International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 1443 - 1490
Published: Feb. 1, 2025
Abstract:
Given
the
complexity
of
central
nervous
system
(CNS)
and
diversity
neurological
conditions,
increasing
prevalence
disorders
poses
a
significant
challenge
to
modern
medicine.
These
disorders,
ranging
from
neurodegenerative
diseases
psychiatric
not
only
impact
individuals
but
also
place
substantial
burden
on
healthcare
systems
society.
A
major
obstacle
in
treating
these
conditions
is
blood-brain
barrier
(BBB),
which
restricts
passage
therapeutic
agents
brain.
Nanotechnology,
particularly
use
nanoparticles
(NPs),
offers
promising
solution
this
challenge.
NPs
possess
unique
properties
such
as
small
size,
large
surface
area,
modifiable
characteristics,
enabling
them
cross
BBB
deliver
drugs
directly
affected
brain
regions.
This
review
focuses
application
gene
therapy
enzyme
replacement
(ERT)
for
disorders.
Gene
involves
altering
or
manipulating
expression
can
be
enhanced
by
designed
carry
various
genetic
materials.
Similarly,
improve
efficacy
ERT
lysosomal
storage
(LSDs)
facilitating
delivery
brain,
overcoming
issues
like
immunogenicity
instability.
Taken
together,
explores
potential
revolutionizing
treatment
options
highlighting
their
advantages
future
directions
rapidly
evolving
field.
Keywords:
system,
nanoparticle,
therapy,
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(29), P. 19232 - 19246
Published: July 12, 2024
Despite
the
superior
efficacy
of
radiotherapy
in
esophageal
squamous
cell
carcinoma
(ESCC),
radioresistance
by
cancer
stem
cells
(CSCs)
leads
to
recurrence,
metastasis,
and
treatment
failure.
Therefore,
it
is
necessary
develop
CSC-based
therapies
enhance
radiotherapy.
miR-339-5p
(miR339)
involved
division
DNA
damage
checkpoint
signaling
pathways
based
on
ESCC
cohort.
miR339
inhibited
stemness
enhanced
radiation-induced
targeting
USP8,
suggesting
that
acts
as
a
potential
CSC
regulator
radiosensitizer.
Considering
limited
circulating
periods
poor
tumor-targeting
ability
miRNA,
multifunctional
nanoplatform
bismuth
sulfide
nanoflower
(Bi@PP)
developed
efficiently
deliver
improve
radioresistance.
Intriguingly,
Bi@PP
encapsulates
more
owing
their
flower-shaped
structure,
delivering
than
1000-fold
into
cells,
free
alone.
Besides
being
used
carrier,
advantageous
for
dynamically
monitoring
distribution
delivered
vivo
while
simultaneously
inhibiting
tumor
growth.
Additionally,
Bi@PP/miR339
can
significantly
patient-derived
xenograft
models.
This
platform,
incorporating
higher
miRNA
loading
capacity,
pH
responsiveness,
hypoxia
relief,
CT
imaging,
provides
another
method
promote
radiosensitivity
optimize
treatment.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 9175 - 9193
Published: Sept. 1, 2024
Ischemic
stroke
is
a
refractory
disease
wherein
the
reperfusion
injury
caused
by
sudden
restoration
of
blood
supply
main
cause
increased
mortality
and
disability.
However,
current
therapeutic
strategies
for
inflammatory
response
induced
cerebral
ischemia-reperfusion
(I/R)
are
unsatisfactory.
This
study
aimed
to
develop
functional
nanoparticle
(MM/ANPs)
comprising
apelin-13
(APNs)
encapsulated
in
macrophage
membranes
(MM)
modified
with
distearoyl
phosphatidylethanolamine-polyethylene
glycol-RVG29
(DSPE-PEG-RVG29)
achieve
targeted
therapy
against
ischemic
stroke.
Cells,
Journal Year:
2023,
Volume and Issue:
12(10), P. 1378 - 1378
Published: May 13, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
with
dysfunction
of
memory,
language
and
thinking.
More
than
55
million
people
were
diagnosed
AD
or
other
dementia
around
the
world
in
2020.
The
pathology
still
unclear
there
are
no
applicable
therapies
for
AD.
MicroRNAs
(miRNAs)
play
key
roles
have
great
potential
diagnosis
treatment
Extracellular
vesicles
(EVs)
widely
exist
body
fluids
such
as
blood
cerebrospinal
fluid
(CSF)
contain
miRNAs
that
involved
cell-to-cell
communication.
