Magnetic Fluorescent Quantum Dots Nanocomposites in Food Contaminants Analysis: Current Challenges and Opportunities DOI Open Access
Jincheng Xiong, Huixia Zhang,

Linqian Qin

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4088 - 4088

Published: April 7, 2022

The presence of food contaminants can cause foodborne illnesses, posing a severe threat to human health. Therefore, rapid, sensitive, and convenient method for monitoring is eagerly needed. complex matrix interferences samples poor performance existing sensing probes bring significant challenges improving detection performances. Nanocomposites with multifunctional features provide solution these problems. combination the superior characteristics magnetic nanoparticles (MNPs) quantum dots (QDs) fabricate fluorescent (MNPs@QDs) nanocomposites are regarded as an ideal probe analysis. high-efficiency pretreatment rapid fluorescence concurrently integrated into one platform using MNPs@QDs nanocomposites. In this review, contemporary synthetic strategies MNPs@QDs, including hetero-crystalline growth, template embedding, layer-by-layer assembly, microemulsion technique, one-pot method, described in detail, their advantages limitations discussed. recent advances detecting metal ions, pathogens, toxins, pesticides, antibiotics, illegal additives comprehensively introduced from perspectives modes review ends current opportunities practical applications prospects analysis, aiming promote enthusiasm research.

Language: Английский

Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections DOI

Jingjing Huo,

Qingyan Jia, Han Huang

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8762 - 8789

Published: Jan. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Language: Английский

Citations

575

Recent progress of chemodynamic therapy-induced combination cancer therapy DOI
Xianwen Wang,

Xianyan Zhong,

Zhuang Liu

et al.

Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 100946 - 100946

Published: Aug. 13, 2020

Language: Английский

Citations

568

Inorganic nanomaterials with rapid clearance for biomedical applications DOI
Xianwen Wang, Xiaoyan Zhong, Jianxiang Li

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

Citations

367

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers DOI
Zhuoran Gong, Zhifei Dai

Advanced Science, Journal Year: 2021, Volume and Issue: 8(10)

Published: March 12, 2021

As a novel noninvasive therapeutic modality combining low-intensity ultrasound and sonosensitizers, sonodynamic therapy (SDT) is promising for clinical translation due to its high tissue-penetrating capability treat deeper lesions intractable by photodynamic (PDT), which suffers from the major limitation of low tissue penetration depth light. The effectiveness feasibility SDT are regarded rely on not only development stable flexible apparatus, but also screening sonosensitizers with good specificity safety. To give an outlook equipment, key technologies discussed according five aspects including ultrasonic dose settings, sonosensitizer screening, tumor positioning, temperature monitoring, reactive oxygen species (ROS) detection. In addition, some state-of-the-art multifunctional equipment integrating diagnosis treatment accurate introduced. Further, overview provided small molecular sensitizers nano/microenhanced sensitizers. Several types nanomaterial-augmented in discussion, porphyrin-based nanomaterials, porphyrin-like inorganic organic-inorganic hybrid nanomaterials different strategies improve efficacy. There no doubt that rapid will be promoted advanced smart nanomaterial-based sonosensitizer, multidisciplinary collaboration.

Language: Английский

Citations

218

MoS2-based nanocomposites for cancer diagnosis and therapy DOI Creative Commons

Jian-Ling Wang,

Sui Li-hua,

Jia Huang

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(11), P. 4209 - 4242

Published: April 27, 2021

Molybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used biomedical research. Especially, MoS2-nanomaterials attracted more attention cancer diagnosis treatment recently because their unique physical chemical properties. MoS2 can adsorb various biomolecules drug molecules via covalent or non-covalent interactions it easy to modify possess high specific surface area, improving its tumor targeting colloidal stability, well accuracy sensitivity detecting biomarkers. At same time, near-infrared (NIR) window, has excellent optical absorption prominent photothermal conversion efficiency, which achieve NIR-based phototherapy NIR-responsive controlled drug-release. Significantly, modified MoS2-nanocomposite specifically respond microenvironment, leading accumulation site increased, reducing side effects on non-cancerous tissues, improved therapeutic effect. In this review, we introduced latest developments MoS2-nanocomposites therapy, mainly focusing biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, combination therapy. Furthermore, also discuss current challenges prospects treatment.

Language: Английский

Citations

182

Biomedical Applications of MXene‐Integrated Composites: Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing DOI Creative Commons
Aziz Maleki, Matineh Ghomi, Nasser Nikfarjam

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(34)

Published: June 24, 2022

Abstract MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical biological properties, gained much attention in the biomedical field recent years, including drug delivery systems, regenerative medicine, biosensing. Additionally, incorporation into hydrogels has garnered significant interest engineering an electroactive mechanical nanoreinforcer capable converting nonconductive scaffolds excellent conductors electricity with impressive effect on properties for organs tissues such cardiac, skeletal muscle, nerve. However, many questions problems remain unresolved that need be answered usher these materials toward true destiny. Thus, this review paper aims provide overview design applications MXene‐integrated composites applications, cardiac tissue engineering, wound healing, infection therapy, cancer biosensors. Moreover, current challenges limitations utilizing vivo are highlighted discussed, followed by its prospects guideline possible various futuristic applications. This article will inspire researchers, who search opportunities, using nanomaterial

Language: Английский

Citations

143

Recent Progress on NIR-II Photothermal Therapy DOI Creative Commons

Yunguang Zhang,

Siyu Zhang, Zihan Zhang

et al.

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: July 29, 2021

Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials near-infrared region (NIR-I, 750-900 nm) attracts extensive attention recent years because good biological penetration NIR light. However, depth still not enough for solid tumors due to high tissue scattering. light second (NIR-II, 1000-1700 allows deeper penetration, higher upper limit radiation and greater tolerance than that NIR-I, it shows application potential conversion. This review summarizes properties Au nanomaterials, two-dimensional materials, metal oxide sulfides polymers NIR-II their prospects It will arouse interest scientists as well nanomedicine.

Language: Английский

Citations

123

Recent advances in the photothermal applications of two-dimensional nanomaterials: photothermal therapy and beyond DOI
Hui Ma, Mianqi Xue

Journal of Materials Chemistry A, Journal Year: 2021, Volume and Issue: 9(33), P. 17569 - 17591

Published: Jan. 1, 2021

The photothermal applications of 2D nanomaterials in therapy, water evaporation, thermochemical reactions, light-driven actuators, electrodes, energy storage, wearable heaters and bacterial inhibition.

Language: Английский

Citations

122

Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy DOI Creative Commons
Wenxin Liu, Alideertu Dong, Bing Wang

et al.

Advanced Science, Journal Year: 2021, Volume and Issue: 8(5)

Published: Jan. 15, 2021

Abstract Cancer has been one of the major threats to lives human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order improve treatment efficiency drugs, an intelligent drug delivery system (DDS) considered a promising solution strategy. Due their special structure and large specific surface area, 2D materials are be good platform delivery. Black phosphorus (BP), new star family, recommended have potential construct DDS by virtue its outstanding photothermal (PTT), photodynamic (PDT), biodegradable properties. This tutorial review intended provide introduction current advances BP‐based DDSs cancer therapy, which covers topics from construction, classified types platforms, stimuli‐responsive controlled release. Moreover, applications including mono‐, bi‐, multi‐modal synergistic well research biocompatibility also discussed. Finally, status future prospects summarized.

Language: Английский

Citations

116

Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors DOI
Li Zhang, Yue Liu, Haiyan Huang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

Citations

108