Current Pharmaceutical Design,
Journal Year:
2022,
Volume and Issue:
28(22), P. 1780 - 1797
Published: May 22, 2022
Coronavirus
disease
2019
(COVID-19)
continues
to
spread
globally
despite
the
discovery
of
vaccines.
Many
people
die
due
COVID-19
as
a
result
catastrophic
consequences,
such
acute
respiratory
distress
syndrome,
pulmonary
embolism,
and
disseminated
intravascular
coagulation
caused
by
cytokine
storm.
Immunopathology
immunogenetic
research
may
assist
in
diagnosing,
predicting,
treating
severe
storm
associated
with
COVID-19.
This
paper
reviews
immunopathogenesis
variants
that
play
role
Although
various
immune-related
genetic
have
been
investigated
relation
COVID-19,
NOD-like
receptor
protein
3
(NLRP3)
interleukin
18
(IL-18)
not
assessed
for
their
potential
significance
clinical
outcome.
Here,
we
a)
summarize
current
understanding
etiology
pathophysiology
storm;
b)
construct
analyze
protein-protein
interaction
(PPI)
networks
(using
enrichment
annotation
analysis)
based
on
NLRP3
IL18
all
genes,
which
were
established
Our
PPI
network
analyses
predict
useful
drug
targets
prevent
onset
including
key
antiviral
pathways
Toll-Like-Receptor
cascades,
signaling,
RIG-induction
interferon
(IFN)
α/β,
(IL)-1,
IL-6,
IL-12,
IL-18,
tumor
necrosis
factor
signaling;
SARS-CoV-2
innate
immune
evasion
participation
MYD88
MAVS
The
be
used
more
outcomes,
thereby
opening
door
targeted
preventive
treatments.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6508 - 6508
Published: June 13, 2024
C3
glomerulopathy
is
a
rare
disease,
characterized
by
an
abnormal
activation
of
the
complement's
alternative
pathway
that
leads
to
accumulation
component
in
kidney.
The
disease
recurs
more
than
half
kidney
transplant
recipients,
with
significant
impact
on
graft
survival.
Recurrence
primary
represents
second
cause
loss
after
organ
rejection.
In
glomerulopathy,
there
are
several
risk
factors
which
can
promote
recurrence
during
transplantation,
such
as
delayed
function,
infection
and
monoclonal
gammopathy.
All
these
events
trigger
complement
pathway.
this
review,
we
summarize
grafts
present
latest
treatment
options.
most
widely
used
treatments
for
include
corticosteroids
mycophenolate
mofetil,
already
chronically
recipients;
thus,
additional
required.
Currently,
studies
using
anti-complement
drugs
(i.e.,
eculizumab,
Ravalizumab,
avacopan)
patients
ongoing
encouraging
results.
BMJ Case Reports,
Journal Year:
2021,
Volume and Issue:
14(3), P. e242142 - e242142
Published: March 1, 2021
COVID-19
and
granulomatosis
with
polyangiitis
share
many
clinical
radiological
features,
making
it
challenging
for
clinicians
to
distinguish
between
the
two.
In
this
case
report,
we
describe
a
patient
who
was
diagnosed
in
October
2020.
One
month
later,
she
presented
persistent
fatigue,
shortness
of
breath
anaemia
worsening
renal
functions,
found
have
elevated
antineutrophil
cytoplasmic
antibodies
antiproteinase
3
antibodies,
polyangiitis.
International Journal of Biological Sciences,
Journal Year:
2021,
Volume and Issue:
17(6), P. 1497 - 1506
Published: Jan. 1, 2021
Increasing
clinical
evidence
shows
that
acute
kidney
injury
(AKI)
is
a
common
and
severe
complication
in
critically
ill
COVID-19
patients.The
older
age,
the
severity
of
infection,
ethnicity,
history
smoking,
diabetes,
hypertension,
cardiovascular
disease
are
risk
factor
for
AKI
patients.Of
them,
inflammation
may
be
key
player
pathogenesis
patients
with
COVID-19.It
highly
possible
SARS-COV-2
infection
trigger
activation
multiple
inflammatory
pathways
including
angiotensin
II,
cytokine
storm
such
as
interleukin-6
(IL-6),
C-reactive
protein
(CRP),
TGF-β
signaling,
complement
activation,
lung-kidney
crosstalk
to
cause
AKI.Thus,
treatments
by
targeting
these
molecules
monoclonal
antibody
against
IL-6
(Tocilizumab),
C3
inhibitor
AMY-101,
anti-C5
antibody,
anti-TGF-β
OT-101,
use
CRRT
represent
novel
specific
therapies
patients.
Current Pharmaceutical Design,
Journal Year:
2022,
Volume and Issue:
28(22), P. 1780 - 1797
Published: May 22, 2022
Coronavirus
disease
2019
(COVID-19)
continues
to
spread
globally
despite
the
discovery
of
vaccines.
Many
people
die
due
COVID-19
as
a
result
catastrophic
consequences,
such
acute
respiratory
distress
syndrome,
pulmonary
embolism,
and
disseminated
intravascular
coagulation
caused
by
cytokine
storm.
Immunopathology
immunogenetic
research
may
assist
in
diagnosing,
predicting,
treating
severe
storm
associated
with
COVID-19.
This
paper
reviews
immunopathogenesis
variants
that
play
role
Although
various
immune-related
genetic
have
been
investigated
relation
COVID-19,
NOD-like
receptor
protein
3
(NLRP3)
interleukin
18
(IL-18)
not
assessed
for
their
potential
significance
clinical
outcome.
Here,
we
a)
summarize
current
understanding
etiology
pathophysiology
storm;
b)
construct
analyze
protein-protein
interaction
(PPI)
networks
(using
enrichment
annotation
analysis)
based
on
NLRP3
IL18
all
genes,
which
were
established
Our
PPI
network
analyses
predict
useful
drug
targets
prevent
onset
including
key
antiviral
pathways
Toll-Like-Receptor
cascades,
signaling,
RIG-induction
interferon
(IFN)
α/β,
(IL)-1,
IL-6,
IL-12,
IL-18,
tumor
necrosis
factor
signaling;
SARS-CoV-2
innate
immune
evasion
participation
MYD88
MAVS
The
be
used
more
outcomes,
thereby
opening
door
targeted
preventive
treatments.
