SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review DOI Open Access
Andrea Marıno, Giovanni Cacciaguerra, Serena Spampinato

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 20(5)

Published: March 27, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection usually affects the system; however, a number of atypical manifestations this disease have also been reported, especially in children. The present study reports case 12-year-old presenting with right unilateral parotitis and sialadenitis SARS-CoV-2 infection. young patient, after 3-day history fever, was brought to our clinic (Polyclinic University Hospital 'G. Rodolico', Catania, Italy) for sudden onset accompanied by hyperaemia skin, which tender touch. molecular swab positive; ultrasound affected region showed an increase volume parotid sublingual gland reactive lymph nodes compatible sialadenitis. This suggests that, Coronavirus 2019 pandemic, should be included differential diagnosis along mumps flue. Notably, panel serology other potential causes are needed parotitis-like disease.

Language: Английский

Covid‐19 and oral diseases: Crosstalk, synergy or association? DOI Open Access
Daniela Atili Brandini,

Aline Satie Takamiya,

Pari Thakkar

et al.

Reviews in Medical Virology, Journal Year: 2021, Volume and Issue: 31(6)

Published: March 1, 2021

Summary The coronavirus disease 2019 (Covid‐19) is a viral infection caused by severe acute respiratory syndrome 2 (SARS‐CoV‐2) that clinically affects multiple organs of the human body. Cells in oral cavity express entry receptor angiotensin‐converting enzyme allows replication and may cause tissue inflammation destruction. Recent studies have reported Covid‐19 patients present manifestations with clinical aspects. In this review, we aim to summarise main signs symptoms cavity, its possible association diseases, plausible underlying mechanisms hyperinflammation reflecting crosstalk between diseases. Ulcers, blisters, necrotising gingivitis, opportunistic coinfections, salivary gland alterations, white erythematous plaques gustatory dysfunction were most Covid‐19. general, lesions appear concomitant loss smell taste. Multiple reports show evidences necrotic/ulcerative gingiva, blisters hypergrowth pathogens. SARS‐CoV‐2 exhibits tropism for endothelial cells Covid‐19‐mediated endotheliitis can not only promote tissues but also facilitate virus spread. addition, elevated levels proinflammatory mediators infectious impair homeostasis delayed resolution. This suggests potential immune‐mediated pathways pathogenesis. Interestingly, few suggest recurrent herpetic higher bacterial growth subjects, indicating virus/bacteria interaction. Larger cohort comparing negative positive subjects will reveal manifestation on health role exacerbating infection.

Language: Английский

Citations

95
condition of the oral cavity in patients who have had a viral infection COVID-19 DOI Open Access

Avzal Nigmatullaevich Akbarov,

Davron Nigman Ugli Xabilov

International journal of health & medical sciences, Journal Year: 2021, Volume and Issue: 4(4), P. 381 - 383

Published: Dec. 9, 2021

Coronavirus COVID-19 is the cause of severe respiratory pathology and a dangerous disease, proceeding in various clinical forms with varying degrees severity. This scientific paper presents literature review latest collected data on course novel coronavirus infection its manifestations oral cavity during illness after convalescence. The transmission routes disease main symptoms are also described. All healthcare systems world have been tasked prompt diagnosis infection, specialized medical care rehabilitation. In COVID 19 (SARS-CoV-2), changes OOM not primary cause, but manifested as result drug treatment progression, despite fact that one sources entry gate for infection.

Language: Английский

Citations

80
Establishing the prevalence of common tissue-specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection DOI Creative Commons
Alex Richter, Adrian M. Shields,

Abid Karim

et al.

Clinical & Experimental Immunology, Journal Year: 2021, Volume and Issue: 205(2), P. 99 - 105

Published: June 3, 2021

Summary Coronavirus 19 (COVID-19) has been associated with both transient and persistent systemic symptoms that do not appear to be a direct consequence of viral infection. The generation autoantibodies proposed as mechanism explain these symptoms. To understand the prevalence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we investigated frequency specificity clinically relevant in 84 individuals previously infected SARS-CoV-2, suffering from COVID-19 varying severity convalescent setting. These were compared results 32 who on intensive therapy unit (ITU) for non-COVID reasons. We demonstrate higher ITU group non-COVID-19 disease control patients also found serum 3–5 months post-COVID-19 Non-COVID displayed diverse pattern autoantibodies; contrast, groups had more restricted panel including skin, skeletal muscle cardiac antibodies. Our infection SARS-CoV-2 is detection limited profile tissue-specific autoantibodies, detectable using routine clinical immunology assays. Further studies are required determine whether specific or phenomenon arising infections significance autoantibodies.

Language: Английский

Citations

71
Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular Aspects DOI Open Access
Agnieszka Droździk, Marek Droździk

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1431 - 1431

Published: Jan. 27, 2022

This review article was designed to evaluate the existing evidence related molecular processes of SARS-CoV-2 infection in oral cavity. The World Health Organization stated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and transmission is produced by droplets aerosols from cavity infected patients. structures, keratinized non-keratinized mucosa, salivary glands' epithelia express entry factors, especially angiotensin converting enzyme Type (ACE2) transmembrane serine protease (TMPRSS2). Replication virus cells leads local systemic spread, cellular damage associated with clinical signs symptoms disease Saliva, both acellular fractions, holds particles contributes COVID-19 transmission. also presents information about factors modifying potential possible pharmacotherapeutic interventions, which may confine PubMed Scopus databases were used search for suitable keywords such as: SARS-CoV-2, COVID-19, infection, saliva, crevicular fluid, gland, tongue, periodontium, gingiva, dental pulp, ACE2, TMPRSS2, Furin, diagnosis, topical treatment, vaccine words relevant publications up 28 December 2021. Data extraction quality evaluation articles performed two reviewers, 63 included final review.

