Vitamin D and Endometriosis: Is There a Mechanistic Link? DOI Creative Commons

Bethany Scout Jennings,

Martin Hewison

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 43(1)

Published: Dec. 31, 2024

Endometriosis is a prevalent chronic gynaecological disorder, but its cause still unclear, and both genetic environmental factors may contribute disease aetiology. Prominent amongst the latter vitamin D which can be obtained either by action of sunlight on skin or from dietary sources. Serum levels main circulating form D, 25-hydroxvitamin (25(OH)D), have been reported to inversely correlated with endometriosis, suggesting that D-deficiency risk factor for disease. Crucially, active 1,25-dihydroxyvitamin (1,25(OH)

Language: Английский

Tongmai Yangxin pill alleviates myocardial ischemia/reperfusion injury by regulating mitochondrial fusion and fission through the estrogen receptor alpha/peroxisome proliferator-activated receptor gamma coactivator-1 alpha signaling pathway DOI
Lu Yu,

Xu Wang,

Qian Lei

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119639 - 119639

Published: March 1, 2025

Language: Английский

Citations

1
Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants DOI Open Access
Izabela Dymanowska-Dyjak, Karolina Frankowska, Monika Abramiuk

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6298 - 6298

Published: June 7, 2024

Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility caused by a wide range abnormalities affecting the female reproductive tract, from oocyte quality impairment disturbances eutopic endometrium or mechanical resulting disease progression. Since supportive antioxidant therapies, addition surgical treatment assisted techniques (ARTs), have overall been proven be effective tools endometriosis management, objective our review was analyze role substances, including vitamins, micronutrients, N-acetylcysteine (NAC), curcumin, melatonin, and resveratrol, endometriosis-related infertility. Most these substances alleviate systemic oxidant predominance, which has expressed through decreased oxidative stress (OS) markers enhanced antioxidative defense. In addition, we demonstrated that predominant effect aforementioned inhibition development endometriotic lesions as well suppression pro-inflammatory molecules. Although can undoubtedly conclude antioxidants are beneficial fertility support, further studies explaining detailed pathways their action needed.

Language: Английский

Citations

7
Association Between the Oxidative Balance Score and Endometriosis: A Population-Based Study DOI Creative Commons
Xiaoming Zhou, Weiwei Shen,

Jue Zhu

et al.

International Journal of Women s Health, Journal Year: 2024, Volume and Issue: Volume 16, P. 1293 - 1301

Published: July 1, 2024

Purpose: To investigate the association between oxidative balance score (OBS) and endometriosis. Methods: This cross-sectional study used four cycles of National Health Nutrition Examination Survey (NHANES) (1999– 2000, 2001– 2002, 2003– 2004, 2005– 2006). OBS involved 16 dietary nutrients 4 lifestyle factors, including 5 pro-oxidants 15 anti-oxidants. According to weighted quartiles, was divided into categories: < 12.54, 12.54– 18.70, 18.71– 24.68, > 24.68. Endometriosis diagnosed based on a question from reproductive health questionnaire. Weighted multivariate logistic analysis Subgroup performed menstrual regularity female hormone use. Results: A total 5095 women were included, with 1140 (22.37%), 1232 (24.18%), 1224 (24.02%), 1499 (29.42%) in 24.68 categories, respectively. After adjusting age, race, family poverty-to-income ratio (PIR), education level, uterine fibroids, regularity, oophorectomy, use, hypertension, dyslipidemia, steroid drug, high (> 24.68) found be associated lower odds endometriosis [odds (OR) = 0.70, 95% confidence interval (CI): 0.50– 0.97, P 0.033] compared low (< 12.54). The similar result also irregular menstruation (OR 0.58, CI: 0.37– 0.91, 0.020) use 0.71, 0.52– 0.98, 0.037). Conclusion: endometriosis, especially Keywords: Oxidative score, menstruation, hormones, NHANES

Language: Английский

Citations

4
Effect of dietary patterns and nutritional supplementation in the management of endometriosis: a review DOI Creative Commons
Liyuan Zhou, Boya Liu, Xian Jian

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 12, 2025

Endometriosis is an estrogen-dependent chronic inflammatory disease which causes dysmenorrhea, pelvic pain, and infertility in women of childbearing age, significantly impacting their quality life physical mental health. The etiology endometriosis remains unclear, with oxidative stress inflammation currently thought to play pivotal roles its pathophysiology. Epidemiological studies clinical trials indicate that varying dietary patterns specific nutrient supplementation can influence markers levels factors related pathways, potentially the progression endometriosis. In this review, we summarize thoroughly examine current understanding effect treating This study suggests nutrients may prevent occurrence by modulating factors, regulating angiogenesis, influencing metabolism estrogen pathways. findings might provide new insights into treatment patients potential benefits

Language: Английский

Citations

0
Association of composite dietary antioxidant index and endometriosis risk in reproductive—age women: a cross-sectional study using big data-machine learning approach DOI Creative Commons

