Ligand Chemistry in Antitumor Theranostic Nanoparticles

Accounts of Chemical Research, Journal Year: 2023, Volume and Issue: 56(12), P. 1578 - 1590

Published: May 23, 2023

ConspectusTheranostic nanoparticles' potential in tumor treatment has been widely acknowledged thanks to their capability of integrating multifaceted functionalities into a single nanosystem. Theranostic nanoparticles are typically equipped with an inorganic core exploitable physical properties for imaging and therapeutic functions, bioinert coatings improved biocompatibility immunological stealth, controlled drug-loading–release modules, the ability recognize specific cell type uptake. Integrating multiple nanosized construct require sophisticated molecular design precise execution assembly procedures. Underlying multifunctionality theranostic nanoparticles, ligand chemistry plays decisive role translating theoretical designs fully functionalized nanoparticles. The hierarchy is usually threefold. As they serve passivate nanoparticle's surface, capping ligands form first layer directly interfacing crystalline lattice core. size shape largely determined by property so that have profound influences on surface properties. Capping mostly chemically inert, which necessitates presence additional drug loading targeting. second commonly utilized loading. Therapeutic drugs can either be covalently conjugated onto or noncovalently loaded via drug-loading ligands. Drug-loading need equally versatile accommodate diversity drugs. Biodegradable moieties often incorporated enable smart release. With aid targeting stand tallest nanoparticle seek bind corresponding receptors target, preferentially accumulate at site attain higher precision quantity delivery. In this Account, utilities representative ligands, reviewed. Since these types assembled close vicinity each other, it essential them compatible able function tandem other. Relevant conjugation strategies critical factors significant impact ligands' performance discussed. Representative presented showcase how different synergistically from Finally, technological outlook evolving provided.

Language: Английский

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Biomaterial-based platforms for modulating immune components against cancer and cancer stem cells

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 161, P. 1 - 36

Published: March 10, 2023

Language: Английский

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Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 374, P. 219 - 229

Published: Aug. 16, 2024

Nanoparticles (NPs) can be designed for targeted delivery in cancer nanomedicine, but the challenge is a low efficiency (DE) to tumor site. Understanding impact of NPs' physicochemical properties on target tissue distribution and DE help improve design nanomedicines. Multiple machine learning artificial intelligence models, including linear regression, support vector machine, random forest, gradient boosting, deep neural networks (DNN), were trained validated predict based therapeutic strategies with dataset from Nano-Tumor Database. Compared other DNN model had superior predictions tumors major tissues. The determination coefficients (R

Language: Английский

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Phase-separating Pt(IV)-graft-glycopeptides sequentially sensing pH and redox for deep tumor penetration and targeting chemotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 743 - 756

Published: Jan. 25, 2025

Language: Английский

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Disulfide-Cross-Linked Nanogel-Based Nanoassemblies for Chemotherapeutic Drug Delivery

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(21), P. 25324 - 25338

Published: May 16, 2023

Although nanoparticle-based chemotherapeutic strategies have gained in popularity, the efficacy of such therapies is still limited part due to different nanoparticle sizes needed best accommodate parts drug delivery pathway. Herein, we describe a nanogel-based nanoassembly based on entrapment ultrasmall starch nanoparticles (size 10–40 nm) within disulfide-crosslinked chondroitin sulfate-based nanogels 150–250 address this challenge. Upon exposure reductive tumor microenvironment, nanogel can degrade release doxorubicin-loaded facilitate improved intratumoral penetration. CT26 colon carcinoma spheroids could be efficiently penetrated by (resulting 1 order magnitude higher DOX-derived fluorescence inside spheroid relative free DOX), while vivo experiments showed that nanoassemblies reduced 6× saline controls and 2× DOX after 21 days. Together, these data suggest are viable option for improving safety vehicles treating cancer.

