Novel Pt (II) Complexes With Anticancer Activity Against Pancreatic Ductal Adenocarcinoma Cells DOI Creative Commons
Erika Stefàno, Gianluca Rovito, Luca Giulio Cossa

et al.

Bioinorganic Chemistry and Applications, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive type of solid tumor that becoming more common. cis ‐[PtCl 2 (NH 3 ) ] (in short cisplatin or CDDP) has been shown to be effective in treating various cancers, including PDAC. However, the development resistance chemotherapy drugs created need for synthesis new anticancer agents. Platinum‐based containing bidentate ligand phenanthroline have found strong antitumor activity due their ability cause DNA damage. In this study, we examined two Pt (II) cationic complexes, [Pt( η 1 ‐C H 4 OR) (DMSO) (phen)] + Pt‐EtORSOphen; R = Me, ; Et, ), inhibit growth and spread BxPC‐3 PDAC cells, comparison CDDP. The length alkyl chain its associated lipophilic properties did not affect effects complexes cells. it appear influence rapid loss mitochondrial membrane potential (ΔΨ M suggesting these could potentially used as mitochondria‐targeted cations therapy.

Language: Английский

Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development DOI
Ashish Yadav, Samya Banerjee,

Arif Ali Mandal

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7161 - 7181

Published: Feb. 20, 2025

Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.

Language: Английский

Citations

0
Exploring Anticancer Activity and DNA Binding of Metal (II) Salicylaldehyde Schiff Base Complexes: A Convergence of Experimental and Computational Perspectives DOI Creative Commons
Ibrahim Waziri, Sheldon Sookai, Tunde L. Yusuf

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 9, 2025

ABSTRACT Metal complexes derived from salicylaldehyde‐based Schiff bases are among the frontrunners in pursuit of precise and potent cancer treatments due to their remarkable prowess. In this study, base ( HL ) was prepared via a reaction between 2‐amino‐5‐benzonitrile salicylaldehyde. Subsequently, further reacted with Ni (II), Co Cu (II) Pd ions using respective metal salts obtain homoleptic mononuclear C1 – C4 ). The composition were determined 1 H 13 C NMR, UV–Vis, FTIR, CHN, SEM–EDX HRMS analyses. addition, structural geometries , C3 solid state single crystal X‐ray diffraction analysis corroborate mentioned characterization techniques employed. stability compounds assessed through time‐dependent UV–vis spectroscopy, revealing that C2 exhibited highest under experimental conditions. anticancer effects tested on breast cell lines (MCF‐7) MTT, LDH ATP assays. Both displayed potential cytotoxicity MCF‐7 line, which better inhibition effect than standard chemotherapeutic agent, doxorubicin (DOX), IC 50 43.08 μM. We postulate mechanism by may function is binding DNA = 0.114 (± 0.02) × 10 4 intercalation (shown UV‐CD UV‐LD spectroscopy) at AT rich sites. These data corroborated silico extra precision (XP) docking molecular dynamic (MD) simulations.

Language: Английский

Citations

0
A mechanism – based perspective on the interplay of new drug candidate with biomolecules DOI

Roghayeh Behroozi,

Effat Dehghanian, Hassan Mansouri‐Torshizi

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139700 - 139700

Published: Aug. 23, 2024

Language: Английский

Citations

2
Recent advances in Rh(III)-based anticancer complexes DOI
Souvik Saha, Rajesh Kushwaha,

Apurba Mandal

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 525, P. 216306 - 216306

Published: Nov. 22, 2024

Language: Английский

Citations

2
Gold(I) Complexes of the Type [AuL{κC-2-C6H4P(S)Ph2}] [L = PTA, PPh3, PPh2(C6H4-3-SO3Na) and PPh2(2-py)]: Synthesis, Characterisation, Crystal Structures, and In Vitro and In Vivo Anticancer Properties. DOI

T. Srinivasa Reddy,

Steven H. Privér, Ruchika Ojha

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 281, P. 117007 - 117007

Published: Oct. 30, 2024

Language: Английский

Citations

0
Exploring Sex-Based Neuropsychological Outcomes in Pediatric Brain Cancer Survivors: A Pilot Study DOI Creative Commons
Chiara Colliva, Veronica Rivi, Pierfrancesco Sarti

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(11), P. 289 - 289

Published: Nov. 11, 2024

Background: The increasing survival rates among pediatric cancer patients underscore the critical need to understand long-term psychosocial impacts of treatments, such as cisplatin and carboplatin. While these treatments are lifesaving, they may pose risks neurodevelopmental processes. Despite substantial body research highlighting cognitive impairments associated with there remains a gap in understanding how effects differ by sex. As sex differences could inform tailored interventions support mechanisms for affected individuals, this pilot study aimed examine neuropsychological outcomes treated brain and/or Methods: Our employed rigorous/structured assessments evaluate executive functions survivors We utilized BRIEF TOL tests assess key domains function, including inhibitory control, flexibility, problem-solving abilities. Additionally, factors were evaluated using Resiliency Scale measure resilience PAT test family risk. Results: In our cohort 17 patients, significant emerged, where males outperformed females areas impulse regulation, strategic planning. Conclusions: These findings highlight complexity survivors. Understanding sex-specific is essential developing that optimize outcomes. Future should focus on larger cohorts longitudinal studies validate guide targeted improve survivorship

Language: Английский

Citations

0
Novel Pt (II) Complexes With Anticancer Activity Against Pancreatic Ductal Adenocarcinoma Cells DOI Creative Commons
Erika Stefàno, Gianluca Rovito, Luca Giulio Cossa

et al.

Bioinorganic Chemistry and Applications, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive type of solid tumor that becoming more common. cis ‐[PtCl 2 (NH 3 ) ] (in short cisplatin or CDDP) has been shown to be effective in treating various cancers, including PDAC. However, the development resistance chemotherapy drugs created need for synthesis new anticancer agents. Platinum‐based containing bidentate ligand phenanthroline have found strong antitumor activity due their ability cause DNA damage. In this study, we examined two Pt (II) cationic complexes, [Pt( η 1 ‐C H 4 OR) (DMSO) (phen)] + Pt‐EtORSOphen; R = Me, ; Et, ), inhibit growth and spread BxPC‐3 PDAC cells, comparison CDDP. The length alkyl chain its associated lipophilic properties did not affect effects complexes cells. it appear influence rapid loss mitochondrial membrane potential (ΔΨ M suggesting these could potentially used as mitochondria‐targeted cations therapy.

Language: Английский

Citations

0