AIChE Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 22, 2024
Abstract
Due
to
the
unique
drug
delivery
mode
and
specific
therapy,
nano‐formulations
are
of
interest
for
biomedical
applications
treating
many
diseases.
However,
traditional
method
nano‐formulation
construction
via
additional
carriers
or
structural
modifications
therapeutic
drugs
might
be
cumbersome
low
loading‐efficient.
Herein,
kinetics,
accessible
pathways,
final
outcomes
supramolecular
assembly
processes
investigated
in
detail.
It
was
found
that
aggregates
cephradine
(CEP)
undergoes
a
morphological
transformation
from
anisotropic
nanofiber
(EtOH)
isotropic
spherical
nanoparticle
(H
2
O),
similar
“plants
took
root,
sprouted,
blossomed
bore
fruit.”
Moreover,
kinetics
results
reveal
pathways
nucleation
elongation
H
O
surface‐catalyzed
secondary
EtOH.
The
presented
this
work
has
potential
used
efficiently
designing
nano‐formulations.
Gels,
Journal Year:
2023,
Volume and Issue:
9(7), P. 523 - 523
Published: June 27, 2023
Polymer-based
hydrogels
are
hydrophilic
polymer
networks
with
crosslinks
widely
applied
for
drug
delivery
applications
because
of
their
ability
to
hold
large
amounts
water
and
biological
fluids
control
release
based
on
unique
physicochemical
properties
biocompatibility.
Current
trends
in
the
development
hydrogel
systems
involve
drugs
response
specific
triggers
such
as
pH,
temperature,
or
enzymes
targeted
reduce
potential
systemic
toxicity.
In
addition,
developing
injectable
formulations
that
easily
used
sustain
during
this
extended
time
is
a
growing
interest.
Another
emerging
trend
synthesis
nano
other
functional
substances
improving
loading
efficacy.
Following
these
trends,
advanced
possessing
mechanically
improved
properties,
controlled
rates,
biocompatibility
focus
field.
More
complex
multi-drug
combination
therapies
will
be
developed
advancements.
polymer-based
gaining
increasing
attention
personalized
medicine
tailored
patient,
example,
combinations,
target-specific
delivery,
improvement
disease
treatment
effectiveness,
healthcare
cost
reduction.
Overall,
application
advancing
rapidly,
towards
more
efficient
effective
future.
Journal of Applied Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
ABSTRACT
Chitosan
(CS)‐based
drug
delivery
systems
often
face
challenges
in
obtaining
clinical
approval.
Enhancing
the
binding
affinity
of
CS‐based
carriers
to
target
cells,
such
as
tumor
is
crucial
for
their
translation
from
bench
bedside.
Strategies
like
crosslinking
(NHS‐disulfide‐NHS)
and
utilizing
materials
albumin
have
proven
effective
strengthening
interactions
between
nanoparticles
thereby
enhancing
cellular
uptake
(cellular
avidity).
This
study
presents
a
novel
approach
using
crosslinked
CS
loaded
with
doxorubicin,
featuring
reduction‐responsive
release
coating.
The
albumin‐coated
chitosan
(ACCC)
was
assembled
via
reaction
amino
CS/albumin
NHS‐disulfide‐NHS.
resulting
ACCC
nanoparticle
micelles
demonstrate
enhanced
stability
micelles.
hybrid
network
ensures
while
providing
ample
space
loading
achieves
through
disulfide
bond
crosslinking.
Moreover,
proposed
system
possesses
excellent
biocompatibility.
Compared
uncoated
micelles,
exhibit
potent
cytotoxicity
against
particularly
reducing
environment.
Fluorescence
imaging
flow
cytometry
analyses
confirm
conferred
by
These
findings
underscore
potential
improving
cell
adhesion
anti‐tumor
efficacy,
thus
offering
promising
prospects
translational
medicine
delivery.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
495, P. 153522 - 153522
Published: June 26, 2024
Most
electrochemical
biosensors
require
sample
processing
to
reduce
biofouling
induced
by
the
complex
composition
of
biological
samples
that
typically
causes
a
decrease
in
target-to-blank
signal.
Herein,
we
report
zwitterionic
copolymer
bearing
sulfobetaine,
carboxylic,
aldehyde,
and
thiol
groups
as
thin
(∼16
nm)
anti-fouling
coating
for
biosensing
platforms.
The
resulting
polymer-coated
electrodes
reduced
protein
adsorption
∼
67
%
compared
bare-gold
surface
when
incubated
with
radiolabeled
human
serum
albumin
(HSA)
protein-spiked
plasma,
while
cyclic
voltammetry
yielded
5
increase
anodic
current
signal
after
incubation
1
HSA
h
83
observed
bare
gold
electrodes.
electrode
facilitated
detection
redox-labeled
DNA
buffer,
well
unprocessed
undiluted
plasma
limits
23
nM
21
nM,
respectively;
104
cp
mL−1
lentivirus
pseudotyped
Omicron
spike
SARS-CoV-2
unfiltered
50
saliva
was
also
achieved
within
min
improved
ratios
reproducibility
relative
well-established
PEG-based
platform
detecting
COVID-19.
