Translational Psychiatry,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Aug. 4, 2023
The
hypothalamus
is
critical
for
regulation
of
the
hypothalamic-pituitary-adrenal
(HPA)
axis
and
response
to
stress.
Adverse
childhood
experience
(ACE)
can
affect
brain
structure,
which
may
contribute
development
posttraumatic
stress
disorder
(PTSD)
after
subsequent
adult
trauma.
It
unclear,
however,
if
ACE
history
particularly
associated
with
aspects
hypothalamic
structure
PTSD.
To
address
this
issue,
present
study
longitudinally
assessed
volumes
their
associations
early
post-trauma
symptoms
in
subjects
who
did
or
not
develop
PTSD
during
12
months
109
(18-60
years,
F/M
=
75/34)
completed
Checklist
(PCL)
questionnaire
symptoms,
Childhood
Trauma
Questionnaire
(CTQ)
assessment,
an
initial
MRI
scan
volume
measurement,
within
2
weeks
At
months,
underwent
a
diagnosis
interview
using
Clinician-Administered
Scale
(CAPS),
follow-up
scan.
Left
right
at
trauma
negatively
correlated
CTQ
scores.
Right
time
mediated
association
between
later.
also
remained
persistently
smaller
from
survivors
developed
These
results
suggest
that
be
related
ways
adulthood.
Psychosomatic Medicine,
Journal Year:
2017,
Volume and Issue:
80(1), P. 17 - 27
Published: Oct. 10, 2017
Numerous
theories
have
proposed
that
acute
and
chronic
stressors
may
exert
a
cumulative
effect
on
life-span
health
by
causing
biological
"wear
tear,"
or
allostatic
load,
which
in
turn
promotes
disease.
Very
few
studies
directly
tested
such
models,
though,
partly
because
of
the
challenges
associated
with
efficiently
assessing
stress
exposure
over
entire
life
course.
To
address
this
issue,
we
developed
first
online
system
for
systematically
lifetime
exposure,
called
Stress
Adversity
Inventory
(STRAIN),
describe
its
initial
validation
here.Adults
recruited
from
community
(n
=
205)
were
administered
STRAIN,
Childhood
Trauma
Questionnaire-Short
Form,
Perceived
Scale,
as
well
measures
socioeconomic
status,
personality,
social
desirability,
negative
affect,
mental
physical
complaints,
sleep
quality,
computer-assessed
executive
function,
doctor-diagnosed
general
problems
autoimmune
disorders.The
STRAIN
achieved
high
acceptability
was
completed
relatively
quickly
(mean
18
minutes
39
seconds;
interquartile
range
12-23
minutes).
The
structure
data
best
fit
two
latent
classes
overall
five
distinct
trajectories
time.
Concurrent
associations
Form
Scale
good
(r
values
.147-.552).
Moreover,
not
significantly
related
to
personality
traits
desirability
characteristics
and,
adjusted
analyses,
emerged
measure
most
strongly
all
six
cognitive
outcomes
assessed
except
current
complaints
(β
.16-.41;
risk
ratios
1.02-1.04).
Finally,
test-retest
reliability
main
indices
2-4
weeks
excellent
.904-.919).The
demonstrated
usability
acceptability;
very
concurrent,
discriminant,
predictive
validity;
reliability.
Social and Personality Psychology Compass,
Journal Year:
2017,
Volume and Issue:
11(8)
Published: Aug. 1, 2017
Life
stress
is
a
central
construct
in
health
research
because
it
associated
with
increased
risk
for
variety
of
serious
mental
and
physical
problems,
including
anxiety
disorders,
depression,
cardiovascular
disease,
autoimmune
Alzheimer's
certain
cancers,
other
diseases
aging.
In
this
review,
we
examine
how
lifetime
exposure
contributes
to
elevated
disease
risk,
explore
ongoing
measurement
scientific
issues
related
topic.
To
accomplish
these
goals,
first
review
existing
instruments
that
have
been
developed
assessing
perceived
stress,
self-reported
life
events,
interviewer-assessed
stressors,
exposure.
Next,
describe
laboratory-based
tasks
used
characterizing
individual
differences
psychological
biological
reactivity.
These
methods
yielded
an
enormous
amount
data
showing
influences
the
activity
hypothalamic-pituitary-adrenal
axis,
hypothalamic-pituitary-gonadal
sympathetic-adrenal-medullary
immune
system,
such
processes
can
turn
cause
allostatic
load
embedding
effect
at
level
human
brain
genome.
At
same
time,
many
critical
remain
unresolved,
discuss
topics
last
while
describing
some
pressing
opportunities
future
on
health.
Psychoneuroendocrinology,
Journal Year:
2021,
Volume and Issue:
136, P. 105625 - 105625
Published: Dec. 8, 2021
Dysregulation
of
the
hypothalamic-pituitary-adrenal
(HPA)
axis
has
been
implicated
in
development
major
depressive
disorder
(MDD)
adulthood.
Less
work
focused
on
role
HPA
depression
adolescence
and
young
adulthood
globally.
The
aim
this
study
was
to
conduct
a
systematic
review
meta-analysis
worldwide
research
investigating
relationship
between
cortisol,
measure
activity,
MDD
adulthood.We
searched
MEDLINE,
PsycINFO,
Cochrane
Database
Systematic
Reviews,
Web
Science,
Lilacs,
African
Journals
Online,
Global
Health
for
studies
which
examined
cortisol
global
youth
(10-24
years
old).Twenty-six
were
included
14
eligible
meta-analysis,
but
only
one
adults
their
sample.
