Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
72(1), P. 4 - 26
Published: Dec. 29, 2023
Food
safety
has
become
an
attractive
topic
among
consumers.
Raw
material
production
for
food
is
also
a
focus
of
social
attention.
As
hormones
are
widely
used
in
agriculture
and
human
disease
control,
consumers'
concerns
about
the
hormone
agents
have
never
disappeared.
The
present
review
focuses
on
interkingdom
regulations
exogenous
animal
plants
phytohormones
animals,
including
physiology
stress
resistance.
We
summarize
these
interactions
to
give
public,
researchers,
policymakers
some
guidance
suggestions.
Accumulated
evidence
demonstrates
comprehensive
hormonal
regulation
across
animals.
Animal
hormones,
interacting
with
phytohormones,
help
regulate
plant
development
enhance
environmental
Correspondingly,
may
cause
damage
reproductive
urinary
systems
Notably,
disease-resistant
role
revealed
against
neurodegenerative
diseases,
cardiovascular
disease,
cancer,
diabetes.
These
resistances
derive
from
control
abnormal
cell
cycle,
energy
balance,
activity
enzymes.
Further
exploration
cross-kingdom
mechanisms
would
surely
be
greater
benefit
health
development.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(1), P. 154 - 154
Published: Jan. 2, 2024
Endometriosis
is
a
chronic,
hormone-dependent
disease
characterized
by
the
presence
of
endometrial
tissue
in
ectopic
locations.
Since
treatment
options
for
this
are
still
limited,
and
cure
rate
unsatisfactory,
search
ways
to
treat
symptoms
modify
course
key
importance
improving
quality
life
patients
with
endometriosis.
So
far,
literature
has
shown
that
nutrition
can
influence
endometriosis
through
hormonal
modification
altering
inflammatory
or
oxidative
response.
subject
scientific
research,
we
aimed
summarize
current
knowledge
on
role
dietary
modifications
Our
review
showed
nutrients
anti-inflammatory
antioxidant
properties,
including
most
vitamins
several
trace
elements,
may
pathogenesis
be
considered
as
preventing
development
However,
despite
many
discoveries
described
review,
further
interdisciplinary
research
topic
seems
extremely
important,
future,
it
result
personalized
therapies
supporting
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(6), P. 3060 - 3079
Published: April 11, 2024
Abstract
Phytoestrogens,
also
known
as
xenoestrogens,
are
secondary
metabolites
derived
from
plants
that
have
similar
structures
and
biological
effects
human
estrogens.
These
compounds
do
not
directly
affect
functions
but
can
act
agonists
or
antagonists
depending
on
the
level
of
endogenous
estrogen
in
body.
Phytoestrogens
may
an
epigenetic
mechanism
action
independent
receptors.
found
more
than
300
plant
species
synthesized
through
phenylpropanoid
pathway,
with
specific
enzymes
leading
to
various
chemical
structures.
primarily
phenolic
compounds,
include
isoflavonoids,
flavonoids,
stilbenes,
lignans.
Extensive
research
animals
humans
has
demonstrated
protective
phytoestrogens
estrogen‐dependent
diseases.
Clinical
trials
shown
their
potential
benefits
conditions
such
osteoporosis,
Parkinson's
disease,
certain
types
cancer.
This
review
provides
a
concise
overview
phytoestrogen
classification,
diversity,
biosynthesis
discusses
therapeutic
phytoestrogens,
well
preclinical
clinical
development.
International Journal of Women s Health,
Journal Year:
2024,
Volume and Issue:
Volume 16, P. 693 - 705
Published: April 1, 2024
Postmenopausal
osteoporosis
stands
as
the
predominant
bone
disorder
in
developed
world,
posing
a
significant
public
health
challenge.
Nutritional
factors
play
crucial
role
and
may
contribute
to
its
prevention
or
treatment.
Calcium
vitamin
D,
extensively
studied
with
robust
scientific
evidence,
are
integral
components
of
non-pharmacological
treatment
for
this
disorder.
Nevertheless,
other
less-explored
nutritional
elements
appear
influence
metabolism.
This
review
provides
comprehensive
summary
latest
evidence
concerning
relationship
between
various
nutrients,
such
phosphorus,
magnesium,
vitamins,
phytate,
phytoestrogens;
specific
foods
like
dairy
soy,
dietary
patterns
Mediterranean
diet
osteoporosis.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 8, 2024
Thin
endometrium
(TE)
is
closely
associated
with
infertility
in
reproductive
medicine.
Estrogen
therapy
gains
unsatisfactory
outcomes.
In
this
study,
an
artificial
mucus
based
on
dopamine
(L-DOPA)-modified
hyaluronic
acid
combining
phytoestrogen
cajaninstilbene
and
rat
urinary
exosomes
(CUEHD)
constructed
for
TE
treatment
using
a
model.
the
model,
dominant
elastic
behavior
adhesive
properties
of
CUEHD
guarantee
adequate
retention,
rendering
superior
synergistic
efficacy
favorable
biosafety
characteristics.
significantly
increases
endometrial
thickness
promotes
receptivity
fertility.
