Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 27, 2024
Abstract
Epidemiological
studies
suggest
a
strong
linkage
between
exposure
to
environmental
toxins
and
onset
of
Parkinson’s
disease
(PD).
Rotenone
is
widely
used
pesticide
known
inhibitor
mitochondrial
complex
I,
that
has
been
shown
induce
Parkinsonian
phenotypes
in
various
animal
models.
Our
laboratory
developed
rotenone
mediated
ALSS
Drosophila
model
PD
which
critical
screen
small
molecules
identify
molecular
targets
dopaminergic
neuroprotection
for
late-onset
neurodegenerative
diseases
such
as
PD.
Using
negative
geotaxis
assay,
qualitative
quantitative
analysis
neurons
by
fluorescence
microscopy
further
quantifying
the
levels
dopamine
its
metabolites
HPLC,
we
have
assessed
neurodegeneration
under
induced
conditions
employing
curcumin
Exposure
induces
mobility
defects
health
transition
phase
adult
Drosophila;
whereas
ameliorates
deficits
only
during
early
but
fail
late
phases.
Probing
whole
fly
brain
using
anti-tyrosine
hydroxylase
antibodies,
illustrates
it
does
not
cause
loss
per
se.
However,
leads
“neuronal
dysfunction”
(diminished
rate
limiting
enzyme
synthesis)
rescues
neuronal
dysfunction
fails
mitigate
pathology
life.
Genotropic
nutraceutical
replenishes
diminished
specific
DOPAC
HVA
do
so
phase,
suggesting
life
phase-specific
neuroprotective
efficacy
through
differential
modulation
perturbations
metabolism.
Present
study
suggests
limitation
therapeutic
agent
emphasizes
necessity
screening
putative
matched
models
sets
in.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
6(8)
Published: July 30, 2024
Abstract
Acmella
oleracea
L.
(Asteraceae),
commonly
known
as
the
toothache
plant,
is
a
tropical
herb
with
significant
therapeutic
potential.
Traditionally,
it
has
been
used
for
its
analgesic
and
sialagogue
properties,
distinctive
yellow
flower
crest.
This
review
addresses
current
gaps
in
understanding
of
pharmacological
properties
aims
to
provide
comprehensive
analysis
A
thorough
literature
was
conducted
using
databases
such
Google
Scholar,
ScienceDirect,
PubMed/MedLine.
The
findings
indicate
that
.
contains
variety
phytochemicals,
including
spilanthol,
which
exhibit
diverse
activities
antioxidant,
anti-inflammatory,
immunomodulatory,
antinociceptive,
pronociceptive,
antibacterial,
antifungal,
antidiabetic,
diuretic,
vasorelaxant
effects.
results
highlight
medicinal
potential
A.
while
also
identifying
areas
further
research,
particularly
regarding
toxicological
impacts
on
humans
animals.
guide
future
studies
health
benefits
safety
this
plant.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 27, 2024
Abstract
Epidemiological
studies
suggest
a
strong
linkage
between
exposure
to
environmental
toxins
and
onset
of
Parkinson’s
disease
(PD).
Rotenone
is
widely
used
pesticide
known
inhibitor
mitochondrial
complex
I,
that
has
been
shown
induce
Parkinsonian
phenotypes
in
various
animal
models.
Our
laboratory
developed
rotenone
mediated
ALSS
Drosophila
model
PD
which
critical
screen
small
molecules
identify
molecular
targets
dopaminergic
neuroprotection
for
late-onset
neurodegenerative
diseases
such
as
PD.
Using
negative
geotaxis
assay,
qualitative
quantitative
analysis
neurons
by
fluorescence
microscopy
further
quantifying
the
levels
dopamine
its
metabolites
HPLC,
we
have
assessed
neurodegeneration
under
induced
conditions
employing
curcumin
Exposure
induces
mobility
defects
health
transition
phase
adult
Drosophila;
whereas
ameliorates
deficits
only
during
early
but
fail
late
phases.
Probing
whole
fly
brain
using
anti-tyrosine
hydroxylase
antibodies,
illustrates
it
does
not
cause
loss
per
se.
However,
leads
“neuronal
dysfunction”
(diminished
rate
limiting
enzyme
synthesis)
rescues
neuronal
dysfunction
fails
mitigate
pathology
life.
Genotropic
nutraceutical
replenishes
diminished
specific
DOPAC
HVA
do
so
phase,
suggesting
life
phase-specific
neuroprotective
efficacy
through
differential
modulation
perturbations
metabolism.
Present
study
suggests
limitation
therapeutic
agent
emphasizes
necessity
screening
putative
matched
models
sets
in.