Biogerontology, Journal Year: 2024, Volume and Issue: 25(4), P. 583 - 613
Published: March 11, 2024
Language: Английский
Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 63, P. 159 - 170
Published: Oct. 21, 2023
Sepsis-induced cardiac injury is the leading cause of death in patients. Recent studies have reported that reactive oxygen species (ROS)-mediated ferroptosis and macrophage-induced inflammation are two main key roles process injury. The combination inhibition a feasible strategy treatment sepsis-induced
Language: Английский
Citations
18
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 22, 2024
Conventional bone tissue engineering materials struggle to reinstate physiological remodeling in a diabetic context, primarily due the compromised repolarization of proinflammatory macrophages anti-inflammatory macrophages. Here, leveraging single-cell RNA sequencing (scRNA-seq) technology, pivotal role nitric oxide (NO) and reactive oxygen species (ROS) is unveiled impeding macrophage during amidst diabetes. Guided by scRNA-seq analysis, we engineer multienzymatic hydrogel scaffold (MEBTHS) composed engineered methylpropenylated gelatin integrated with ruthenium nanozymes, possessing both Ru
Language: Английский
Citations
8
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 28, 2024
Abstract Doxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse effects on cardiac function. Previous research has demonstrated strong correlation between DOX‐induced cardiotoxicity and activation oxidative stress pathways. This work introduces novel antioxidant therapeutic approach, utilizing libraries tannic acid N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. Through extensive screening for antioxidative enzyme‐like activity, an optimal nanozyme (AuRu) identified that possess remarkable characteristics, mimicking catalase‐like enzymes. Theoretical calculations reveal surface interactions prepared nanozymes simulate hydrogen peroxide decomposition process, showing these readily undergo OH⁻ adsorption O₂ desorption. To enhance targeting, atrial natriuretic peptide conjugated AuRu nanozyme. These cardiac‐targeted nanozymes, their anchoring capability, effectively cardiomyocyte ferroptosis PANoptosis without compromising tumor treatment efficacy. Thus, approach demonstrates significant reductions in chemotherapy‐induced cell death improvements function, accompanied by exceptional vivo biocompatibility stability. study presents promising avenue preventing offering potential clinical benefits cancer patients.
Language: Английский
Citations
8
Small, Journal Year: 2024, Volume and Issue: 20(27)
Published: Feb. 5, 2024
Vascular diseases (VDs) pose the leading threat worldwide due to high morbidity and mortality. The detection of VDs is commonly dependent on individual signs, which limits accuracy timeliness therapies, especially for asymptomatic patients in clinical management. Therefore, more effective early diagnosis lesion-targeted treatments remain a pressing need. Metal-organic frameworks (MOFs) are porous crystalline materials formed by coordination inorganic metal ions organic ligands. Due their unique specific surface area, structural flexibility, functional versatility, MOFs recognized as highly promising candidates diagnostic therapeutic applications field VDs. In this review, potential act biosensors, contrast agents, artificial nanozymes, multifunctional agents treatment from perspective, highlighting integration between methods with generalized. At same time, multidisciplinary cooperation chemistry, physics, biology, medicine promote substantial commercial transformation tackling called for.
Language: Английский
Citations
7
Biogerontology, Journal Year: 2024, Volume and Issue: 25(4), P. 583 - 613
Published: March 11, 2024
Language: Английский
Citations
7