Journal of Medicinal Chemistry,
Journal Year:
2022,
Volume and Issue:
65(6), P. 5057 - 5071
Published: Feb. 17, 2022
The
catalytic
properties
of
proteolysis
targeting
chimeras
(PROTACs)
may
lead
to
uncontrolled
off-tissue
target
degradation
that
causes
potential
toxicity,
limiting
their
clinical
applications.
precise
control
this
technology
in
a
tissue-selective
manner
can
minimize
the
toxicity.
Hypoxia
is
hallmark
most
solid
tumors,
accompanied
by
elevated
levels
nitroreductase
(NTR).
Based
on
character,
we
presented
type
NTR-responsive
PROTACs
selectively
degrade
proteins
interest
(POI)
tumor
tissues.
Compound
17-1
was
first
PROTAC
synthesized
incorporating
caging
group
Von
Hippel–Lindau
(VHL)
E3
ubiquitin
ligase
ligand.
It
could
be
activated
NTR
release
active
17
efficiently
EGFR
protein
and
subsequently
exert
antitumor
efficacy.
Thus,
general
strategy
for
induce
POI
tissues
established,
which
provided
generalizable
platform
development
NTR-controlled
achieve
selective
degradation.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(19), P. 5905 - 5905
Published: Sept. 29, 2021
The
drug
delivery
system
enables
the
release
of
active
pharmaceutical
ingredient
to
achieve
a
desired
therapeutic
response.
Conventional
systems
(tablets,
capsules,
syrups,
ointments,
etc.)
suffer
from
poor
bioavailability
and
fluctuations
in
plasma
level
are
unable
sustained
release.
Without
an
efficient
mechanism,
whole
process
can
be
rendered
useless.
Moreover,
has
delivered
at
specified
controlled
rate
target
site
as
precisely
possible
maximum
efficacy
safety.
Controlled
developed
combat
problems
associated
with
conventional
delivery.
There
been
tremendous
evolution
past
two
decades
ranging
macro
scale
nano
intelligent
targeted
initial
part
this
review
provides
basic
understanding
emphasis
on
pharmacokinetics
drug.
It
also
discusses
their
limitations.
Further,
discussed
detail
design
considerations,
classifications
drawings.
In
addition,
nano-drug
delivery,
smart
using
stimuli-responsive
biomaterials
is
recent
key
findings.
paper
concludes
challenges
faced
future
directions
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
120(24), P. 13135 - 13272
Published: Oct. 30, 2020
Photoactivatable
(alternatively,
photoremovable,
photoreleasable,
or
photocleavable)
protecting
groups
(PPGs),
also
known
as
caged
photocaged
compounds,
are
used
to
enable
non-invasive
spatiotemporal
photochemical
control
over
the
release
of
species
interest.
Recent
years
have
seen
development
PPGs
activatable
by
biologically
and
chemically
benign
visible
near-infrared
(NIR)
light.
These
long-wavelength-absorbing
moieties
expand
applicability
this
powerful
method
its
accessibility
non-specialist
users.
This
review
comprehensively
covers
organic
transition
metal-containing
photoactivatable
compounds
(complexes)
that
absorb
in
visible-
NIR-range
various
leaving
gasotransmitters
(carbon
monoxide,
nitric
oxide,
hydrogen
sulfide).
The
text
NIR-light-induced
photosensitized
using
molecular
sensitizers,
quantum
dots,
upconversion
second-harmonic
nanoparticles,
well
via
photodynamic
(photooxygenation
singlet
oxygen)
photothermal
effects.
Release
from
polymers,
micelles,
vesicles,
photoswitches,
along
with
related
emerging
field
photopharmacology,
is
discussed
at
end
review.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(14)
Published: Feb. 24, 2021
Abstract
Infrared
(IR)
adaptation
phenomena
are
ubiquitous
in
nature
and
biological
systems.
Taking
inspiration
from
natural
creatures,
researchers
have
devoted
extensive
efforts
for
developing
advanced
IR
adaptive
materials
exploring
their
applications
areas
of
smart
camouflage,
thermal
energy
management,
biomedical
science,
many
other
IR‐related
technological
fields.
Herein,
an
up‐to‐date
review
is
provided
on
the
recent
advancements
bioinspired
promising
applications.
First
overview
artificial
technologies
presented.
Recent
endeavors
then
introduced
toward
camouflage
radiative
cooling.
According
to
Stefan‐Boltzmann
law,
can
be
realized
by
either
emissivity
engineering
or
cloaks.
cooling
maximize
radiation
object
through
atmospheric
transparency
window,
thus
holds
great
potential
use
energy‐efficient
green
buildings
personal
management
advances
emerging
near‐IR
(NIR)
also
discussed,
including
NIR‐triggered
technologies,
NIR
light‐fueled
soft
robotics,
light‐driven
supramolecular
nanosystems.