On
this
basis,
Zwitter-repel
offers
potential
sensitively
detect
other
disease
biomarkers/analytes
eliminating
or
reducing
need
pre-processing
and/or
use
additional
backfilling/blocking
agents.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(23)
Published: Feb. 7, 2024
Abstract
The
integrative
use
of
light
and
nanoassemblies
has
made
a
profound
impact
in
the
biomedical
field
for
diagnosis,
drug
delivery,
phototherapy.
Recent
advances
development
light‐responsive
showcase
their
capabilities
facilitating
targeted
diagnosis
therapy
with
minimal
invasiveness,
shaping
future
personalized
medicine.
In
this
work,
fundamental
differences
between
types
applications,
application
are
described,
biosafety
profile
is
overviewed
discussed,
translational
challenges
potential
clinical
outlook
emerging
outlined.
in
the
context
of
advanced
nanomaterials
research,
nanogels
have
recently
gained
considerable
attention
for
their
versatility
and
promising
biomedical
applications.
To
date,
a
significant
number
been
developed
to
meet
growing
demands
various
fields
research.
Summarising
preparation
methods,
physicochemical
biological
properties
recent
applications
may
be
useful
help
exploring
new
directions
development.
This
article
presents
comprehensive
overview
latest
nanogel
synthesis
methodologies,
highlighting
advances
formulation
with
different
types
hydrophilic
or
amphiphilic
polymers.
It
also
underlines
drug
delivery
imaging,
short
section
dedicated
biosafety
considerations
these
innovative
nanomaterials.
In
conclusion,
this
summarises
innovations
numerous
applications,
potential
field.
Gels,
Journal Year:
2024,
Volume and Issue:
10(7), P. 476 - 476
Published: July 18, 2024
Stroke
remains
the
second
leading
cause
of
death
and
a
major
disability
worldwide,
significantly
impacting
individuals,
families,
healthcare
systems.
This
neurological
emergency
can
be
triggered
by
ischemic
events,
including
small
vessel
arteriolosclerosis,
cardioembolism,
large
artery
atherothromboembolism,
as
well
hemorrhagic
incidents
resulting
from
macrovascular
lesions,
venous
sinus
thrombosis,
or
vascular
malformations,
to
significant
neuronal
damage.
The
resultant
motor
impairment,
cognitive
dysfunction,
emotional
disturbances
underscore
urgent
need
for
effective
therapeutic
interventions.
Recent
advancements
in
biomaterials,
particularly
hydrogels,
offer
promising
new
avenues
stroke
management.
Hydrogels,
composed
three-dimensional
networks
hydrophilic
polymers,
are
notable
their
ability
absorb
retain
substantial
amounts
water.
Commonly
used
polymers
hydrogel
formulations
include
natural
like
alginate,
chitosan,
collagen,
synthetic
such
polyethylene
glycol
(PEG),
polyvinyl
alcohol
(PVA),
polyacrylamide.
Their
customizable
characteristics—such
porosity,
swelling
behavior,
mechanical
strength,
degradation
rates—make
hydrogels
ideal
biomedical
applications,
drug
delivery,
cell
tissue
engineering,
controlled
release
agents.
review
comprehensively
explores
hydrogel-based
approaches
both
therapy,
elucidating
mechanisms
which
provide
neuroprotection.
It
covers
application
delivery
systems,
role
reducing
inflammation
secondary
injury,
potential
support
neurogenesis
angiogenesis.
also
discusses
current
technology
challenges
translating
these
innovations
research
into
clinical
practice.
Additionally,
it
emphasizes
limited
number
trials
utilizing
therapies
addresses
associated
limitations
constraints,
underscoring
further
this
field.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
277, P. 134385 - 134385
Published: Aug. 5, 2024
Intranasal
(IN)
delivery
offers
potential
to
deliver
antipsychotic
drugs
with
improved
efficacy
the
brain.
However,
solubilization
of
such
and
frequency
required
re-application
both
represent
challenges
its
practical
implementation
in
treating
various
mental
illnesses
including
schizophrenia.
Herein,
we
report
a
sprayable
nanoparticle
network
hydrogel
(NNH)
consisting
hydrophobically-modified
starch
nanoparticles
(SNPs)
mucoadhesive
chitosan
oligosaccharide
lactate
(COL)
that
can
gel
situ
within
nasal
cavity
release
ultra-small
penetrative
SNPs
over
time.
Hydrophobization
enables
enhanced
uptake
prolonged
poorly
water
soluble
as
olanzapine
from
NNH
depot
through
mucous
ultimately
into
brain
via
nose-to-brain
(N2B)
pathway.
The
shows
high
vitro
cytocompatibility
mouse
striatal
neuron
human
primary
cell
lines
vivo
an
amphetamine-induced
pre-clinical
rat
schizophrenia
model,
IN-delivered
hydrogels
maintaining
successful
attenuation
locomotor
activity
for
up
4
h
while
all
other
tested
treatments
(drug-only
IN
or
conventional
intraperitoneal
delivery)
failed
attenuate
at
any
time
point
past
0.5
h.
As
such,
situ-gelling
NNHs
safe
excipient
hydrophobic
directly
using
customized
exhibit
penetration
drug
complexing
properties
maximize
effective
delivery.