We
summarized
dysregulated
EVs
derived
from
different
patients,
well
their
function
application
also
compared
these
to
those
brain
tissues
patients
aiming
provide
comprehensive
view
After
careful
comparisons,
we
found
miR-125b-5p
miR-132-3p
upregulated
downregulated
several
AD,
respectively,
suggesting
value
based
on
EV
miRNAs.
Furthermore,
miR-9-5p
was
had
been
tested
therapy
mice
human
cell
models,
could
be
used
design
new
Sustainability,
Journal Year:
2023,
Volume and Issue:
15(5), P. 4638 - 4638
Published: March 5, 2023
Due
to
its
distinct,
atypical
features
and
possible
applications,
three-dimensional
(3D)
hierarchical
nanoflowers
have
sparked
considerable
interest.
Copper
(II)
ions
were
employed
as
inorganic
components
in
this
study,
whereas
various
extracts
from
Aspergillus
terreus
their
extracted
main
used
organic
components.
Extracts
A.
isolated
principal
component
molecules
can
first
form
complexes
with
copper
ions,
these
subsequently
become
nucleation
sites
for
primary
phosphate
crystals,
showing
interactions
using
an
easy
successful
self-assembly
template
synthesis
technique.
Therefore,
the
process
results
formation
of
3D
among
extract
remoted
important
additives
addition
ensuing
a
completely
unique
round
flower-like
shape
containing
loads
nanopetals
under
most
excellent
conditions
along
pH,
attention
organic–inorganic
additives,
temperature,
quantity
nitrate
on
nanoflower
formation.
Furthermore,
major
components,
Cu3(PO4)2
nanoflowers,
seemed
remarkable
antibacterial
effect.
Our
findings
highlight
benefits
made
secondary
metabolites
structures,
which
could
be
industrial
biocatalysts,
biosensors,
environmental
chemistry.
Molecular Neurobiology,
Journal Year:
2023,
Volume and Issue:
60(10), P. 5557 - 5577
Published: June 16, 2023
Abstract
Neurodegenerative
disorders
(NDD)
have
grabbed
significant
scientific
consideration
due
to
their
fast
increase
in
prevalence
worldwide.
The
specific
pathophysiology
of
the
disease
and
amazing
changes
brain
that
take
place
as
it
advances
are
still
top
issues
contemporary
research.
Transcription
factors
play
a
decisive
role
integrating
various
signal
transduction
pathways
ensure
homeostasis.
Disruptions
regulation
transcription
can
result
pathologies,
including
NDD.
Numerous
microRNAs
epigenetic
emerged
candidates
for
determining
precise
etiology
Consequently,
understanding
by
what
means
regulated
how
deregulation
contributes
neurological
dysfunction
is
important
therapeutic
targeting
they
modulate.
RE1-silencing
factor
(REST)
also
named
neuron-restrictive
silencer
(NRSF)
has
been
studied
REST
was
realized
be
part
neuroprotective
element
with
ability
tuned
influenced
numerous
microRNAs,
such
124,
132,
9
implicated
This
article
looks
at
influence
controlling
function
progression
Alzheimer’s
(AD),
Parkinson’s
(PD),
Huntington’s
(HD)
disease.
Furthermore,
therapeutically
exploit
possibility
we
bring
forth
an
overview
drug-delivery
systems
modulate
regulating
Graphical
abstract
Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
35(3), P. 419 - 431
Published: March 7, 2024
The
design
of
a
potent
amyloid-β
protein
(Aβ)
inhibitor
plays
pivotal
role
in
the
prevention
and
treatment
Alzheimer's
disease
(AD).
Despite
endogenous
transthyretin
(TTR)
being
recognized
as
an
Aβ
inhibitor,
weak
inhibitory
blood
brain
barrier
(BBB)
crossing
capabilities
hinder
it
for
aggregation
inhibition
transport.
Therefore,
we
have
herein
designed
recombinant
TTR
by
conjugating
cationic
cell
penetrating
peptide
(penetratin,
Pen),
which
not
only
enabled
fusion
protein,
TTR-Pen
(TP),
to
present
high
BBB
penetration
but
also
greatly
enhanced
potency
inhibition.
Namely,
made
TP
positively
charged,
leading
suppression
