Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 14, 2024
With
the
COVID-19
pandemic,
importance
of
vaccines
has
been
widely
recognized
and
led
to
increased
research
development
efforts.
Vaccines
also
play
a
crucial
role
in
cancer
treatment
by
activating
immune
system
target
destroy
cells.
However,
enhancing
efficacy
remains
challenge.
Adjuvants,
which
enhance
response
antigens
improve
vaccine
effectiveness,
have
faced
limitations
recent
years,
resulting
few
novel
adjuvants
being
identified.
The
advancement
artificial
intelligence
(AI)
technology
drug
provided
foundation
for
adjuvant
screening
application,
leading
diversification
adjuvants.
This
article
reviews
significant
tumor
basic
clinical
explores
use
AI
screen
from
databases.
findings
this
review
offer
valuable
insights
new
next-generation
vaccines.
Small,
Journal Year:
2023,
Volume and Issue:
20(7)
Published: Oct. 6, 2023
Abstract
Photothermal
therapy
(PTT),
which
employs
nanoscale
transducers
delivered
into
a
tumor
to
locally
generate
heat
upon
irradiation
with
near‐infrared
light,
shows
great
potential
in
killing
cancer
cells
through
hyperthermia.
The
efficacy
of
such
treatment
is
determined
by
number
factors,
including
the
amount,
distribution,
and
dissipation
generated
heat,
as
well
type
cell
involved.
amount
largely
controlled
accumulated
inside
tumor,
absorption
coefficient
photothermal
conversion
efficiency
transducer,
irradiance
light.
depends
on
distribution
penetration
depth
vascularity
tissue
thermal
conduction
both
affect
thereby
temperature.
successful
implementation
PTT
clinic
setting
critically
techniques
for
real‐time
monitoring
management
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: April 5, 2024
Abstract
Rapid
advances
in
nanotechnology
have
made
it
possible
to
combine
photothermal
therapy
(PTT)
with
immunotherapy,
enabling
activate
an
situ
vaccine
effect.
However,
this
effect
is
severely
impeded
by
low
antigen
presentation
level
and
highly
suppressive
tumor
immune
microenvironment
(immune
“cold”
tumors).
To
overcome
the
obstacles,
multifunctional
carrier‐free
nanoparticles
(FCDP‐NPs)
assembled
from
Fe
2+
,
toll‐like
receptor
9
agonist
(CpG),
cationic
lipid
(DOTAP)
agent
polydopamine
are
developed.
After
intratumoral
injection,
FCDP‐NPs
carrying
positive
charge
exposed
under
laser
irradiation,
which
can
capture
tumor‐associated
antigens
(TAAs)
generated
upon
post‐PTT
form
nanovaccines
(FCD‐NPs@TAAs).
The
further
promote
cross‐presentation
of
TAAs,
stimulate
adaptive
responses,
shape
“hot”
tumors.
As
a
result,
improve
survival
rates
elicit
durable
memory
that
remarkedly
prevents
metastasis,
illustrating
useful
platform
for
PTT
synergized
immunotherapy.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 30, 2024
Abstract
Every
single
cell
can
communicate
with
other
cells
in
a
paracrine
manner
via
the
production
of
nano-sized
extracellular
vesicles.
This
phenomenon
is
conserved
between
prokaryotic
and
eukaryotic
cells.
In
cells,
exosomes
(Exos)
are
main
inter-cellular
bioshuttles
potential
to
carry
different
signaling
molecules.
Likewise,
bacteria
produce
release
Exo-like
particles,
namely
microvesicles
(MVs)
into
matrix.
Bacterial
MVs
function
diverse
biological
properties
at
center
attention
due
their
inherent
therapeutic
properties.
Here,
this
review
article,
comparable
Exos
bacterial
were
highlighted
terms
biomedical
application.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 14, 2024
With
the
COVID-19
pandemic,
importance
of
vaccines
has
been
widely
recognized
and
led
to
increased
research
development
efforts.
Vaccines
also
play
a
crucial
role
in
cancer
treatment
by
activating
immune
system
target
destroy
cells.
However,
enhancing
efficacy
remains
challenge.
Adjuvants,
which
enhance
response
antigens
improve
vaccine
effectiveness,
have
faced
limitations
recent
years,
resulting
few
novel
adjuvants
being
identified.
The
advancement
artificial
intelligence
(AI)
technology
drug
provided
foundation
for
adjuvant
screening
application,
leading
diversification
adjuvants.
This
article
reviews
significant
tumor
basic
clinical
explores
use
AI
screen
from
databases.
findings
this
review
offer
valuable
insights
new
next-generation
vaccines.
