Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 20, 2025

Objective This research aimed to analyze the impact of hemorrhagic fever with renal syndrome (HFRS) acute pancreatitis (AP) on severity and prognosis patients, screen risk factors HFRS AP, establish a nomogram model.

Language: Английский

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Construction of Genetically Engineered Escherichia coli Cell Factory for Enhanced Cadmium Bioaccumulation in Wastewater

Water, Journal Year: 2024, Volume and Issue: 16(13), P. 1759 - 1759

Published: June 21, 2024

The heavy metal cadmium poses severe threats to both ecosystems and human health. Utilizing genetic engineering enhance the microbial capability for efficient accumulation has emerged as a pivotal research direction. This study constructed genetically engineered bacterium capable of expressing multivalent phytochelatins with self-assembly ability explored its efficacy in adsorption. Molecular biology techniques were adopted fuse recombinant ferritin (rHF) gene synthetic phytochelatin (EC) gene, known robust adsorption capacity metals. expression vector was constructed. Escherichia coli (E. coli) served host cell express nanochelator rHF-ECs tailored high-efficiency results reveal successful soluble fusion protein E. cells, forming self-assembled nanoparticles size about 13 nm, target rHF-EC20 (monomer) could adsorb approximately 9.2 μmol Cd2+ vitro. Moreover, this strain demonstrated across temperature range 16–45 °C pH 5–9, optimal performance observed at 7.0 37 °C. Compared control strain, BL21 (FLE), nano-chelating peptides, achieves an rate 80% 60 min, resulting 18% increase enrichment efficiency. maximum reached 12.62 mg per gram dry weight. work indicated that synthesis chelating peptides cells efficiently bioaccumulation cadmium, which renders novel avenues methodologies addressing pollution, offering promising prospects environmental remediation.

Language: Английский

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Ferritin’s Role in Infectious Diseases: Exploring Pathogenic Mechanisms and Clinical Implications

New Microbes and New Infections, Journal Year: 2025, Volume and Issue: unknown, P. 101582 - 101582

Published: March 1, 2025

Ferritin, an iron storage protein, is crucial for maintaining metabolism balance throughout the body and serves as a key biomarker evaluating body's reserves. Reduced ferritin levels typically indicate deficiency, whereas elevated acute inflammatory response in infectious diseases. Recent research has established significant link between disease severity prognosis. The concept of hyperferritinemic syndrome underscored ferritin's role pathogenic mediator. During infections, not only inflammation but also exerts pro-inflammatory functions, which factor perpetuating vicious cycle. This review offers comprehensive exploration ferritin, covering its structural characteristics, regulatory mechanisms, how diverse pathogens modulate ferritin. Understanding pivotal diseases essential identifying novel therapeutic prospects enhancing management prevention.

Language: Английский

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Natural products and ferroptosis: A novel approach for heart failure management

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156783 - 156783

Published: April 18, 2025

Language: Английский

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Mechanism of ferroptosis in heart failure: The role of the RAGE/TLR4-JNK1/2 pathway in cardiomyocyte ferroptosis and intervention strategies

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102770 - 102770

Published: May 1, 2025

Language: Английский

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Hematologic cancers and infections: how to detect infections in advance and determine the type?

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 4, 2024

Infection is one of the leading causes death in patients with hematologic cancers. Hematologic cancer compromised immune systems are already susceptible to infections, which come on even more rapidly and difficult control after they develop neutrophil deficiencies from high-dose chemotherapy. After have developed an infection, determination type infection becomes a priority for clinicians. In this review, we summarize biomarkers currently used prediction infections cancers; procalcitonin, CD64, cytokines, CD14 et al. can be determine bacterial (1-3)-β-D-glucan galactomannan as fungal infections. We also focused use metagenomic next-generation sequencing cancers, has excellent clinical value detect microorganisms that cannot detected by conventional testing methods such blood cultures. Of course, not yet but could future research direction, e.g., human lipocalin, serum amyloid A, heparin-binding protein Finally, clinicians need combine multiple biomarkers, patient’s condition, local susceptibility many other factors make infection.

Language: Английский

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Inhibition of JNK signaling attenuates photoreceptor ferroptosis caused by all-trans-retinal

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 227, P. 179 - 189

Published: Dec. 4, 2024

Language: Английский

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