Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma DOI Creative Commons
Hong Xie, Chia-Hao Shih,

Sulaiman Aldoohan

et al.

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 4, 2023

The hypothalamus is critical for regulation of the hypothalamic-pituitary-adrenal (HPA) axis and response to stress. Adverse childhood experience (ACE) can affect brain structure, which may contribute development posttraumatic stress disorder (PTSD) after subsequent adult trauma. It unclear, however, if ACE history particularly associated with aspects hypothalamic structure PTSD. To address this issue, present study longitudinally assessed volumes their associations early post-trauma symptoms in subjects who did or not develop PTSD during 12 months 109 (18-60 years, F/M = 75/34) completed Checklist (PCL) questionnaire symptoms, Childhood Trauma Questionnaire (CTQ) assessment, an initial MRI scan volume measurement, within 2 weeks At months, underwent a diagnosis interview using Clinician-Administered Scale (CAPS), follow-up scan. Left right at trauma negatively correlated CTQ scores. Right time mediated association between later. also remained persistently smaller from survivors developed These results suggest that be related ways adulthood.

Language: Английский

Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN): An Overview and Initial Validation DOI
George M. Slavich, Grant S. Shields

Psychosomatic Medicine, Journal Year: 2017, Volume and Issue: 80(1), P. 17 - 27

Published: Oct. 10, 2017

Numerous theories have proposed that acute and chronic stressors may exert a cumulative effect on life-span health by causing biological "wear tear," or allostatic load, which in turn promotes disease. Very few studies directly tested such models, though, partly because of the challenges associated with efficiently assessing stress exposure over entire life course. To address this issue, we developed first online system for systematically lifetime exposure, called Stress Adversity Inventory (STRAIN), describe its initial validation here.Adults recruited from community (n = 205) were administered STRAIN, Childhood Trauma Questionnaire-Short Form, Perceived Scale, as well measures socioeconomic status, personality, social desirability, negative affect, mental physical complaints, sleep quality, computer-assessed executive function, doctor-diagnosed general problems autoimmune disorders.The STRAIN achieved high acceptability was completed relatively quickly (mean 18 minutes 39 seconds; interquartile range 12-23 minutes). The structure data best fit two latent classes overall five distinct trajectories time. Concurrent associations Form Scale good (r values .147-.552). Moreover, not significantly related to personality traits desirability characteristics and, adjusted analyses, emerged measure most strongly all six cognitive outcomes assessed except current complaints (β .16-.41; risk ratios 1.02-1.04). Finally, test-retest reliability main indices 2-4 weeks excellent .904-.919).The demonstrated usability acceptability; very concurrent, discriminant, predictive validity; reliability.

Language: Английский

Citations

236

Lifetime stress exposure and health: A review of contemporary assessment methods and biological mechanisms DOI
Grant S. Shields, George M. Slavich

Social and Personality Psychology Compass, Journal Year: 2017, Volume and Issue: 11(8)

Published: Aug. 1, 2017

Life stress is a central construct in health research because it associated with increased risk for variety of serious mental and physical problems, including anxiety disorders, depression, cardiovascular disease, autoimmune Alzheimer's certain cancers, other diseases aging. In this review, we examine how lifetime exposure contributes to elevated disease risk, explore ongoing measurement scientific issues related topic. To accomplish these goals, first review existing instruments that have been developed assessing perceived stress, self-reported life events, interviewer-assessed stressors, exposure. Next, describe laboratory-based tasks used characterizing individual differences psychological biological reactivity. These methods yielded an enormous amount data showing influences the activity hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal sympathetic-adrenal-medullary immune system, such processes can turn cause allostatic load embedding effect at level human brain genome. At same time, many critical remain unresolved, discuss topics last while describing some pressing opportunities future on health.

Language: Английский

Citations

179

Cortisol and development of depression in adolescence and young adulthood – a systematic review and meta-analysis DOI Creative Commons
Zuzanna Zajkowska, Nancy Gullett, Annabel Walsh

et al.

Psychoneuroendocrinology, Journal Year: 2021, Volume and Issue: 136, P. 105625 - 105625

Published: Dec. 8, 2021

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated in development major depressive disorder (MDD) adulthood. Less work focused on role HPA depression adolescence and young adulthood globally. The aim this study was to conduct a systematic review meta-analysis worldwide research investigating relationship between cortisol, measure activity, MDD adulthood.We searched MEDLINE, PsycINFO, Cochrane Database Systematic Reviews, Web Science, Lilacs, African Journals Online, Global Health for studies which examined cortisol global youth (10-24 years old).Twenty-six were included 14 eligible meta-analysis, but only one adults their sample. Results from demonstrated that elevated morning, not evening, levels prospectively associated with later However, morning did significantly differ healthy controls individuals cross-sectional studies. Afternoon stress response also adolescents controls. Qualitative synthesis three examining nocturnal showed higher both longitudinally cross-sectionally adolescence.Our findings suggest precedes adolescence. Despite this, we find any differences other measures association Taken together, these are risk factors rather than biomarker existing MDD. This supports hyperactivity Most high-income-countries (HICs) thus further would need be conducted low- middle-income countries (LMICs) understand if our generalisable populations.

Language: Английский

Citations

104

Life Stress and Suicide in Adolescents DOI
Jeremy G. Stewart, Grant S. Shields, Erika C. Esposito

et al.

