Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration

ACS Nano, Journal Year: 2022, Volume and Issue: 17(1), P. 168 - 183

Published: Dec. 16, 2022

The development of therapeutics for effective treatments retinal diseases is significantly constrained by various biological barriers. We herein report a nanomedicine strategy to develop nanotherapeutics featured with not only high permeability but also sustained bioactive delivery. Specifically, the are rationally designed via aminolysis resveratrol-encapsulated polycaprolactone nanoparticles (R@PCL NPs), followed formation amide linkages carboxyl-terminated transacting activator transcription cell penetrating peptide (T) and metformin (M). R@PCL-T/M NP demonstrated in vitro possess persistent drug release profiles, good ocular biocompatibility, potent activities targeting prevailing risk factors associated diseases. In vivo studies indicate that single-dose intravitreal administration NPs can effectively improve (∼15-fold increase), prevent loss endogenous antioxidants, suppress growth abnormal vessels retina macular degeneration 56 days. This treatment efficacy be ascribed enhanced conjunction pharmacological activity dual drugs (R M) pigment epithelial region. These findings show great promise nanoformulations capable thereby treating complex posterior segment improved efficacies.

Language: Английский

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Coupling Probiotics with 2D CoCuMo‐LDH Nanosheets as a Tumor‐Microenvironment‐Responsive Platform for Precise NIR‐II Photodynamic Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 13, 2023

Photodynamic therapy (PDT) has become a promising cancer treatment approach with superior advantages. However, it remains grand challenge to develop tumor microenvironment (TME)-responsive photosensitizers (PSs) for tumor-targeting precise PDT. Herein, the coupling Lactobacillus acidophilus (LA) probiotics 2D CoCuMo layered-double-hydroxide (LDH) nanosheets (LA&LDH) is reported as TME-responsive platform NIR-II The CoCuMo-LDH loaded on LA can be transformed from crystalline into amorphous through etching by LA-metabolite-enabled low pH and overexpressed glutathione. TME-induced in situ amorphization of boost its photodynamic activity singlet oxygen (1 O2 ) generation under 1270 nm laser irradiation relative 1 quantum yield 1.06, which highest among previously NIR-excited PSs. In vitro vivo assays prove that LA&LDH effectively achieve complete cell apoptosis eradication irradiation. This study proves used highly efficient

Language: Английский

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Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine

Theranostics, Journal Year: 2022, Volume and Issue: 12(11), P. 4879 - 4903

Published: Jan. 1, 2022

In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles which are involved in various physiological and pathological processes including cell proliferation, immune regulation, angiogenesis tissue repair, have emerged one of the most attractive nanotherapeutics for regenerative medicine. Herein we provide a systematic review latest progress EVs applications. Firstly, will briefly introduce biogenesis, function isolation technology EVs. Then, underlying therapeutic mechanisms native unmodified engineering strategies modified entities be discussed. Subsequently, main focus placed on repair regeneration applications organs brain, heart, bone cartilage, liver kidney, well skin. More importantly, current clinical trials medicine also highlighted. Finally, future challenges insightful perspectives currently developed EV-based biomedicine short, opened new horizons biologists, chemists, nanoscientists, pharmacists, clinicians, making possible powerful tools therapies

Language: Английский

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Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 25, 2023

Abstract Nanomedicine holds great promise to enhance cancer therapy. However, low active pharmaceutical ingredient (API) loading content, unpredictable drug release, and potential toxicity from excipients limit their translational capability. We herein report a full-API nanodrug composed of FDA-approved 5-aminolevulinic acid (ALA), human essential element Fe 3+ , natural bioactive compound curcumin with an ideal API content pH-responsive release profile for continuous spatiotemporal therapy achieved by multi-step tandem endogenous biosynthesis. First, ALA enzymatically converts into photosensitizer protoporphyrin IX (PpIX). Afterward, multiple downstream products including carbon monoxide (CO), 2+ biliverdin (BV), bilirubin (BR) are individually biosynthesized through the PpIX-heme-CO/Fe /BV-BR metabolic pathway, further cooperating released curcumin, ultimately eliciting mitochondria damage, membrane disruption, intracytoplasmic injury. This work not only provides paradigm exploiting diversified metabolites tumor suppression, but also presents safe efficient nanodrug, facilitating practical translation nanodrugs.

Language: Английский

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Advances and applications of nanoparticles in cancer therapy

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

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Two-photon excitation photosensitizers for photodynamic therapy: From small-molecules to nano-complex systems

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215711 - 215711

Published: Feb. 18, 2024

Language: Английский

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Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Language: Английский

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Recent Advances in Structural Design of Efficient Near‐Infrared Light‐Emitting Organic Small Molecules

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(1)

Published: Oct. 31, 2022

Abstract Organic light‐emitting materials in the near‐infrared (NIR) region are important to realize next‐generation lightweight and wearable applications bioimaging, photodynamic therapy, telecommunications. Inorganic organometallic expensive toxic; thus, development of purely organic is essential. However, highly efficient NIR made still its infancy. Therefore, this review outlines molecular design strategies for developing small‐molecule with high emission efficiency that can overcome energy‐gap law be applied devices. After briefly reviewing basic knowledge required molecules, representative high‐efficiency molecules reported over past 5 years classified according their core moieties, design, physical properties, luminescence characteristics analyzed. Further, perspective outlook regarding provided.

Language: Английский

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Emerging nanotherapeutics for facilitating photodynamic therapy

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 451, P. 138621 - 138621

Published: Aug. 12, 2022

Language: Английский

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Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet–Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(4), P. 5112 - 5121

Published: Jan. 20, 2022

Type-I photodynamic therapy (PDT) with less oxygen consumption shows great potential for overcoming the vicious hypoxia typically observed in solid tumors. However, development of type-I PDT is hindered by insufficient radical generation and ambiguous design strategy photosensitizers (PSs). Therefore, developing highly efficient PSs unveiling their structure-function relationship are still urgent challenging. Herein, we develop two phenanthro[9,10-d]imidazole derivatives (AQPO AQPI) aggregation-induced emission (AIE) characteristics boost reactive species (ROS) efficiency reducing singlet-triplet splitting (ΔEST). Both AQPO AQPI show ultrasmall ΔEST values 0.09 0.12 eV, respectively. By incorporating electron-rich anisole, categories generated ROS AIE changed from type-II (singlet oxygen, 1O2) to (superoxide anion radical, O2•- hydroxyl •OH). We demonstrate that assembled nanoparticles (NPs) achieve a 3.2- 2.9-fold increase •OH efficiencies, respectively, compared those NPs (without anisole) water, whereas 1O2 lower (0.4-fold) than NPs. The small anisole group endow an excellent capacity generation. In vitro vivo experiments hypoxia-overcoming effect efficiently eliminating tumor cells upon white light irradiation good biosafety.

Language: Английский

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