Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Advanced Materials, Journal Year: 2018, Volume and Issue: 31(6)

Published: Dec. 17, 2018

Abstract Photoacoustic (PA) imaging as a fast‐developing technique has great potential in biomedical and clinical applications. It is noninvasive modality that depends on the light‐absorption coefficient of imaged tissue injected PA‐imaging contrast agents. Furthermore, PA provides superb contrast, super spatial resolution, high penetrability sensitivity to functional characteristics by detecting acoustic wave construct images. In recent years, series agents are developed improve performance Here, progress their applications outlined. classified according components function, gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based other inorganic agents, small organic molecules, semiconducting polymer nanoparticles, nonlinear discussed. The biosensors (in sensing metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, nitrogen species) bioimaging (lymph nodes, vasculature, tumors, brain tissue) discussed detail. Finally, an outlook future research investigation significance presented.

Language: Английский

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Recent developments in 2D transition metal dichalcogenides: phase transition and applications of the (quasi-)metallic phases

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(18), P. 10087 - 10115

Published: Jan. 1, 2021

This review outlines the semiconducting-(quasi)metallic phase transition of 2D-TMDs and discusses current developments in application this unique phase. Challenges future developmental trends TMD-based systems are also highlighted.

Language: Английский

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Two-dimensional biomaterials: material science, biological effect and biomedical engineering applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(20), P. 11381 - 11485

Published: Jan. 1, 2021

To date, nanotechnology has increasingly been identified as a promising and efficient means to address number of challenges associated with public health. In the past decade, two-dimensional (2D) biomaterials, unique nanoplatform planar topology, have attracted explosive interest in various fields such biomedicine due their morphology, physicochemical properties biological effect. Motivated by progress graphene biomedicine, dozens types ultrathin 2D biomaterials found versatile bio-applications, including biosensing, biomedical imaging, delivery therapeutic agents, cancer theranostics, tissue engineering, well others. The effective utilization stems from in-depth knowledge structure-property-bioactivity-biosafety-application-performance relationships. A comprehensive summary for is still lacking. this review, we aim concentrate on state-of-the-art particular focus applications. particular, discuss design, fabrication functionalization used diverse applications based up-to-date progress. Furthermore, interactions between systems spatial-temporal scale are highlighted, which will deepen understanding underlying action mechanism aiding design improved functionalities. Finally, taking bench-to-bedside focus, conclude review proposing current crucial issues/challenges presenting future development directions advance clinical translation these emerging biomaterials.

Language: Английский

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Metallic 1T Phase Enabling MoS₂ Nanodots as an Efficient Agent for Photoacoustic Imaging Guided Photothermal Therapy in the Near‐Infrared‐II Window

Small, Journal Year: 2020, Volume and Issue: 16(43)

Published: Oct. 1, 2020

Transition metal dichalcogenide (TMD) nanomaterials, specially MoS2 , are proven to be appealing nanoagents for photothermal cancer therapies. However, the impact of crystal phase TMDs on their performance in photoacoustic imaging (PAI) and therapy (PTT) remains unclear. Herein, preparation ultrasmall single-layer nanodots with different phases (1T 2H phase) is reported explore phase-dependent performances as PAI guided PTT second near-infrared (NIR-II) window. Significantly, 1T-MoS2 give a much higher extinction coefficient (25.6 L g-1 cm-1 ) at 1064 nm subsequent power conversion efficiency (PCE: 43.3%) than that 2H-MoS2 (extinction coefficient: 5.3 PCE: 21.3%). Moreover, also strong signals compared negligible NIR-II After modification polyvinylpyrrolidone, can used highly efficient agent effectively ablate cells vitro tumors vivo under laser irradiation. This work proves plays key role determining based TMD nanomaterials PTT.

