Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8762 - 8789

Published: Jan. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Language: Английский

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Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 100946 - 100946

Published: Aug. 13, 2020

Language: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

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Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

Advanced Science, Journal Year: 2021, Volume and Issue: 8(10)

Published: March 12, 2021

As a novel noninvasive therapeutic modality combining low-intensity ultrasound and sonosensitizers, sonodynamic therapy (SDT) is promising for clinical translation due to its high tissue-penetrating capability treat deeper lesions intractable by photodynamic (PDT), which suffers from the major limitation of low tissue penetration depth light. The effectiveness feasibility SDT are regarded rely on not only development stable flexible apparatus, but also screening sonosensitizers with good specificity safety. To give an outlook equipment, key technologies discussed according five aspects including ultrasonic dose settings, sonosensitizer screening, tumor positioning, temperature monitoring, reactive oxygen species (ROS) detection. In addition, some state-of-the-art multifunctional equipment integrating diagnosis treatment accurate introduced. Further, overview provided small molecular sensitizers nano/microenhanced sensitizers. Several types nanomaterial-augmented in discussion, porphyrin-based nanomaterials, porphyrin-like inorganic organic-inorganic hybrid nanomaterials different strategies improve efficacy. There no doubt that rapid will be promoted advanced smart nanomaterial-based sonosensitizer, multidisciplinary collaboration.

Language: Английский

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MoS2-based nanocomposites for cancer diagnosis and therapy

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(11), P. 4209 - 4242

Published: April 27, 2021

Molybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used biomedical research. Especially, MoS2-nanomaterials attracted more attention cancer diagnosis treatment recently because their unique physical chemical properties. MoS2 can adsorb various biomolecules drug molecules via covalent or non-covalent interactions it easy to modify possess high specific surface area, improving its tumor targeting colloidal stability, well accuracy sensitivity detecting biomarkers. At same time, near-infrared (NIR) window, has excellent optical absorption prominent photothermal conversion efficiency, which achieve NIR-based phototherapy NIR-responsive controlled drug-release. Significantly, modified MoS2-nanocomposite specifically respond microenvironment, leading accumulation site increased, reducing side effects on non-cancerous tissues, improved therapeutic effect. In this review, we introduced latest developments MoS2-nanocomposites therapy, mainly focusing biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, combination therapy. Furthermore, also discuss current challenges prospects treatment.

Language: Английский

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Biomedical Applications of MXene‐Integrated Composites: Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(34)

Published: June 24, 2022

Abstract MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical biological properties, gained much attention in the biomedical field recent years, including drug delivery systems, regenerative medicine, biosensing. Additionally, incorporation into hydrogels has garnered significant interest engineering an electroactive mechanical nanoreinforcer capable converting nonconductive scaffolds excellent conductors electricity with impressive effect on properties for organs tissues such cardiac, skeletal muscle, nerve. However, many questions problems remain unresolved that need be answered usher these materials toward true destiny. Thus, this review paper aims provide overview design applications MXene‐integrated composites applications, cardiac tissue engineering, wound healing, infection therapy, cancer biosensors. Moreover, current challenges limitations utilizing vivo are highlighted discussed, followed by its prospects guideline possible various futuristic applications. This article will inspire researchers, who search opportunities, using nanomaterial

Language: Английский

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Recent Progress on NIR-II Photothermal Therapy

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: July 29, 2021

Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials near-infrared region (NIR-I, 750-900 nm) attracts extensive attention recent years because good biological penetration NIR light. However, depth still not enough for solid tumors due to high tissue scattering. light second (NIR-II, 1000-1700 allows deeper penetration, higher upper limit radiation and greater tolerance than that NIR-I, it shows application potential conversion. This review summarizes properties Au nanomaterials, two-dimensional materials, metal oxide sulfides polymers NIR-II their prospects It will arouse interest scientists as well nanomedicine.

Language: Английский

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Recent advances in the photothermal applications of two-dimensional nanomaterials: photothermal therapy and beyond

Journal of Materials Chemistry A, Journal Year: 2021, Volume and Issue: 9(33), P. 17569 - 17591

Published: Jan. 1, 2021

The photothermal applications of 2D nanomaterials in therapy, water evaporation, thermochemical reactions, light-driven actuators, electrodes, energy storage, wearable heaters and bacterial inhibition.

Language: Английский

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Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy

Advanced Science, Journal Year: 2021, Volume and Issue: 8(5)

Published: Jan. 15, 2021

Abstract Cancer has been one of the major threats to lives human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order improve treatment efficiency drugs, an intelligent drug delivery system (DDS) considered a promising solution strategy. Due their special structure and large specific surface area, 2D materials are be good platform delivery. Black phosphorus (BP), new star family, recommended have potential construct DDS by virtue its outstanding photothermal (PTT), photodynamic (PDT), biodegradable properties. This tutorial review intended provide introduction current advances BP‐based DDSs cancer therapy, which covers topics from construction, classified types platforms, stimuli‐responsive controlled release. Moreover, applications including mono‐, bi‐, multi‐modal synergistic well research biocompatibility also discussed. Finally, status future prospects summarized.

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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