Results
from
demonstrated
that
elevated
morning,
not
evening,
levels
prospectively
associated
with
later
However,
morning
did
significantly
differ
healthy
controls
individuals
cross-sectional
studies.
Afternoon
stress
response
also
adolescents
controls.
Qualitative
synthesis
three
examining
nocturnal
showed
higher
both
longitudinally
cross-sectionally
adolescence.Our
findings
suggest
precedes
adolescence.
Despite
this,
we
find
any
differences
other
measures
association
Taken
together,
these
are
risk
factors
rather
than
biomarker
existing
MDD.
This
supports
hyperactivity
Most
high-income-countries
(HICs)
thus
further
would
need
be
conducted
low-
middle-income
countries
(LMICs)
understand
if
our
generalisable
populations.
Frontiers in Psychology,
Journal Year:
2020,
Volume and Issue:
10
Published: Jan. 28, 2020
It
has
been
widely
hypothesized
that
stressors
occurring
over
the
lifespan
exert
a
cumulative
impact
on
health,
but
little
work
directly
tested
these
theories
given
difficulty
associated
with
measuring
stress
exposure
lifespan.
We
addressed
this
issue
in
Brazil
by
translating
Stress
and
Adversity
Inventory
for
Adults
(Adult
STRAIN)
into
Brazilian
Portuguese.
then
examined
instrument's
usability
acceptability;
concurrent,
discriminant,
predictive,
incremental
validity;
test-retest
reliability.
Participants
were
330
adults
(238
women;
Mage
=
32.16;
range:
18-76
years
old)
who
completed
Adult
STRAIN
Portuguese,
Childhood
Trauma
Questionnaire-Short
Form
(CTQ-SF),
Perceived
Scale
(PSS).
They
also
measures
of
socioeconomic
status,
personality,
social
desirability,
negative
affect,
physical
mental
health
complaints,
sleep
quality,
executive
function,
doctor-diagnosed
general
problems
autoimmune
disorders.
The
exhibited
excellent
acceptability
was
16
minutes
27
seconds,
average.
showed
good
concurrent
validity
relative
to
CTQ-SF
PSS
(r
≥
.377)
discriminant
validity,
both
without
adjusting
covariates.
In
addition,
significantly
predicted
all
outcomes
assessed
except
function
explained
substantial
variance
above
CTQ-SF,
PSS,
covariates
assessed.
Finally,
reliability
indices
total
lifetime
stressor
count
severity
outstanding
(ricc
.936
.953,
respectively,
M
34.86
days).
Portuguese
thus
exhibits
acceptability,
strong
predictive
across
variety
outcomes,
therefore
conclude
is
practical,
valid,
reliable
instrument
researchers
clinicians
looking
efficiently
assess
Journal of Child Psychology and Psychiatry,
Journal Year:
2019,
Volume and Issue:
60(9), P. 998 - 1009
Published: March 26, 2019
Background
Numerous
theories
have
posited
that
stressors
occurring
over
the
lifespan
may
exert
a
cumulative
effect
on
psychological
and
biological
processes
increase
individuals’
risk
for
variety
of
mental
physical
health
problems.
Given
difficulty
associated
with
assessing
lifetime
stress
exposure,
however,
few
empirical
studies
directly
tested
these
models
psychopathology
human
health.
Method
To
address
this
issue,
we
examined
usability,
acceptability,
concurrent
validity,
predictive
validity
recently
developed
Stress
Adversity
Inventory
Adolescents
(Adolescent
STRAIN
)
in
338
youth
(
M
age
=
15.64;
229
females)
seeking
treatment.
Results
The
Adolescent
achieved
high
acceptability
was
completed
approximately
25
min
(interquartile
range:
20–32
min).
Concurrent
associations
other
measures
early
adversity
(Childhood
Trauma
Questionnaire‐Short
Form)
interpersonal
(Revised
Peer
Experiences
Questionnaire)
were
very
good
r
s
.50–.59).
In
analyses
adjusted
participants’
age,
sex,
race,
significantly
depression,
anxiety,
anhedonia
severity;
general
complaints;
risky
behavior
engagement;
number
interviewer‐based
psychiatric
diagnoses
(βs
.16–.52;
ratios
1.006–1.014).
Contrary
to
classic
which
assume
different
similar
effects
health,
substantial
differences
observed
across
two
stressor
types,
twelve
life
domains,
five
core
social‐psychological
characteristics
assessed
by
.
Conclusions
These
data
confirm
relevance
exposure
multiple
outcomes
adolescence,
can
turn
inform
existing
Because
is
common
presenting
problem
hospitals
clinics,
also
suggest
possibility
using
generate
profiles
case
conceptualization
treatment
planning
purposes.
SSM - Population Health,
Journal Year:
2020,
Volume and Issue:
12, P. 100689 - 100689
Published: Nov. 5, 2020
Prior
research
has
illustrated
the
importance
of
some
types
local
community
crime
for
adolescents'
outcomes.
However,
we
have
little
knowledge
about
extent
to
which
gun
homicides
within
neighborhoods
affect
their
mental
health
and
behavioral
This
is
important
because
homicide
incidents
may
be
uniquely
harmful
adolescents
association
with
behavior
represent
an
underappreciated
externality
U.S.'s
violence
epidemic.
In
this
study,
used
data
on
geocoded
location
linked
restricted
Fragile
Families
Child
Wellbeing
Study
examine
whether
near
homes
and/or
schools
were
associated
We
found
that
occurrence
a
adolescent's
home
or
school
was
significantly
worse
symptoms
anxiety
depression
girls
and,
in
cases,
boys.
further
these
relationships
varied
depending
distance
schools.