Cells,
Journal Year:
2023,
Volume and Issue:
12(18), P. 2293 - 2293
Published: Sept. 16, 2023
Healing
of
dense
regular
connective
tissue,
due
to
a
high
fiber-to-cell
ratio
and
low
metabolic
activity
regeneration
potential,
frequently
requires
surgical
implantation
or
reconstruction
with
risk
reinjury.
An
alternative
synthetic
implants
is
using
bioscaffolds
obtained
through
decellularization,
process
where
the
aim
extract
cells
from
tissue
while
preserving
tissue-specific
native
molecular
structure
ECM.
Proteins,
lipids,
nucleic
acids
other
various
extracellular
molecules
are
largely
involved
in
differentiation,
proliferation,
vascularization
collagen
fibers
deposit,
making
them
crucial
processes
regeneration.
Because
multiple
possible
forms
cell
extraction,
there
no
standardized
protocol
(DRCT).
Many
modifications
structure,
shape
composition
bioscaffold
have
also
been
described
improve
therapeutic
result
following
decellularized
tissue.
The
available
data
provide
valuable
source
information.
However,
wide
spectrum
decellularization
makes
it
important
understand
key
aspects
relative
their
potential
use
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(6), P. 060501 - 060501
Published: Oct. 10, 2024
The
pursuit
of
sustainable
bioinspired
materials
for
regenerative
medicine
demands
a
nuanced
balance
between
scientific
advancement,
ethical
considerations,
and
environmental
consciousness.
This
abstract
encapsulates
comprehensive
perspective
paper
exploring
the
intricate
dynamics
toxicology,
impact,
concerns
within
realm
materials.
As
landscape
evolves,
ensuring
biocompatibility
safety
these
emerges
as
pivotal
challenge.
Our
delves
into
multidimensional
aspects
toxicity
assessment,
encompassing
cytotoxicity,
genotoxicity,
immunotoxicity
analyses.
Additionally,
we
shed
light
on
complexities
evaluating
impact
materials,
discussing
methodologies
such
life
cycle
biodegradability
testing,
design
approaches.
Amid
endeavors,
emphasize
paramount
importance
considerations
in
material
development,
navigating
web
international
regulations
frameworks
guiding
medical
Furthermore,
our
underscores
envisioned
future
directions
challenges
toxicology
techniques,
computational
modeling,
holistic
evaluation,
aiming
understanding
synergistic
interplay
stewardship,
deliberation.
Materials Today Chemistry,
Journal Year:
2024,
Volume and Issue:
37, P. 102016 - 102016
Published: April 1, 2024
Tissue-engineered
constructs
can
replicate
the
structural
and
physiological
properties
of
natural
tissues.
The
be
designed
to
address
transplantation
issues
affected
by
shortage
donor
tissues
organs.
One
major
concerns
in
tissue
engineering
is
design
development
structures
that
improve
interaction
between
materials
cells
provide
an
ideal
platform
for
form
functional
tissue.
Several
contributing
factors
need
considered
fabricate
constructs,
including
biomaterials,
biological,
topographical,
biophysical,
morphological
either
alone
or
combination.
Here,
we
review
application,
advancement,
future
directions
these
essential
designing
developing
regeneration.
In
particular,
focus
on
original
approaches
tools
construct
parameters
engineering.
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(1), P. 37 - 37
Published: Jan. 7, 2024
Echinoderms
(starfish,
sea-urchins
and
their
close
relations)
possess
a
unique
type
of
collagenous
tissue
that
is
innervated
by
the
motor
nervous
system
whose
mechanical
properties,
such
as
tensile
strength
elastic
stiffness,
can
be
altered
in
time
frame
seconds.
Intensive
research
on
echinoderm
'mutable
tissue'
(MCT)
began
over
50
years
ago,
20
MCT
first
inspired
biomimetic
design.
MCT,
sea-cucumber
dermis
particular,
now
major
source
ideas
for
development
new
mechanically
adaptable
materials
devices
with
applications
diverse
areas
including
biomedical
science,
chemical
engineering
robotics.
In
this
review,
after
an
up-to-date
account
present
knowledge
structural,
physiological
molecular
adaptations
mechanisms
responsible
its
variable
we
focus
concept
generator
surveying
systems
biology,
showing
these
include
both
bio-derived
developments
(same
function,
analogous
operating
principles)
technology-derived
different
principles),
suggest
strategy
further
exploitation
promising
biological
resource.
Annals of Medicine,
Journal Year:
2024,
Volume and Issue:
56(1)
Published: May 13, 2024
Tendons
are
fibroblastic
structures
that
link
muscle
and
bone.
There
two
kinds
of
tendon
injuries,
including
acute
chronic.
Each
form
injury
or
deterioration
can
result
in
significant
pain
loss
function.