Mechanistically,
estrogen
homeostasis,
inflammation
inhibition,
regeneration
are
achieved
through
crosstalk
between
ER-NLRP3-IL1β
Wnt-β
catenin-TGFβ-smad
signaling
pathways.
Moreover,
therapeutic
potential
from
human
urine
adipose
tissue-derived
stem
cells
(ADSCs)
ADSCs
also
demonstrated,
indicating
extensive
use
system.
Thus,
study
illustrates
platform
promising
implications
treatment.
Circulation,
Journal Year:
2025,
Volume and Issue:
151(7), P. 474 - 489
Published: Feb. 17, 2025
The
heart
is
a
highly
sex-biased
organ,
as
sex
shapes
innumerable
aspects
of
health
and
disease.
Sex
chromosomes
hormones
—testosterone,
progesterone,
estrogen—
establish
perpetuate
the
division
between
male
female
myocardium.
Of
these
differentiating
factors,
insulating
effects
estrogen
have
been
rigorously
interrogated
reviewed,
whereas
influence
chromosomes,
testosterone,
progesterone
remains
in
dispute
or
ill-defined.
Here,
we
synthesize
growing
evidence
that
substantially
bias
form,
function,
dysfunction
context-dependent
fashion.
discrete
protective
functions
ascribed
to
each
3
receptors
are
also
enumerated.
Subsequently,
overview
obstacles
historically
discouraged
inclusion
subjects
basic
science
such
impact
estrus
cycle
reproductive
senescence
on
data
reliability
reproducibility.
Furthermore,
weigh
utility
several
common
strategies
intercept
rescue
sex-specific
protection.
Last,
warn
compounds
animal
chow
cell
culture
interfere
with
signaling.
In
sum,
survey
controversies
challenges
stem
from
sex-inclusive
cardiovascular
research,
comparing
possible
causes
cardiac
bias,
elucidating
chromosome
hormone-dependent
processes
heart,
describing
lapses
imperil
work,
illuminating
facets
yet
unexplored
still
uncertain.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 3, 2025
Formononetin
(FMN)
is
a
common
natural
metabolite
that
can
be
extracted
and
isolated
from
some
botanical
drugs.
In
recent
years,
FMN
has
garnered
increasing
attention
due
to
its
beneficial
biological
activities.
this
paper,
we
systematically
summarize
the
sources
of
provide
comprehensive
review
pharmacological
activities
molecular
mechanisms,
co-administration,
toxicity,
derivatives,
drug
delivery
systems
in
last
5
years.
The
study
results
found
wide
range
neurological
disorders,
organ
damage
cancer,
showing
great
potential
for
clinical
application
broad
prospects.
Researchers
are
exploring
various
types
systems,
including
nanoparticle
carriers,
ligand
modifications
polymer
microspheres.
These
advanced
enhance
stability
FMN,
prolong
release
time
vivo
,
improve
targeting,
thereby
optimizing
therapeutic
efficacy
reducing
side
effects,
greatly
improving
bioavailability.
conclusion,
with
considerable
research
value,
diverse
make
it
promising
candidate
development
medical
research.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 12, 2025
Dietary
phytoestrogens
have
been
suggested
to
provide
protection
against
numerous
age-related
diseases.
However,
their
effects
on
biological
aging
remain
unclear.
In
this
study,
we
cross-sectionally
investigated
the
relationship
between
urinary
phytoestrogen
levels
and
indicators
of
using
data
from
7,981
adults
who
participated
in
National
Health
Nutrition
Examination
Survey
1999–2010.
Urinary
concentrations
six
phytoestrogens,
including
four
isoflavones
two
enterolignans,
were
measured
high-performance
liquid
chromatography
(HPLC)-tandem
mass
spectrometry
(MS)
or
HPLC-atmospheric
pressure
photoionization-tandem
MS,
standardized
creatinine.
Three
age
(BA),
namely
Klemera-Doubal
method
(KDM-BA),
phenotypic
(PA),
homeostatic
dysregulation
(HD),
derived
12
clinical
biomarkers,
advanced-BAs
calculated
quantify
differences
individuals'
BAs
chronological
age,
individuals
with
all
positive
defined
as
accelerated-aging.
Weighted
linear
regression
analysis
showed
that
after
adjusting
for
demographic
lifestyle
factors
history
chronic
diseases,
elevated
total
enterolignans
significantly
associated
less
advanced-KDM,
advanced-PA,
advanced-HD,
whereas
was
advanced-KDM
advanced-PA
but
not
advanced-HD.
logistic
higher
(highest
Q4
vs.
lowest
Q1:
OR
=
0.60,
95%CI:
0.44,
0.80;
P-trend
0.002)
(Q4
0.59,
0.45,
0.76;
<
0.001)
lower
odds
accelerated-aging,
significant
0.78,
1.08;
0.05).
Subgroup
analyses
negative
associations
attenuated
non-overweight/obese
participants
current
cigarette
smokers.
conclusion,
are
related
markers
slower
aging,
suggesting
an
anti-aging
effect
dietary
consumption,
which
warrants
further
investigations
longitudinal
interventional
settings.
