Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Owing
to
the
unpredictable
size
of
wounds
and
irregular
edges
formed
by
trauma,
nanofibers’
highly
customizable
adherent
in
situ
deposition
can
contribute
intervention
healing
process.
However,
electrospinning
is
limited
constraints
conventional
polymeric
materials
despite
its
potential
for
anti-inflammatory
antimicrobial
properties.
Here,
inspired
Janus
structure
biochemistry
nanometal
ions,
we
developed
an
sprayed
method
overcome
bacterial
infections
immune
imbalances
during
wound
healing.
The
bilayer
fiber
scaffold
has
a
hydrophobic
outer
layer
composed
polycaprolactone
(PCL)
hydrophilic
inner
gelatin,
poly(L-lactic
acid)
(PLLA),
magnesium
oxide
nanoparticles,
constituting
PCL/PLLA-gelatin-MgO
(PPGM)
electrospun
scaffold.
This
blocked
colonization
growth
bacteria
remained
stable
on
continuous
properties
promote
Furthermore,
PPGM
modulated
collagen
inflammatory
microenvironment
full-thickness
skin
model,
significantly
accelerating
vascularization
epithelialization
progression.
personalized
excellent
as
new
type
dressing
first
aid
healthcare.
Regenerative Biomaterials,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 1, 2022
Abstract
With
an
increase
in
life
expectancy
and
the
popularity
of
high-intensity
exercise,
frequency
tendon
ligament
injuries
has
also
increased.
Owing
to
specificity
its
tissue,
rapid
restoration
injured
tendons
ligaments
is
challenging
for
treatment.
This
review
summarizes
latest
progress
cells,
biomaterials,
active
molecules
construction
technology
treating
tendon/ligament
injuries.
The
characteristics
supports
made
different
materials
development
application
manufacturing
methods
are
discussed.
natural
polymers,
synthetic
polymers
composite
boosted
use
scaffolds.
In
addition,
electrospinning
hydrogel
diversified
production
treatment
materials.
First,
this
article
briefly
introduces
structure,
function
biological
tendons/ligaments.
Then,
it
advantages
disadvantages
materials,
such
as
polymer
scaffolds,
scaffolds
extracellular
matrix
(ECM)-derived
regeneration.
We
then
discuss
applications
electrospun
fiber
hydrogels
regeneration
engineering.
Finally,
we
current
problems
future
directions
biomaterials
restoring
damaged
ligaments.
Biomimetics,
Journal Year:
2023,
Volume and Issue:
8(2), P. 246 - 246
Published: June 9, 2023
Tendon
tissue
connects
muscle
to
bone
and
plays
crucial
roles
in
stress
transfer.
injury
remains
a
significant
clinical
challenge
due
its
complicated
biological
structure
poor
self-healing
capacity.
The
treatments
for
tendon
have
advanced
significantly
with
the
development
of
technology,
including
use
sophisticated
biomaterials,
bioactive
growth
factors,
numerous
stem
cells.
Among
these,
biomaterials
that
mimic
extracellular
matrix
(ECM)
would
provide
resembling
microenvironment
improve
efficacy
repair
regeneration.
In
this
review,
we
will
begin
description
constituents
structural
features
tissue,
followed
by
focus
on
available
biomimetic
scaffolds
natural
or
synthetic
origin
engineering.
Finally,
discuss
novel
strategies
present
challenges
regeneration
repair.
International Journal of Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
52(2)
Published: June 30, 2023
Tendon
injury
is
a
common
disorder
of
the
musculoskeletal
system
caused
by
overuse
or
trauma.
With
increasing
incidence
tendon
injuries,
it
necessary
to
find
an
effective
treatment.
Mesenchymal
stem
cells
(MSCs)
are
attracting
attention
because
their
high
proliferative
and
self‑renewal
capacity.
These
functions
MSCs
show
promise
in
treating
variety
diseases,
including
immune
cardiovascular
disease,
especially
satisfactory
effects
treatment
injury.
First,
since
have
multidirectional
differentiation
potential,
they
differentiate
into
specific
after
induction
in
vivo
vitro.
Furthermore,
paracrine
can
secrete
biologically
active
molecules
exosomes
such
as
cytokines,
growth
factors
chemokines
promote
tissue
repair
regeneration.
In
injury,
through
four
mechanisms:
Decreasing
inflammation
promoting
neovascularization
cell
proliferation
differentiation.
