stress, Inflammation, and Iron Accumulation in In Vitro Parkinson’s Models DOI Creative Commons
Edina Pandur, Balázs Major, Tibor Rák

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 917 - 917

Published: July 29, 2024

Parkinson's disease is one of the most prevalent neurological disorders affecting millions people worldwide. There a growing demand for novel and natural substances as complementary therapies. Essential oils their various compounds are highly investigated plant-based products potential treatment options common human diseases, such microbial infections, chronic neurodegenerative disorders. The present study focuses on beneficial effects linalool geraniol, major lavender (

Language: Английский

Citations

3
Essential Oil Molecules Can Break the Loop of Oxidative Stress in Neurodegenerative Diseases DOI Creative Commons
Enzo Spisni, Maria Chiara Valerii, Maria Lina Massimino

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(12), P. 1504 - 1504

Published: Dec. 7, 2023

Essential oils (EOs) are mixtures of volatile compounds, extracted from aromatic plants, with multiple activities including antioxidant and anti-inflammatory ones. EOs complex easy to find on the market low costs. In this mini narrative review, we have collected results in vitro vivo studies, which tested these validated models neurodegeneration particular two main neurodegenerative diseases (NDs) that afflict humans: Alzheimer's Parkinson's. Since EO compositions can vary greatly, depending environmental conditions, plant cultivar, extraction methods, focused our attention studies involving single molecules, those demonstrated ability cross blood-brain barrier. These alone or defined mixtures, could be interesting new therapies prevent slow down oxidative inflammatory processes common mechanisms contribute neuronal death all NDs.

Language: Английский

Citations

6
The antioxidant efficacy of Syagrus coronata fixed oil in reverting rotenone-induced neurotoxicity in mice DOI
Luciclaudio Cassimiro de Amorim, Iverson Conrado Bezerra, Artur José da Silva

et al.

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: 3, P. 100045 - 100045

Published: April 16, 2024

Language: Английский

Citations

2
Advanced matter-element extension model and machine learning for source-specific probabilistic health risk assessment of heavy metals/metaloids in soil-rose systems in Kushui, Northwest China DOI Creative Commons
Jun Li, Liyang Ma, Junzhuo Liu

et al.

Ecological Indicators, Journal Year: 2024, Volume and Issue: 170, P. 113017 - 113017

Published: Dec. 28, 2024

Language: Английский

Citations

1
Study on the Factors Affecting the Extraction Rate of Volatile Oil in Rose DOI

托合提如孜 热罕古丽·

Journal of Organic Chemistry Research, Journal Year: 2023, Volume and Issue: 11(04), P. 165 - 170

Published: Jan. 1, 2023

Language: Английский

Citations

2
Assessment of the Anti-Amyloidogenic Properties of Essential Oils and Their Constituents in Cells Using a Whole-Cell Recombinant Biosensor DOI Creative Commons

Electra Stylianopoulou,

Anastasia Daviti,

Venetia Giourou

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 14(1), P. 35 - 35

Published: Dec. 29, 2023

Essential oils exhibit numerous medicinal properties, including antimicrobial, anti-inflammatory and antioxidant effects. Recent studies also indicate that certain essential demonstrate anti-amyloidogenic activity against β-amyloid, the protein implicated in Alzheimer’s disease. To investigate whether anti-aggregating properties of extend to α-synuclein, involved Parkinson’s disease, we constructed employed a whole-cell biosensor based on split-luciferase complementation assay. We validated our by using baicalein, known inhibitor α-synuclein aggregation, subsequently tested eight commonly used food hygienic industry. Two them, citron sage, along with their primary components, pure linalool (the main constituent oil) eucalyptol (1,8-cineole, sage oil), were able reduce α-syn aggregation. These findings suggest both constituents could be regarded as potential components functional foods or incorporated into complementary disease therapies.

Language: Английский

Citations

0