The
recovery
damage
is
a
complex
time-consuming
process.
Depending
on
the
anatomical
location
tissue,
clinical
outcomes
not
same.
healing
wound
process
divided
into
three
stages
overlap:
inflammation,
proliferation,
tissue
remodeling.
Furthermore,
curing
has
high
re-tear
rate.
Faced
with
challenges,
management
still
issue
must
be
resolved
as
soon
possible.
Several
newer
directions
breakthroughs
have
emerged
recent
years.
This
article
describes
summarizes
advances
recovery,
along
stem
cell
therapy,
gene
Platelet-rich
plasma
remedy,
growth
factors,
drug
treatment,
engineering.
Despite
fast-growing
research
still,
none
them
translated
to
setting.
review
provides
detailed
overview
injuries
potential
preclinical
approaches
for
treating
injuries.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
Abstract
Multi‐scale
scaffolds
with
biomimetic
extracellular
matrix
(ECM)
structures
are
crucial
for
regenerative
repair.
Nevertheless,
the
intricate
nature
of
nanostructures
presents
challenges
when
attempting
to
efficiently
manufacture
on
a
larger
scale
while
maintaining
bionics
at
nanoscale.
Here,
multiscale
scaffold
hierarchical
is
designed
address
these
challenges,
which
can
be
tendons
from
macro
and
micro
The
tendon
(MBT)
consists
shell
core.
porous
replicates
structure
sheath,
offers
mechanical
support,
facilitates
ease
sewing.
core
comprises
micro‐scale
wave
fibers
nanohybrid
Shish‐Kebab
structure,
mimic
collagen
fiber
fibril
found
in
tendons.
Additionally,
MBT
demonstrates
strong
tensile
strength
6.94
MPa
shown
enhance
adhesion
proliferation
stem/progenitor
cells
(TSPCs).
Animal
experiments
have
that
surgically
sutured
defect
area
facilitate
transduction
accelerate
regeneration
tissue.
research
combines
precise
manufacturing
nano‐structures
efficient
macro‐structure
fabrication.
It
addresses
shortcomings
disorder
fresh
approach
creating
multi‐scale
bionic
scaffolds.
Orthopedic Research and Reviews,
Journal Year:
2025,
Volume and Issue:
Volume 17, P. 105 - 113
Published: March 1, 2025
Tendon
healing
after
ligament
or
tendon
reconstruction
remains
a
significant
challenge.
Regenerative
tissue
engineering,
an
interdisciplinary
field
that
combines
biology,
materials
science,
and
offers
promising
solutions.
Recent
developments
have
introduced
scaffold
designed
to
enhance
the
proliferation
differentiation
of
tendon-to-bone
cells.
These
scaffolds
possessing
three-dimensional
composites
cells
biomaterials,
proven
effective
in
facilitating
curing
post-surgery.
The
successful
development
interface
is
critical
factor
for
early
rehabilitation
functional
recovery.
In
this
mini-review,
we
present
comprehensive
update
on
contemporary
strategies
synthetic
scaffold-based
their
influence
healing.
We
described
compositions,
structures
features
single-layer,
multi-layer,
gradient
with
special
mechanical
properties.
examined
construction
engineering
from
perspectives
biomaterials
design
strategies,
providing
evaluation
advantages
disadvantages
associated
each
approach.
Ultimately,
review
articulates
clear
research
directions
aimed
at
achieving
breakthroughs
future
studies.
Anais da Academia Brasileira de Ciências,
Journal Year:
2024,
Volume and Issue:
96(suppl 1)
Published: Jan. 1, 2024
Tendons,
complex
fibrous
structures,
are
subjected
to
great
tensions,
which
can
give
rise
the
so-called
tendinopathies.
This
study
aimed
evaluate
photobiomodulation
and
human
Amniotic
Membrane
applied
as
single
or
combined
therapies
treat
induced
Achilles
tendon
lesions.
Seventy-five
rats
were
divided
into
five
groups
(n=15):
C-
control
Sham
surgery;
I-
injury;
LA-
injury
treated
with
photobiomodulation;
AM-
Membrane;
LAM-
+
Membrane,
subdivided
three
(n=5)
analysis
at
3,
7,
14
days.
The
injuries
made
a
20
g
weight
released
from
mini
guillotine
onto
ankle
in
dorsiflexion.
AM
LAM
received
an
fragment
while
LA
transcutaneous
photobiomodulation,
using
660
nm
wavelength
laser.
inflammatory
cells
showed
statistical
differences
between
C
I
(p<0.05),
(p<0.01),
(p<0.01).
Both
shown
enhance
repair,
association
of
plus
was
most
effective
treatment.
We
conclude
that
accelerating
improving
regeneration
process.
