Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2937 - 2937

Published: Feb. 2, 2023

Piperidines are among the most important synthetic fragments for designing drugs and play a significant role in pharmaceutical industry. Their derivatives present more than twenty classes of pharmaceuticals, as well alkaloids. The current review summarizes recent scientific literature on intra- intermolecular reactions leading to formation various piperidine derivatives: substituted piperidines, spiropiperidines, condensed piperidinones. Moreover, applications natural piperidines were covered, latest advances discovery biological evaluation potential containing moiety. This is designed help both novice researchers taking their first steps this field experienced scientists looking suitable substrates synthesis biologically active piperidines.

Language: Английский

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A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds

RSC Advances, Journal Year: 2020, Volume and Issue: 10(54), P. 32740 - 32820

Published: Jan. 1, 2020

Metal nanoparticle (MNP)-catalyzed synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds.

Language: Английский

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Green synthesis of CuFe2O4 nanoparticles mediated by Morus alba L. leaf extract: Crystal structure, grain morphology, particle size, magnetic and catalytic properties in Mannich reaction

Ceramics International, Journal Year: 2021, Volume and Issue: 47(15), P. 21373 - 21380

Published: April 19, 2021

Language: Английский

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Green synthesis and characterization of mixed-phase Fe2O3 nanorods as a novel magnetically recoverable heterogeneous catalyst for Biginelli synthesis

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1283, P. 135246 - 135246

Published: Feb. 26, 2023

Language: Английский

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Magnetic nanocatalysts as multifunctional platforms in cancer therapy through the synthesis of anticancer drugs and facilitated Fenton reaction

Journal of Advanced Research, Journal Year: 2020, Volume and Issue: 30, P. 171 - 184

Published: Dec. 5, 2020

Heterocyclic compounds have always been used as a core portion in the development of anticancer drugs. However, there is pressing need for developing inexpensive and simple alternatives to high-cost complex chemical agents-based catalysts large-scale production heterocyclic compounds. Also, some smart platforms cancer treatment based on nanoparticles (NPs) which facilitate Fenton reaction widely explored by different scientists. Magnetic NPs not only can serve synthesis with potential properties, but also are agents targeting cells inducing reactions. Therefore, this review we aim present an updated summary reports related main clinical or basic application research progress magnetic well their Afterwards, specific tumor microenvironment (TME)-responsive nanocatalysts through triggering Fenton-like reactions were surveyed. Finally, ignored factors design nanocatalysts- triggered reaction, challenges future perspective nanocatalysts-assisted selective therapy discussed. Key Scientific Concepts Review: This may pave way well-organized translation from bench bedside.

Language: Английский

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Low-temperature wet chemistry synthetic approaches towards ferrites

Inorganic Chemistry Frontiers, Journal Year: 2020, Volume and Issue: 7(18), P. 3282 - 3314

Published: Jan. 1, 2020

Solution chemistry allows the crystallisation of range iron oxides, including MFe₂O₄spinels, MFeO₃perovskites and hexaferrites, such as BaFe₁₂O₁₉, with nanoscale crystallinity properties suitable for fields catalysis electronics.

Language: Английский

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Investigation of an enhanced Z-scheme magnetic recyclable BiVO4/GO/CoFe2O4 photocatalyst with visible-light-driven for highly efficient degradation of antibiotics

Journal of Solid State Chemistry, Journal Year: 2022, Volume and Issue: 314, P. 123379 - 123379

Published: July 1, 2022

Language: Английский

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Supported Metal Catalysts for the Synthesis of N-Heterocycles

Catalysts, Journal Year: 2022, Volume and Issue: 12(1), P. 68 - 68

Published: Jan. 9, 2022

Nitrogen-containing heterocycles are important scaffolds for a large number of compounds with biological, pharmaceutical, industrial and optoelectronic applications. A wide range different methodologies the preparation N-heterocycles based on metal-catalyzed cyclization suitable substrates. Due to growing interest in Green Chemistry criteria over past two decades, use supported metal catalysts has become central topic Organic Chemistry. Here we will give critical overview all solid applied synthesis N-heterocycles, following systematic approach as function type support: (i) inorganic matrices; (ii) organic (iii) hybrid inorganic-organic matrices. In particular, try emphasize effective heterogeneity recyclability described catalysts, specifying which studies were carried out order evaluate these aspects.

Language: Английский

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Glycine and its derivatives catalyzed one-pot multicomponent synthesis of bioactive heterocycles

Synthetic Communications, Journal Year: 2022, Volume and Issue: 52(16), P. 1635 - 1656

Published: June 29, 2022

Glycine is a commercially available, mild, less toxic, zwitterionic amino acid. The present review summarizes all the reported protocols related to one-pot multicomponent synthesis of structurally diverse biologically promising heterocyclic scaffolds using catalytic amount glycine or its complexes as catalyst under various reaction conditions.

Language: Английский

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Synthesis of 1H‐Isochromenes, 4H‐Chromenes and Orthoaminocarbonitrile Tetrahydronaphthalenes by CaMgFe₂O₄ Base Nanocatalyst

ChemistrySelect, Journal Year: 2020, Volume and Issue: 5(8), P. 2627 - 2633

Published: Feb. 27, 2020

Abstract Designing protocols for the preparation of nanocatalyst in order to increase yield an organic reaction is a challenging task modern chemistry. CaMgFe 2 O 4 base that prepared through sol‐gel method. This has used synthesis 1H‐isocromenes, 4H‐chromenes and ortho‐aminocarbonitrile tetrahydronaphthalenes multi‐component reactions. The starting materials all reactions are cyclohexanone, benzaldehyde malononitrile followed with Michael addition cyclization. Therefore, different multicomponent from same arranged by using nanocatalyst. catalyst identified XRD, EDX, SEM, VSM XPS techniques compounds recognized melting point, FT‐IR, 1 H NMR 13 C analyses.

Language: Английский

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