Chloride and Acetonitrile Ruthenium(IV) Complexes: Crystal Architecture, Chemical Characterization, Antibiofilm Activity, and Bioavailability in Biological Systems

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 564 - 564

Published: Jan. 26, 2025

Due to the emergence of drug resistance, many antimicrobial medications are becoming less effective, complicating treatment infections. Therefore, it is crucial develop new active agents. This article aims explore ruthenium(IV) complexes with following formulas: (Hdma)2(HL)2[RuIVCl6]·2Cl·2H2O (1), where Hdma protonated dimethylamine and L 2-hydroxymethylbenzimidazole, [RuIVCl4(AN)2]·H2O (2), AN acetonitrile. paper delves into physicochemical characteristics crystal structures these complexes, employing various techniques such as spectroscopy (IR, UV–Vis), electrochemistry (CV, DPV), X-ray crystallography. Hirshfeld surface analysis was also performed visualize intermolecular interactions. Furthermore, potential antibiofilm activity against Pseudomonas aeruginosa PAO1 investigated effect compounds on production pyoverdine, one virulence factors strain, assessed. The results show that particularly complex 1 reduces biofilm formation pyoverdine production. Additionally, bioavailability in biological systems (by fluorescence quenching human serum albumin (HSA) molecular docking studies) discussed, assessing how their chemical properties influence interactions molecules therapeutic applications.

Language: Английский

Dichloro-Bis(1-cinnamyl-benzimidazole)-Cobalt(II)

Molbank, Journal Year: 2024, Volume and Issue: 2024(4), P. M1911 - M1911

Published: Oct. 31, 2024

Dichloro-bis(1-cinnamyl-benzimidazole)-cobalt(II) was prepared in one step using a cobalt precursor CoCl2 and corresponding substituted benzimidazole. The complex fully characterized IR, elemental analysis, mass- NMR spectroscopy. In the solid state, atom displays typical tetrahedral geometry is coordinated to two chlorine atoms benzimidazole moieties.

Language: Английский