Age specific neuroprotection of curcumin is through differential modulation of brain dopamine metabolism: Insights from Drosophila model of Parkinson’s disease DOI Creative Commons

Mohamad Ayajuddin,

Abhik Das, Sarat Chandra Yenisetti

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Abstract Epidemiological studies suggest a strong linkage between exposure to environmental toxins and onset of Parkinson’s disease (PD). Rotenone is widely used pesticide known inhibitor mitochondrial complex I, that has been shown induce Parkinsonian phenotypes in various animal models. Our laboratory developed rotenone mediated ALSS Drosophila model PD which critical screen small molecules identify molecular targets dopaminergic neuroprotection for late-onset neurodegenerative diseases such as PD. Using negative geotaxis assay, qualitative quantitative analysis neurons by fluorescence microscopy further quantifying the levels dopamine its metabolites HPLC, we have assessed neurodegeneration under induced conditions employing curcumin Exposure induces mobility defects health transition phase adult Drosophila; whereas ameliorates deficits only during early but fail late phases. Probing whole fly brain using anti-tyrosine hydroxylase antibodies, illustrates it does not cause loss per se. However, leads “neuronal dysfunction” (diminished rate limiting enzyme synthesis) rescues neuronal dysfunction fails mitigate pathology life. Genotropic nutraceutical replenishes diminished specific DOPAC HVA do so phase, suggesting life phase-specific neuroprotective efficacy through differential modulation perturbations metabolism. Present study suggests limitation therapeutic agent emphasizes necessity screening putative matched models sets in.

Language: Английский

The NF-κB Pathway: Key Players in neurocognitive functions and related disorders DOI Creative Commons

Danfeng Yang,

Junwei Su,

Yeru Chen

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 984, P. 177038 - 177038

Published: Oct. 5, 2024

Language: Английский

Citations

2
Pharmacological and phytochemical review of Acmella oleracea: a comprehensive analysis of its therapeutic potential DOI Creative Commons
Asma Aktar, Md. Shimul Bhuia,

Shamim Molla

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(8)

Published: July 30, 2024

Abstract Acmella oleracea L. (Asteraceae), commonly known as the toothache plant, is a tropical herb with significant therapeutic potential. Traditionally, it has been used for its analgesic and sialagogue properties, distinctive yellow flower crest. This review addresses current gaps in understanding of pharmacological properties aims to provide comprehensive analysis A thorough literature was conducted using databases such Google Scholar, ScienceDirect, PubMed/MedLine. The findings indicate that . contains variety phytochemicals, including spilanthol, which exhibit diverse activities antioxidant, anti-inflammatory, immunomodulatory, antinociceptive, pronociceptive, antibacterial, antifungal, antidiabetic, diuretic, vasorelaxant effects. results highlight medicinal potential A. while also identifying areas further research, particularly regarding toxicological impacts on humans animals. guide future studies health benefits safety this plant.

Language: Английский

Citations

1
Antioxidant strategies and oxidative stress dynamics in chronic kidney disease: an integrative insight DOI
Ruhul Amin,

Biplab Kumer Dey,

Faruk Alam

et al.

Minerva Biotechnology and Biomolecular Research, Journal Year: 2024, Volume and Issue: 36(3)

Published: Oct. 1, 2024

Language: Английский

Citations

1
Exploring the molecular mechanisms of curcumin in modulating memory impairment in neurodegenerative disorders DOI
Yousef Baghcheghi,

Fateme Razazpour,

Faezeh Mirzaee

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 52(1)

Published: Dec. 9, 2024

Language: Английский

Citations

1
Age specific neuroprotection of curcumin is through differential modulation of brain dopamine metabolism: Insights from Drosophila model of Parkinson’s disease DOI Creative Commons

Mohamad Ayajuddin,

Abhik Das, Sarat Chandra Yenisetti

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Abstract Epidemiological studies suggest a strong linkage between exposure to environmental toxins and onset of Parkinson’s disease (PD). Rotenone is widely used pesticide known inhibitor mitochondrial complex I, that has been shown induce Parkinsonian phenotypes in various animal models. Our laboratory developed rotenone mediated ALSS Drosophila model PD which critical screen small molecules identify molecular targets dopaminergic neuroprotection for late-onset neurodegenerative diseases such as PD. Using negative geotaxis assay, qualitative quantitative analysis neurons by fluorescence microscopy further quantifying the levels dopamine its metabolites HPLC, we have assessed neurodegeneration under induced conditions employing curcumin Exposure induces mobility defects health transition phase adult Drosophila; whereas ameliorates deficits only during early but fail late phases. Probing whole fly brain using anti-tyrosine hydroxylase antibodies, illustrates it does not cause loss per se. However, leads “neuronal dysfunction” (diminished rate limiting enzyme synthesis) rescues neuronal dysfunction fails mitigate pathology life. Genotropic nutraceutical replenishes diminished specific DOPAC HVA do so phase, suggesting life phase-specific neuroprotective efficacy through differential modulation perturbations metabolism. Present study suggests limitation therapeutic agent emphasizes necessity screening putative matched models sets in.

Language: Английский

Citations

0