Journal of Abnormal Child Psychology, Journal Year: 2019, Volume and Issue: 47(10), P. 1707 - 1722

Published: April 26, 2019

Language: Английский

Citations

123

The Stress and Adversity Inventory for Adults (Adult STRAIN) in Brazilian Portuguese: Initial Validation and Links With Executive Function, Sleep, and Mental and Physical Health DOI Creative Commons
Milton José Cazassa, Margareth da Silva Oliveira, Chandler M. Spahr

et al.

Frontiers in Psychology, Journal Year: 2020, Volume and Issue: 10

Published: Jan. 28, 2020

It has been widely hypothesized that stressors occurring over the lifespan exert a cumulative impact on health, but little work directly tested these theories given difficulty associated with measuring stress exposure lifespan. We addressed this issue in Brazil by translating Stress and Adversity Inventory for Adults (Adult STRAIN) into Brazilian Portuguese. then examined instrument's usability acceptability; concurrent, discriminant, predictive, incremental validity; test-retest reliability. Participants were 330 adults (238 women; Mage = 32.16; range: 18-76 years old) who completed Adult STRAIN Portuguese, Childhood Trauma Questionnaire-Short Form (CTQ-SF), Perceived Scale (PSS). They also measures of socioeconomic status, personality, social desirability, negative affect, physical mental health complaints, sleep quality, executive function, doctor-diagnosed general problems autoimmune disorders. The exhibited excellent acceptability was 16 minutes 27 seconds, average. showed good concurrent validity relative to CTQ-SF PSS (r ≥ .377) discriminant validity, both without adjusting covariates. In addition, significantly predicted all outcomes assessed except function explained substantial variance above CTQ-SF, PSS, covariates assessed. Finally, reliability indices total lifetime stressor count severity outstanding (ricc .936 .953, respectively, M 34.86 days). Portuguese thus exhibits acceptability, strong predictive across variety outcomes, therefore conclude is practical, valid, reliable instrument researchers clinicians looking efficiently assess

Language: Английский

Citations

73

The Heteronormativity Theory of Low Sexual Desire in Women Partnered with Men DOI Open Access
Sari M. van Anders, Debby Herbenick, Lori A. Brotto

et al.

Archives of Sexual Behavior, Journal Year: 2021, Volume and Issue: 51(1), P. 391 - 415

Published: Aug. 23, 2021

Language: Английский

Citations

62

Stress research during the COVID-19 pandemic and beyond DOI Open Access
Lena Sophie Pfeifer, Katrin Heyers, Sebastian Ocklenburg

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 131, P. 581 - 596

Published: Sept. 29, 2021

Language: Английский

Citations

56

Current methods for stress marker detection in saliva DOI Open Access
Ginevra Giacomello,

Andreas Scholten,

Maria Kristina Parr

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2020, Volume and Issue: 191, P. 113604 - 113604

Published: Sept. 6, 2020

Language: Английский

Citations

66

The Stress and Adversity Inventory for Adolescents (Adolescent STRAIN): associations with mental and physical health, risky behaviors, and psychiatric diagnoses in youth seeking treatment DOI
George M. Slavich, Jeremy G. Stewart, Erika C. Esposito

et al.

Journal of Child Psychology and Psychiatry, Journal Year: 2019, Volume and Issue: 60(9), P. 998 - 1009

Published: March 26, 2019

Background Numerous theories have posited that stressors occurring over the lifespan may exert a cumulative effect on psychological and biological processes increase individuals’ risk for variety of mental physical health problems. Given difficulty associated with assessing lifetime stress exposure, however, few empirical studies directly tested these models psychopathology human health. Method To address this issue, we examined usability, acceptability, concurrent validity, predictive validity recently developed Stress Adversity Inventory Adolescents (Adolescent STRAIN ) in 338 youth ( M age = 15.64; 229 females) seeking treatment. Results The Adolescent achieved high acceptability was completed approximately 25 min (interquartile range: 20–32 min). Concurrent associations other measures early adversity (Childhood Trauma Questionnaire‐Short Form) interpersonal (Revised Peer Experiences Questionnaire) were very good r s .50–.59). In analyses adjusted participants’ age, sex, race, significantly depression, anxiety, anhedonia severity; general complaints; risky behavior engagement; number interviewer‐based psychiatric diagnoses (βs .16–.52; ratios 1.006–1.014). Contrary to classic which assume different similar effects health, substantial differences observed across two stressor types, twelve life domains, five core social‐psychological characteristics assessed by . Conclusions These data confirm relevance exposure multiple outcomes adolescence, can turn inform existing Because is common presenting problem hospitals clinics, also suggest possibility using generate profiles case conceptualization treatment planning purposes.

Language: Английский

Citations

63

Invisible wounds: Community exposure to gun homicides and adolescents’ mental health and behavioral outcomes DOI Creative Commons
Christine Leibbrand, Heather D. Hill, Ali Rowhani‐Rahbar

et al.

SSM - Population Health, Journal Year: 2020, Volume and Issue: 12, P. 100689 - 100689

Published: Nov. 5, 2020

Prior research has illustrated the importance of some types local community crime for adolescents' outcomes. However, we have little knowledge about extent to which gun homicides within neighborhoods affect their mental health and behavioral This is important because homicide incidents may be uniquely harmful adolescents association with behavior represent an underappreciated externality U.S.'s violence epidemic. In this study, used data on geocoded location linked restricted Fragile Families Child Wellbeing Study examine whether near homes and/or schools were associated We found that occurrence a adolescent's home or school was significantly worse symptoms anxiety depression girls and, in cases, boys. further these relationships varied depending distance schools.

Language: Английский

Citations

62