Wenxin Chen,

Kui Xiao,

Chenyu Zhou

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 27, 2025

Background Endometriosis (EM) is a chronic gynecological disorder characterized by the growth of endometrial-like tissue outside uterus, leading to pain and infertility. Recent studies suggest that antioxidants may play protective role in development EM. However, precise connection between composite dietary antioxidant index (CDAI)—a key measure antioxidants—and EM risk remains unclear. This study aims explore relationship CDAI using data from National Health Nutrition Examination Survey (NHANES), potentially guiding interventions for prevention. Methods analyzed NHANES spanning 1999 2006. To investigate EM, variety statistical techniques were employed, including weighted multiple logistic regression model, smooth curve fitting, machine learning analysis, subgroup analyses. Results After controlling potential confounding variables, results indicated an inverse (OR = 0.92, 95% CI 0.86–0.98, p 0.011). Compared participants lowest quartile (Q1), odds ratios (OR) higher other quartiles as follows: Q2 0.84, 0.45–1.57, 0.576), Q3 0.64, 0.33–1.24, 0.172), Q4 0.47, 0.26–0.87, 0.019). Among various components CDAI, changes vitamin A, E, carotene independently associated with occurrence while both LASSO RF algorithms consistently identified selenium significant factors. Furthermore, analyses did not reveal interactions age, body mass index, smoking, drinking, diabetes, or hypertension. Conclusion The findings this extensive cross-sectional indicate clear negative linear correlation American adult women. It therefore recommended women incorporate greater proportion antioxidant-rich foods into their diet assist prevention

Language: Английский

Citations

0
Harnessing Nature's Potential: Exploring Phytoestrogens in Cervical Cancer DOI Creative Commons
Alaa A. A. Aljabali, Rasha M. Bashatwah, Omar Gammoh

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100796 - 100796

Published: April 1, 2025

Language: Английский

Citations

0
The Importance of Diet in the Treatment of Endometriosis DOI Creative Commons

Joanna Szczepanik,

Małgorzata Dłużewska

Women, Journal Year: 2024, Volume and Issue: 4(4), P. 453 - 468

Published: Nov. 18, 2024

The world of science is increasingly looking for answers to the question how specific dietary components affect risk chronic diseases and assessing their potential alleviate severity individual diseases. This research concerns both assessment benefits using those nutritional models. Endometriosis, due its inflammatory nature, also a topic interest among scientists, who seek support course through proper nutrition. In endometriosis, great focused on patterns such as an anti-inflammatory diet, gluten-free low-FODMAP or Mediterranean diet. An diet primarily focuses fresh vegetables, fruits, seeds, nuts, whole grain products, healthy sources protein fats, including mono- polyunsaturated fatty acids, eliminating highly processed meat trans refined sugars. It believed that this type may contribute reducing endometriosis symptoms help reduce inflammation. aim review identify main trends in field diets supporting treatment last 5 years.

Language: Английский

Citations

1
Evaluation of dietary behaviours and physical activity of Polish women with endometriosis DOI Creative Commons
Adrianna Adamus, Katarzyna Oszajca

Medycyna Ogólna i Nauki o Zdrowiu, Journal Year: 2024, Volume and Issue: 30(2), P. 123 - 130

Published: June 28, 2024

1. Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021;397(10276):839–852. doi:10.1016/S0140-6736(21)00389-5 Kim JH, Han E. Female Pelvic Pain. Semin Reprod Med. 2018;36(2):143–151. doi:10.1055/s-0038-1676103. CrossRef Google Scholar

Language: Английский

Citations

0
Does diet influence the development and treatment of endometriosis? - A literature review DOI Creative Commons
Justyna Szpyra, Łukasz Gawlik,

Piotr Jagodowski

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 17, P. 52932 - 52932

Published: July 18, 2024

Introduction and objective: Endometriosis is a chronic disease that can cause symptoms significantly worsen the quality of life patients. Treatment methods often fail to produce satisfactory results. Therefore, there growing interest in potential role diet prevention management endometriosis. The aim review analyze available scientific literature on impact development alleviation endometriosis possibility its use clinical practice. Brief description state knowledge: Both nutrient deficiencies excesses affect health, with gene-nutrient interactions playing key progression. Nutrition alter gene expression susceptibility, making study diet's influence gynecological diseases like important. Research suggests dietary changes improve for patients Conclusions: This confirms consuming or limiting some nutrients reduce risk developing alleviate symptoms. However, are many contradictions research. nutrition still remains an unexplored area requires further investigation.

Language: Английский

Citations

0
Anti-inflammatory effects of selected dietary components on endometriosis - review DOI Creative Commons
Agata Pawłowska, Piotr Zatyka, Adam Słomczyński

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 21, P. 54047 - 54047

Published: Aug. 23, 2024

Background: Endometriosis is a chronic inflammatory disorder that among the most common gynaecological problems in women of reproductive age. The disease involves presence endometrial tissue outside uterus, which manifests as pelvic pain and infertility. main theory for its development suggests cells move into abdominal cavity during menstruation implant there. This process leads to an increase increased concentrations cytokines, chemokines prostaglandins, resulting inflammation. Objective: aim this work analyse detail available studies on anti-inflammatory effects selected dietary components such polyphenols, vitamin D omega-3 fatty acids. aims evaluate their potential future therapeutic options treatment endometriosis, with critical approach efficacy possible application disease.Materials methods: A review literature PubMed database was conducted using following phrases English: pain, diet, resveratrol, curcumin, D3, OMEGA-3 acids, polyunsaturated acidsState knowledge: Changing patterns patients endometriosis may result reduction levels markers, are typically elevated disease. Polyphenols, resveratrol show inhibit cell proliferation. Vitamin D3 shows influences angiogenesis. Omega-3 acids reduce inflammation proliferation.Conclusions: indicates offer promising properties proliferative, pain-relieving effects. Despite these results, further clinical trials needed.

Language: Английский

Citations

0