They
also
involved
extracellular
matrix
reorganization
collagen
production
transforming
type
III
fibers
I
fibers.
The
present
review
summarized
preclinical
experiments
with
different
sources
mechanisms
repair,
well
limitations
current
clinical
applications
directions
that
need
be
explored
future.
Biomimetics,
Journal Year:
2023,
Volume and Issue:
8(1), P. 55 - 55
Published: Jan. 28, 2023
Biomaterial
research
has
led
to
revolutionary
healthcare
advances.
Natural
biological
macromolecules
can
impact
high-performance,
multipurpose
materials.
This
prompted
the
quest
for
affordable
solutions,
with
a
focus
on
renewable
biomaterials
wide
variety
of
applications
and
ecologically
friendly
techniques.
Imitating
their
chemical
compositions
hierarchical
structures,
bioinspired
based
materials
have
elevated
rapidly
over
past
few
decades.
Bio-inspired
strategies
entail
extracting
fundamental
components
reassembling
them
into
programmable
biomaterials.
method
may
improve
its
processability
modifiability,
allowing
it
meet
application
criteria.
Silk
is
desirable
biosourced
raw
material
due
high
mechanical
properties,
flexibility,
bioactive
component
sequestration,
controlled
biodegradability,
remarkable
biocompatibility,
inexpensiveness.
regulates
temporo-spatial,
biochemical
biophysical
reactions.
Extracellular
factors
regulate
cellular
destiny
dynamically.
review
examines
structural
functional
properties
silk
scaffolds.
We
explored
types,
composition,
architecture,
topography,
3D
geometry
unlock
body’s
innate
regenerative
potential,
keeping
in
mind
novel
film,
fiber,
other
potential
forms,
coupled
facile
changes,
ability
match
requirements
specific
tissues.
Medicina,
Journal Year:
2023,
Volume and Issue:
59(8), P. 1449 - 1449
Published: Aug. 10, 2023
Soft
tissue
regeneration
holds
significant
promise
for
addressing
various
clinical
challenges,
ranging
from
craniofacial
and
oral
defects
to
blood
vessels,
muscle,
fibrous
regeneration.
Mesenchymal
stem
cells
(MSCs)
have
emerged
as
a
promising
tool
in
regenerative
medicine
due
their
unique
characteristics
potential
differentiate
into
multiple
cell
lineages.
This
comprehensive
review
explores
the
role
of
MSCs
different
aspects
soft
regeneration,
including
application
nerve
vessel
muscle
By
examining
latest
research
findings
advancements,
this
article
aims
provide
insights
current
state
MSC-based
therapies
medicine.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
review
summarizes
the
hierarchical
structure
and
multifaceted
properties
of
natural
silk
fibers,
provides
an
in-depth
analysis
their
extensive
applications
in
realms
biomedicine
advanced
smart
fiber
technology.
Advanced NanoBiomed Research,
Journal Year:
2022,
Volume and Issue:
2(11)
Published: Sept. 15, 2022
Multifunctional
magnetic
nanoparticles
(MNPs)
exhibit
unique
properties,
such
as
remote
motion
controllability,
degradability,
and
diagnostic
imaging,
which
are
typically
not
shown
in
nonmagnetic
nanomaterials.
MNPs
remotely
controllable
via
fields
offer
advantages
of
high
tissue
penetrability
biocompatibility.
In
this
review,
recent
advances
multifunctional
exhibiting
characteristic
for
therapeutic
applications
summarized,
utilize
the
“dynamic”
motion,
iron
ion
degradation,
or
imaging‐guided
targeting
under
diverse
field
modes.
The
field‐controlled
MNP
enables
spatiotemporal
reversible
situ
cell
regulation
mechanosensitive
molecule
modulation
thermal
energy
generation.
Furthermore,
iron‐based
can
produce
degraded
ions
reactive
oxygen
species
to
enable
targeted
ferroptosis
therapy
with
medical
approaches.
state‐of‐the‐art
using
that
provide
feedback
at
each
stage
is
highlighted.
Potential
hurdles
translating
dynamic
imaging
toward
clinical
practices
also
discussed.
capability
during
magneto‐cell
noninvasive,
safe,
localized,
on‐demand
regenerative
therapy,
immunotherapy,
cancer
treatment.