This
concludes
with
a
perspective
challenges
opportunities
future
development
materials.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(34)
Published: July 15, 2020
Therapeutic
systems
with
site-specific
pharmaceutical
activation
hold
great
promise
to
enhance
therapeutic
efficacy
while
reducing
systemic
toxicity
in
cancer
therapy.
With
operational
flexibility,
noninvasiveness,
and
high
spatiotemporal
resolution,
photoactivatable
nanomedicines
have
drawn
growing
attention.
Distinct
from
traditional
controlled
release
relying
on
the
difference
of
biomarker
concentrations
between
disease
healthy
tissues,
capitalize
interaction
nanotransducers
light
either
trigger
photochemical
reactions
or
generate
reactive
oxygen
species
(ROS)
heat
effect
remotely
induce
actions
living
subjects.
Herein,
recent
advances
development
protherapeutic
nanoagents
for
oncology
are
summarized.
The
design
strategies
applications
these
described.
Representative
examples
each
type
discussed
terms
structure,
photoactivation
mechanism,
preclinical
models.
Last,
potential
challenges
perspectives
further
develop
nanomedicine
discussed.
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(19), P. 7380 - 7387
Published: May 10, 2021
PROTACs
(proteolysis
targeting
chimeras)
are
an
emerging
class
of
promising
therapeutic
modalities
that
degrade
intracellular
protein
targets
by
hijacking
the
cellular
ubiquitin–proteasome
system.
However,
potential
toxicity
in
normal
cells
due
to
off-tissue
on-target
degradation
effect
limits
their
clinical
applications.
Precise
control
a
PROTAC's
activity
tissue-selective
manner
could
minimize
toxicity/side-effects.
To
this
end,
we
developed
cancer
cell
selective
delivery
strategy
for
conjugating
folate
group
ligand
VHL
E3
ubiquitin
ligase,
achieve
targeted
proteins
interest
(POIs)
versus
noncancerous
cells.
We
show
our
folate-PROTACs,
including
BRD
PROTAC
(folate-ARV-771),
MEK
(folate-MS432),
and
ALK
(folate-MS99),
capable
degrading
BRDs,
MEKs,
ALK,
respectively,
receptor-dependent
This
design
provides
generalizable
platform
POIs
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(13)
Published: Feb. 27, 2022
Infections
are
regarded
as
the
most
severe
complication
associated
with
human
health,
which
urgent
to
be
solved.
Stimuli-responsive
materials
appealing
therapeutic
platforms
for
antibacterial
treatments,
provide
great
potential
accurate
theranostics.
In
this
review,
advantages,
response
mechanisms,
and
key
design
principles
of
stimuli-responsive
highlighted.
The
biomedical
applications,
current
challenges,
future
directions
also
discussed.
First,
categories
comprehensively
itemized
based
on
different
sources
stimuli,
including
external
physical
environmental
stimuli
(e.g.,
temperature,
light,
electricity,
salt,
etc.)
bacterial
metabolites
acid,
enzyme,
redox,
etc.).
Second,
structural
characteristics,
principles,
applications
responsive
discussed,
underlying
interrelationships
revealed.
molecular
structures
closely
related
stimuli.
Finally,
challenging
issues
proposed.
This
review
will
scientific
guidance
promote
clinical
materials.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
17, P. 29 - 48
Published: Jan. 19, 2022
Biotherapy
has
recently
become
a
hotspot
research
topic
with
encouraging
prospects
in
various
fields
due
to
wide
range
of
treatments
applications,
as
demonstrated
preclinical
and
clinical
studies.
However,
the
broad
applications
biotherapy
have
been
limited
by
critical
challenges,
including
lack
safe
efficient
delivery
systems
serious
side
effects.
Due
unique
potentials
biomaterials,
such
good
biocompatibility
bioactive
properties,
biomaterial-assisted
be
an
attractive
strategy.
The
biomaterial-based
possess
sufficient
packaging
capacity
versatile
functions,
enabling
sustained
localized
release
drugs
at
target
sites.
Furthermore,
biomaterials
can
provide
niche
specific
extracellular
conditions
for
proliferation,
differentiation,
attachment,
migration
stem
cells,
leading
tissue
regeneration.
In
this
review,
state-of-the-art
studies
on
biotherapy,
drug
delivery,
vaccine
development,
gene
therapy,
cell
summarized.
challenges
outlook
biotherapies
also
discussed.