Language: Английский

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In Vivo NIR‐II Fluorescence Lifetime Imaging of Whole‐Body Vascular Using High Quantum Yield Lanthanide‐Doped Nanoparticles

Small, Journal Year: 2023, Volume and Issue: 19(35)

Published: May 1, 2023

Second near infrared (NIR-II, 1000-1700 nm) fluorescence lifetime imaging is a powerful tool for biosensing, anti-counterfeiting, and multiplex imaging. However, the low photoluminescence quantum yield (PLQY) of probes in NIR-II region limits its data collecting efficiency accuracy, especially molecular vivo. To solve this problem, lanthanide-doped nanoparticles (NPs) β-NaErF4 : 2%Ce@NaYbF4 @NaYF4 with high PLQY tunable PL through multi-ion doping core-shell structural design, are presented. The obtained internal can reach up to 50.1% cyclohexane 9.2% water under excitation at 980 nm. Inspired by above results, fast whole-body vascular mice successfully performed using homebuilt system, which reveals murine abdominal capillary network background. A further demonstration carried out atherosclerosis cells different organs vivo NPs conjugating specific peptides injection modalities, respectively. These results demonstrate that combined system realize signal-to-noise imaging; thus, opening road atherosclerosis.

Language: Английский

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Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(6), P. 290 - 290

Published: May 24, 2023

Bioactive nanomaterials are increasingly being applied in oral health research. Specifically, they have shown great potential for periodontal tissue regeneration and substantially improved translational clinical applications. However, their limitations side effects still need to be explored elucidated. This article aims review the recent advancements discuss future research directions this field, especially focusing on using improve health. The biomimetic physiochemical properties of such as metals polymer composites described detail, including alveolar bone, ligament, cementum gingiva. Finally, biomedical safety issues application regenerative materials updated, with a discussion about complications perspectives. Although applications bioactive cavity at an initial stage, pose numerous challenges, suggests that promising alternative regeneration.

Language: Английский

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Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 9, 2024

Abstract Background Active targeting by surface-modified nanoplatforms enables a more precise and elevated accumulation of nanoparticles within the tumor, thereby enhancing drug delivery efficacy for successful cancer treatment. However, surface functionalization involves complex procedures that increase costs timelines, presenting challenges clinical implementation. Biomimetic (BNPs) have emerged as unique platforms overcome limitations actively targeted nanoparticles. Nevertheless, BNPs coated with unmodified cells show reduced functionalities such specific tumor targeting, decreasing therapeutic efficacy. Those can be engineering non-patient-derived BNP coating, but these are cost-effective approaches hinder their wider application. Here we present an immune-driven strategy to improve nanotherapeutic tumors. Our perspective harnesses T-cell exhaustion immune evasion develop groundbreaking new class crafted from exhausted T-cells (NExT) triple-negative breast (TNBC) patients culture methods without sophisticated engineering. Methods NExT were generated coating PLGA (poly(lactic-co-glycolic acid)) TNBC-derived in vitro acute activation. Physicochemical characterization was made dynamic light scattering, electrophoretic scattering transmission electron microscopy, preservation orientation checkpoint receptors flow cytometry. The chemotherapy-loaded assessed TNBC cell lines vitro. In vivo toxicity CD1 mice. Biodistribution activity determined cell-line- autologous patient-derived xenografts immunodeficient Results We report approach good performance provides naturally endowed (PD1, LAG3, TIM3), augmenting engaging cognate ligands, chemotherapy, disrupting PD1/PDL1 axis immunotherapy-like way. Autologous revealed exceptional intratumor accumulation, heightened chemotherapeutic index efficiency, stroma PDL1 + xenograft model cancer. Conclusions These advantages underline potential revolutionize tailored adoptive nanotherapy chemoimmunotherapy, which endorses widespread application NExT.

Language: Английский

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An aminopeptidase N-activatable chemiluminescence probe for image-guided surgery and metastasis tracking of tumor

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 208, P. 114212 - 114212

Published: March 31, 2022

Language: Английский

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Dual size/charge-switchable and multi-responsive gelatin-based nanocluster for targeted anti-tumor therapy

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 238, P. 124032 - 124032

Published: March 14, 2023

Language: Английский

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