Language: Английский

Citations

48
Oral Manifestations of COVID-19: Updated Systematic Review With Meta-Analysis DOI Creative Commons
Javier Aragoneses, Ana Suárez, Juan Algar

et al.

Frontiers in Medicine, Journal Year: 2021, Volume and Issue: 8

Published: Aug. 25, 2021

There is increasing evidence for oral lesions and manifestations of COVID-19. The aim this meta-analysis was to investigate the types COVID-19 their prevalence. PubMed/Medline, Scopus, Web Science, Google Scholar databases were used search publications on in patients with PCR-confirmed A total 310 records selected, 74 included. Oral classified according etiologies, including iatrogenic caused by intubation opportunistic infections. Of included studies, 35 reported probably severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) infection. Meta-analysis prevalence data aphthous indicated high heterogeneity, while xerostomia revealed a pooled prevalence, considerable heterogeneity. In conclusion, yielded heterogeneity between studies: 0.33 (95% CI 0.11–0.60), 0.44 0.36–0.52) 0.10 0.01–0.24). addition, gap regarding identified need further observational studies focusing issue causal relationships highlighted.

Language: Английский

Citations

54
Antiviral potential of nanoparticles for the treatment of Coronavirus infections DOI
Joy Sarkar,

Sunandana Das,

Sahasrabdi Aich

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2022, Volume and Issue: 72, P. 126977 - 126977

Published: March 27, 2022

Language: Английский

Citations

38
Oral health conditions and COVID-19: A systematic review and meta-analysis of the current evidence DOI Creative Commons
Xiang Qi, Mary E. Northridge,

Mengyao Hu

et al.

Aging and Health Research, Journal Year: 2022, Volume and Issue: 2(1), P. 100064 - 100064

Published: March 1, 2022

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the importance of understanding underlying conditions that lead to COVID-19. Oral health systemic implications in maintenance a healthy state. This study aimed summarize evidence on prevalence oral participants with COVID-19 and assess associations between related outcomes.

Language: Английский

Citations

36
An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics DOI Creative Commons
Matt Spick, Holly-May Lewis,

Cécile Frampas

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: July 13, 2022

The majority of metabolomics studies to date have utilised blood serum or plasma, biofluids that do not necessarily address the full range patient pathologies. Here, correlations between metabolites, salivary metabolites and sebum lipids are studied for first time. 83 COVID-19 positive negative hospitalised participants provided alongside saliva samples analysis by liquid chromatography mass spectrometry. Widespread alterations serum-sebum lipid relationships were observed in versus controls. There was also a marked correlation immunostimulatory hormone dehydroepiandrosterone sulphate cohort. analysed herein compared terms their ability differentiate from controls; performed best multivariate (sensitivity specificity 0.97), with dominant changes triglyceride bile acid levels, concordant other identifying dyslipidemia as hallmark infection. Sebum well 0.92; 0.84), performing worst 0.78; 0.83). These findings show skin profiles coincide dyslipidaemia serum. work signposts potential integrated biofluid analyses provide insight into whole-body atlas pathophysiological conditions.

Language: Английский

Citations

30
Herpesviruses and SARS-CoV-2: Viral Association with Oral Inflammatory Diseases DOI Creative Commons
Jonathan M. Banks, Kristelle J. Capistrano, Daniela Atili Brandini

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(1), P. 58 - 58

Published: Jan. 7, 2024

The oral cavity is a niche for diverse microbes, including viruses. Members of the Herpesviridae family, comprised dsDNA viruses, as well severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an ssRNA virus, are among most prevalent viruses infecting cavity, and they exhibit clinical manifestations unique to tissues. Viral infection mucosal epithelia triggers immune response that results in prolonged inflammation. systemic disease HHV have been researched extensively, several recent studies illuminated relationship between inflammatory diseases. Burgeoning evidence suggests manifestation SARS-CoV-2 includes xerostomia, dysgeusia, periodontal disease, mucositis, opportunistic viral bacterial infections, collectively described post-acute sequelae COVID-19 (PASC). These could be result intensified responses initially due copious production proinflammatory cytokines: so-called "cytokine storm syndrome", facilitating widespread non-oral tissue damage. This review explores interplay HHV, SARS-CoV-2, diseases such periodontitis, endodontic peri-implantitis. Additionally, discusses proper diagnostic techniques identifying how diagnostics can lead improved overall patient health.

Language: Английский

Citations

7
Advances in the relationship between periodontopathogens and respiratory diseases (Review) DOI Creative Commons

Zhiyi Zhang,

Siyi Wen,

Jiaohong Liu

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 29(3)

Published: Jan. 17, 2024

Periodontitis is a common chronic inflammatory and destructive disease in the mouth considered to be associated with systemic diseases. Accumulating evidence has suggested that periodontitis risk factor for pulmonary diseases such as pneumonia, obstructive (COPD), asthma, coronavirus 2019 (COVID‑19) lung cancer. The presence of periodontal pathogens been detected samples from variety Periodontal can involved by promoting adhesion invasion respiratory pathogens, regulating apoptosis epithelium inducing overexpression mucin disrupting balance immune systemin cells. Additionally, measures control plaque maintain health tissue decrease incidence adverse events. This suggests close association between present study aimed review clinical COPD, COVID‑19 cancer, propose possible mechanism potential role linking disease. could provide direction further research on novel ideas diagnosis treatment management these two

Language: Английский

Citations

6