Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Owing
to
the
unpredictable
size
of
wounds
and
irregular
edges
formed
by
trauma,
nanofibers’
highly
customizable
adherent
in
situ
deposition
can
contribute
intervention
healing
process.
However,
electrospinning
is
limited
constraints
conventional
polymeric
materials
despite
its
potential
for
anti-inflammatory
antimicrobial
properties.
Here,
inspired
Janus
structure
biochemistry
nanometal
ions,
we
developed
an
sprayed
method
overcome
bacterial
infections
immune
imbalances
during
wound
healing.
The
bilayer
fiber
scaffold
has
a
hydrophobic
outer
layer
composed
polycaprolactone
(PCL)
hydrophilic
inner
gelatin,
poly(L-lactic
acid)
(PLLA),
magnesium
oxide
nanoparticles,
constituting
PCL/PLLA-gelatin-MgO
(PPGM)
electrospun
scaffold.
This
blocked
colonization
growth
bacteria
remained
stable
on
continuous
properties
promote
Furthermore,
PPGM
modulated
collagen
inflammatory
microenvironment
full-thickness
skin
model,
significantly
accelerating
vascularization
epithelialization
progression.
personalized
excellent
as
new
type
dressing
first
aid
healthcare.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1177 - 1177
Published: May 31, 2022
Tissue
engineering
has
become
a
medical
alternative
in
this
society
with
an
ever-increasing
lifespan.
Advances
the
areas
of
technology
and
biomaterials
have
facilitated
use
engineered
constructs
for
issues.
This
review
discusses
on-going
concerns
latest
developments
widely
employed
biomaterial
field
tissue
engineering:
gelatin.
Emerging
techniques
including
3D
bioprinting
gelatin
functionalization
demonstrated
better
mimicking
native
by
reinforcing
gelatin-based
systems,
among
others.
breakthrough
facilitates,
on
one
hand,
manufacturing
process
when
it
comes
to
practicality
cost-effectiveness,
which
plays
key
role
transition
towards
clinical
application.
On
other
can
be
concluded
that
could
considered
as
promising
future
trends,
focus
might
detection
diagnosis
diseases
rather
than
treatment.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(6), P. 2015 - 2039
Published: Jan. 1, 2023
Increasing
data
reveals
that
gelatin
has
been
methacrylated
is
involved
in
a
variety
of
physiologic
processes
are
important
for
therapeutic
interventions.
Gelatin
methacryloyl
(GelMA)
hydrogel
highly
attractive
hydrogels-based
bioink
because
its
good
biocompatibility,
low
cost,
and
photo-cross-linking
structure
useful
cell
survivability
monitoring.
Methacrylated
established
itself
as
typical
composition
with
extensive
biomedical
applications.
Recent
advances
GelMA
have
focused
on
integrating
them
bioactive
functional
nanomaterials,
the
goal
improving
GelMA's
physical,
chemical,
biological
properties.
ability
to
modify
characteristics
due
synthesis
technique
also
makes
it
choice
soft
hard
tissues.
become
an
independent
or
supplementary
technology
musculoskeletal
problems.
Here,
we
systematically
review
mechanism-of-action,
uses,
challenges
future
direction
disorders.
We
give
overview
nanocomposite
different
applications
disorders,
such
osteoarthritis,
intervertebral
disc
degeneration,
bone
regeneration,
tendon
disorders
so
on.
Gels,
Journal Year:
2023,
Volume and Issue:
9(5), P. 373 - 373
Published: May 1, 2023
Chitosan
hydrogels
have
a
wide
range
of
applications
in
tissue
engineering
scaffolds,
mainly
due
to
the
advantages
their
chemical
and
physical
properties.
This
review
focuses
on
application
chitosan
scaffolds
for
vascular
regeneration.
We
introduced
these
following
aspects:
progress
regeneration
modification
improve
Finally,
this
paper
discusses
prospects
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
Macromolecular Bioscience,
Journal Year:
2022,
Volume and Issue:
23(2)
Published: Nov. 21, 2022
The
development
of
tissue
engineering
scaffolds
is
great
significance
for
the
repair
and
regeneration
damaged
tissues
organs.
Silk
fibroin
(SF)
a
natural
protein
polymer
with
good
biocompatibility,
biodegradability,
excellent
physical
mechanical
properties
processability,
making
it
an
ideal
universal
scaffold
material.
Nanofibers
prepared
by
electrospinning
have
attracted
extensive
attention
in
field
due
to
their
properties,
high
specific
surface
area,
similar
morphology
as
extracellular
matrix
(ECM).
combination
silk
promising
strategy
preparation
scaffolds.
