Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
366(4), P. 830 - 837
Published: Dec. 19, 2023
Abstract
Ortho
‐directed
electrochemical
C−H
functionalization
of
aromatics
with
boron‐based
coupling
partners
has
been
achieved
under
ruthenium
catalysis
through
an
oxidatively
induced
reductive
elimination
mechanism.
Our
method
provides
a
single
set
conditions
delivering
arylation,
alkenylation
and
methylation,
yielding
ortho
‐functionalized
products
good
functional
group
tolerance,
including
examples
late‐stage
in
synthetically
useful
yields.
By
harnessing
electricity
as
‘green’
oxidant,
this
circumvents
the
need
for
stoichiometric
quantities
chemical
oxidants,
enhancing
our
sustainability
metrics.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(4), P. 2334 - 2346
Published: Jan. 1, 2025
Benzo-fused
γ-lactams
are
fundamental
in
medicinal
chemistry,
acting
as
essential
elements
for
various
therapeutic
agents
due
to
their
structural
adaptability
and
capability
enhance
biological
activity.
Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(12), P. RCR5104 - RCR5104
Published: Dec. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
A
new
mode
of
carbon-carbon
bond
formation
via
electrophilic
activation
a
C-H
has
been
developed
in
the
context
copper-catalyzed
anti-selective
silylative
cyclization
benzylacetylenes
with
silylboronates
for
synthesis
2-silyl-1H-indenes.
The
reaction
proceeds
high
regioselectivity
various
substituted
benzylacetylenes,
and
resulting
products
could
be
further
functionalized.
arene
that
undergoes
acts
as
an
electrophile
release
hydride
under
redox
neutral
conditions,
mechanism
was
probed
by
deuterium-labeling
experiments
density
functional
theory
calculations.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(18), P. 3756 - 3761
Published: April 28, 2024
Phenazines,
crucial
constituents
of
nitrogen-containing
heterocycles,
widely
exist
in
functional
compounds.
Herein,
we
report
an
anodic
oxidative
(4
+
2)
cyclization
between
anilines
and
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(36)
Published: Sept. 1, 2024
Abstract
β‐Ketosulfones
were
synthesized
from
enol
acetates
and
sodium
sulfinates
under
electrochemical
conditions.
The
starting
can
act
both
as
the
supporting
electrolyte
source
of
S‐centered
radicals,
allowing
electrolysis
to
proceed
without
external
salt.
Side
reactions
acetates’
oxidation
are
not
observed,
developed
process
is
quite
selective.
proposed
sulfonylation
compatible
with
a
wide
range
initial
sulfinates.
On
basis
literature
data,
control
experiments,
CV
studies,
presumable
reaction
pathway
suggested.
key
intermediates
sulfonyl
radical,
C‐centered
benzylic
β‐acetoxy‐β‐hydroxysulfone.
ACS Catalysis,
Journal Year:
2023,
Volume and Issue:
13(14), P. 9352 - 9365
Published: June 29, 2023
The
merging
of
transition-metal-catalyzed
C–H
bond
activation
with
electro-oxidation
has
evolved
into
an
appealing
protocol
for
oxidative
functionalization.
Nevertheless,
specific
effects
the
process
on
reaction
mechanism
transition-metal
catalysis
have
rarely
been
investigated.
Herein,
we
present
a
comprehensive
computational
study
rhodium-catalyzed
electrochemical
phosphorylation
2-phenylpyridine
by
diphenylphosphine
oxide
to
reveal
mechanistic
details.
three
major
chemical
processes,
i.e.,
activation,
P–H
and
reductive
elimination/C–P
formation,
were
thoroughly
addressed
considering
steps
at
Rh(III),
Rh(IV),
Rh(V)
oxidation
states.
calculations
demonstrated
that
prefers
take
place
Rh(III)
state,
Rh(IV)
elimination
state.
Without
oxidation,
total
barrier
occurring
center
is
unsurmountable
under
experimental
temperature.
insights
disclosed
in
are
expected
be
beneficial
understanding
electro-oxidative