Language: Английский

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Nanomaterial-based CT contrast agents and their applications in image-guided therapy

Theranostics, Journal Year: 2022, Volume and Issue: 13(2), P. 483 - 509

Published: Dec. 19, 2022

Computed tomography (CT), a diagnostic tool with clinical application, comprehensive coverage, and low cost, is used in hospitals worldwide. However, CT imaging fails to distinguish soft tissues from normal organs tumors because their mass attenuation coefficients are similar. Various contrast agents have been developed recent years improve the sensitivity of imaging. Here, we review progress nanomaterial-based applications image-guided therapy. The classified according components; gold (Au)-based, bismuth (Bi)-based, lanthanide (Ln)-based, transition metal (TM)-based nanomaterials discussed. therapy diseases, including photothermal (PPT), photodynamic (PDT), chemotherapy, radiotherapy (RT), gas therapy, sonodynamic (SDT), immunotherapy, starvation gene (GT), microwave thermal (MWTT), reviewed. Finally, perspectives on biomedical

Language: Английский

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Aggregation‐Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare

Advanced Healthcare Materials, Journal Year: 2018, Volume and Issue: 7(20)

Published: July 3, 2018

Abstract The rapid development of healthcare techniques encourages the emergence new molecular imaging agents and modalities. Fluorescence that enables precise monitoring detection biological processes/diseases is extensively investigated as this technique has strengths in terms high sensitivity, excellent temporal resolution, low cost, good safety. Aggregation‐induced emission luminogens (AIEgens) have recently emerged a class emitters possess several notable features, such brightness, large Stokes shift, marked photostability, biocompatibility, so on. So far, AIEgens are widely explored exhibit superb performance area biomedicine life sciences. Herein, review summarizes discusses recent investigations for vivo diagnosis therapy including long‐term tracking, 3D angiography, multimodality imaging, disease theranostics, activatable sensing. Collectively, these results reveal great promise biomedical applications. It hoped will lead to insights into advanced materials.

Language: Английский

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Oxygen-supplementing mesoporous polydopamine nanosponges with WS2 QDs-embedded for CT/MSOT/MR imaging and thermoradiotherapy of hypoxic cancer

Biomaterials, Journal Year: 2019, Volume and Issue: 220, P. 119405 - 119405

Published: Aug. 4, 2019

Language: Английский

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Bimetallic nanodots for tri-modal CT/MRI/PA imaging and hypoxia-resistant thermoradiotherapy in the NIR-II biological windows

Biomaterials, Journal Year: 2019, Volume and Issue: 233, P. 119656 - 119656

Published: Dec. 2, 2019

Language: Английский

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Multifunctional two-dimensional nanocomposites for photothermal-based combined cancer therapy

Nanoscale, Journal Year: 2019, Volume and Issue: 11(34), P. 15685 - 15708

Published: Jan. 1, 2019

Two-dimensional (2D) nanocomposites have been widely used in biomedical applications during the past few years due to their extraordinary physicochemical properties, which has proved importance field of nanomedicine. Benefiting from excellent optical absorption near-infrared window and large specific surface area, many efforts devoted fabricating 2D nanomaterial-based multifunctional nanoplatforms realize photothermal therapy (PTT)-based or chemotherapy-based synergistic treatment, exhibits obvious anti-tumor effects significantly enhances therapeutic efficiency cancer compared with monotherapy. In particular, are usually fabricated as intelligent for stimuli-responsive nanocarriers, whose could be specifically activated by tumor microenvironment (TME). addition, different fluorescent probes functional inorganic nanomaterials absorbed on fabricate hybrid satisfactory magnetic, optical, other properties that multimodal imaging-guided therapy. this review, latest development combination is systematically summarized, mainly focusing PTT-based therapy, forms potential also simply summarized. Furthermore, design principles particularly emphasized, current challenges future prospects theranostics discussed simultaneously.

Language: Английский

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Transition Metal Dichalcogenides for Sensing and Oncotherapy: Status, Challenges, and Perspective

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 31(5)

Published: Oct. 8, 2020

Abstract Transition metal dichalcogenides (TMDCs) are increasingly being used for chemical sensing, biosensing, and tumor therapy on account of their diversity, biocompatibility, multifunctionality, adjustable bandgap, excellent photoelectric characteristics. This review mainly discusses the effect elemental composition structure TMDCs performance electrochemical, biofluorescence, colorimetric biosensors. The applications in therapies reviewed here. Furthermore, current challenges future directions developing TMDC‐based theranostics summarized.

Language: Английский

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