In
this
review,
research
progress
electrospun
nanofibers
skin,
vascular,
bone,
neural,
tendons,
cardiac,
periodontal,
ocular
other
discussed
detail.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(16)
Published: Feb. 8, 2023
Abstract
Extracellular
matrix
(ECM)
proteins
containing
cell‐attachable
Arg‐Gly‐Asp
(RGD)
sequences
exhibit
variable
bridging
and
non‐bridging
in
fibronectin‐collagen
laminin‐collagen
complexes
that
can
regulate
inflammation,
tissue
repair,
wound
healing.
In
this
study,
linking
molecule‐mediated
conjugation
of
1D
magnetic
nanocylinders
(MNCs)
to
material
surfaces
pre‐decorated
with
gold
nanospheres
(GNSs)
is
performed,
thereby
yielding
RGD‐coated
MNCs
(RGD‐MNCs)
over
GNSs
(RGD‐GNSs)
a
state.
The
RGD‐MNCs
are
drawn
closer
the
RGD‐GNSs
via
field‐mediated
compression
molecules
establish
between
them.
Relative
proportion
optimized
yield
effective
remote
stimulation
integrin
binding
variably
bridged
RGDs
similar
invariably
used
as
control
group.
Remote
manipulation
RGD
facilitates
attachment
structure
assembly
macrophages
leads
pro‐healing/anti‐inflammatory
phenotype
acquisition.
contrast,
non‐bridged
inhibited
macrophage
acquired
pro‐inflammatory
phenotypes.
use
various
nanomaterials
constructing
heterogeneous
materials
further
offer
modes
switching
understand
dynamic
integrin‐mediated
modulation
immunomodulatory
responses,
such
foreign
body
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Electrospinning
is
a
significant
manufacturing
strategy
to
create
micro/nanofiber
platforms
that
can
be
considered
biomedical
scaffold
for
tissue
engineering
repair
and
regeneration.
In
recent
years
researchers
have
continuously
broadened
the
equipment
design
materials
development
of
electrospinning
nanofiber
(ENPs),
which
evolved
from
single‐needle
multi‐needle
creating
3D
ENPs,
diversify
their
application
including
drugs/cell/growth
factors
release,
anti‐bacterial
anti‐inflammatory,
hemostasis,
wound
healing,
Herein,
multifunctional
ENPs
with
bioactive
polymer
fabricated
via
in
terms
novel
material
design,
construction
various
structures,
requirements
different
regeneration
are
reviewed.
Furthermore,
this
review
delves
into
advancements
facilitated
by
highlighting
effectiveness
versatility
across
types
such
as
bone,
cartilage,
tendons,
cardiac
tissue,
nerves.
The
discussion
comprehensively
addresses
ongoing
challenges
selection,
biodegradation
mechanisms,
bioactivation
strategies,
techniques
specific
applications.
Moreover,
outlines
potential
future
research
avenues
aimed
at
enhancing
ENPs‐based
approaches
engineering.
This
in‐depth
analysis
aims
provide
nuanced
insights
technical
recommendations
propel
field
forward
Macromolecular Materials and Engineering,
Journal Year:
2024,
Volume and Issue:
309(5)
Published: March 12, 2024
Abstract
Silk
fibroin
(SF),
a
natural
protein
derived
from
silkworms,
has
emerged
as
promising
biomaterial
due
to
its
biocompatibility,
biodegradability,
degradation
rate,
and
tunable
mechanical
properties.
This
review
delves
into
the
intrinsic
attributes
of
SF
that
make
it
an
attractive
candidate
for
scaffold
development
in
tissue
engineering
regenerative
medicine.
The
distinctiveness
this
comprehensive
resides
detailed
exploration
recent
advancements
fabrication
techniques
SF‐based
fibrous
scaffolds,
namely
electrospinning,
freeze‐drying,
3D
printing.
An
in‐depth
analysis
these
is
conducted
illustrate
their
versatility
customizing
essential
characteristics,
such
porosity,
fiber
diameter,
strength.
article
meticulously
discusses
process
parameters,
advantages,
challenges
each
technique,
highlighting
innovative
made
respective
field.
Furthermore,
goes
beyond
provide
overview
latest
biomedical
applications
research
endeavors
utilizing
SF‐derived
scaffolds.
From
nerve
regeneration
wound
healing
drug
delivery,
bone
regeneration,
vascular
engineering,
diverse
underscore
adopting
various
challenges.
Finally,
emphasizes
need
standardized
characterization
techniques,
scalable
manufacturing
processes,
long‐term
vivo
studies.
