Associations of genetic variation and mRNA expression of PDGF/PDGFRB pathway genes with coronary artery disease in the Chinese population DOI Creative Commons
Pengfei Wei,

Hankun Xie,

Junxiang Sun

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(22)

Published: Nov. 1, 2024

Abstract Platelet‐derived growth factors (PDGFs) and receptors (PDGFR) play a key role in the process of coronary atherosclerosis. We aimed to investigate association genetic variations mRNA expressions PDGF/PDGFRB pathway genes with artery disease (CAD). In this case–control study (3139 CAD vs. 3270 controls), 13 single nucleotide polymorphisms (SNPs) at five were genotyped combined construct weighted risk score (wGRS). Three hundred six pairs cases controls selected for quantification. Restricted cubic spline (RCS) analyses conducted dose–response relationship between wGRS, mRNAs CAD. Area under curve (AUC) was estimated evaluate discrimination mRNAs, traditional (TRF) The wGRS exhibited positive linear ( p linearity <0.001), medium high had 37% 50% increased compared low group = 1.5 × 10 −4 ; 5.7 −5 ). expression levels peripheral blood leukocytes all lower among patients admission than < 0.001). significant non‐linear correlations AMI, “U”‐shaped trend PDGFA , PDGFB “L”‐shaped PDGFC PDGFD PDGFRB . Adding TRF model significantly improved an AUC 0.921 (95% CI, 0.898–0.943). Genetic contribute susceptibility joint effect. down‐regulated have potential as blood‐based biomarkers discriminative value.

Language: Английский

Dan-shen Yin attenuates myocardial fibrosis after myocardial infarction in rats: molecular mechanism insights by integrated transcriptomics and network pharmacology analysis and experimental validation DOI
Xuan Gao,

Chenyang Ni,

Yingying Song

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119070 - 119070

Published: Nov. 8, 2024

Language: Английский

Citations

4
Exploring Potential Mechanism of Chuanzhi Qingyu Recipe for Vulnerable Atherosclerosis Plaques Based on Uplc-Q-Tof-Mse, Systems Biology Strategy, and Experimental Validation DOI
Jiajun Weng,

Luyao Huan,

Shiyu Zhang

et al.

Published: Jan. 1, 2025

BackgroundChuanzhi Qingyu (CZQY) recipe is a traditional Chinese medicine clinically used for the secondary prevention and treatment of cardiovascular diseases associated with atherosclerosis (AS) However, potential active components underlying molecular mechanisms require further elucidation.PurposeThis study aims to explore CZQY their action in stabilizing vulnerable AS plaques.MethodsInitially, mouse model plaques was established by inducing conditions high-fat diet. The efficacy these assessed using histological staining techniques, including HE, Oil Red O, Masson staining. Additionally, biochemical analyses, ELISA assays, small animal ultrasound technology, immunohistochemistry were employed. Subsequently, pharmaceutical ingredients identified through UPLC-Q-TOF-MSE comparing them standard reference substances. Finally, network pharmacology approach, conjunction RNA-seq utilized predict targets plaques, which subsequently validated Western blotting quantitative PCR methods.ResultsThe has been demonstrated significantly improve lipid liver function, reduce serum levels inflammation oxidative stress, markedly lower critical biomarkers plaques. Pathological indicate that decreases plaque area, accumulation while increasing collagen fiber ratio α-SMA CD68. Ultrasound assessments reveal improves vascular narrowing elasticity. Network analyses revealed primary stabilize include flavonoids, monoterpenes, diterpenes, phenolic compounds. These are involved regulation metabolism, inflammatory responses, stress extracellular matrix dynamics, cytokine activity, platelet function. analysis aorta produced results consistent findings from pharmacology. qPCR modulated protein mRNA key targets.ConclusionCZQY effectively reduces risk factors stabilizes This may be related its compounds such as terpenoids, organic acids, modulation inflammation, cell adhesion atherosclerosis. provide significant data support pharmacological research clinical applications.

Language: Английский

Citations

0
Targeted drug delivery systems for atherosclerosis DOI Creative Commons
Liangxing Tu,

Zijian Zou,

Yang Ye

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Atherosclerosis is a complex cardiovascular disease driven by multiple factors, including aging, inflammation, oxidative stress, and plaque rupture. The progression of this often covert, emphasizing the need for early biomarkers effective intervention measures. In recent years, advancements in therapeutic strategies have highlighted potential targeting specific processes atherosclerosis, such as localization, macrophage activity, key enzymes. Based on this, review discusses role targeted drugs treatment atherosclerosis. It also focuses their clinical efficacy anti-atherosclerosis ability to provide more precise approaches. findings underscore that future research can concentrate exploring newer drug delivery systems further refine enhance long-term dynamic management

Language: Английский

Citations

0
Beyond traditional uses: Unveiling the epigenetic, microbiome-modulating, metabolic, and nutraceutical benefits of Salvia officinalis in human and livestock nutrition DOI Creative Commons
Mohamed E. Abd El‐Hack, Hassan A. Rudayni, Ahmed Khalid Aldhalmi

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106843 - 106843

Published: April 25, 2025

Language: Английский

Citations

0
Morin, a matrix metalloproteinase 9 inhibitor, attenuates endothelial-to-mesenchymal transition in atherosclerosis by downregulating Notch-1 signaling DOI Creative Commons
Yuan He,

Xiao-Xuan Qin,

Mingwei Liu

et al.

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Atherosclerotic cardiovascular disease poses a significant health challenge globally. Recent findings highlight the pivotal role of endothelial-to-mesenchymal transition (EndMT) in atherosclerosis. Morin is bioflavonoid mainly extracted from white mulberry, traditional Chinese herbal medicine with anti-inflammatory and antioxidant properties. This study examines whether morin can alleviate atherosclerosis by suppressing EndMT seeks to elucidate underlying mechanism.

Language: Английский

Citations

2
OAS1 induces endothelial dysfunction and promotes monocyte adhesion through the NFκB pathway in Atherosclerosis DOI
Miao Liang, Weikang Li,

Xixi Xie

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 763, P. 110222 - 110222

Published: Nov. 19, 2024

Language: Английский

Citations

1
Associations of genetic variation and mRNA expression of PDGF/PDGFRB pathway genes with coronary artery disease in the Chinese population DOI Creative Commons
Pengfei Wei,

Hankun Xie,

Junxiang Sun

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(22)

Published: Nov. 1, 2024

Abstract Platelet‐derived growth factors (PDGFs) and receptors (PDGFR) play a key role in the process of coronary atherosclerosis. We aimed to investigate association genetic variations mRNA expressions PDGF/PDGFRB pathway genes with artery disease (CAD). In this case–control study (3139 CAD vs. 3270 controls), 13 single nucleotide polymorphisms (SNPs) at five were genotyped combined construct weighted risk score (wGRS). Three hundred six pairs cases controls selected for quantification. Restricted cubic spline (RCS) analyses conducted dose–response relationship between wGRS, mRNAs CAD. Area under curve (AUC) was estimated evaluate discrimination mRNAs, traditional (TRF) The wGRS exhibited positive linear ( p linearity <0.001), medium high had 37% 50% increased compared low group = 1.5 × 10 −4 ; 5.7 −5 ). expression levels peripheral blood leukocytes all lower among patients admission than < 0.001). significant non‐linear correlations AMI, “U”‐shaped trend PDGFA , PDGFB “L”‐shaped PDGFC PDGFD PDGFRB . Adding TRF model significantly improved an AUC 0.921 (95% CI, 0.898–0.943). Genetic contribute susceptibility joint effect. down‐regulated have potential as blood‐based biomarkers discriminative value.

Language: Английский

Citations

0