Tri-Stimulus-Responsive Hollow Mesoporous MnO2 Nanocarriers for Magnetic-Resonance-Imaging-Guided Synergistic Starvation/Photodynamic Therapy of Breast Cancer DOI

Rongjian Jiang,

Lifeng Hang, Wuming Li

et al.

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 7(1), P. 1450 - 1461

Published: Dec. 14, 2023

Hypoxia, a distinct feature of breast cancer, can affect the effectiveness cancer therapy. To alleviate hypoxic state tumor microenvironment and achieve synergistic starvation-photodynamic therapy (PDT), we have developed simple effective multifunctional nanoplatform. Spherical silica (SiO2) serves as template for synthesis hollow mesoporous MnO2 (H-MnO2) nanoparticles, which act carriers chlorin e6 (Ce6) glucose oxidase (GOx). Subsequently, particles are modified with surfactant Pluronic F-127, leading to formation H-MnO2/Ce6/GOx/F-127 (MCGF) During treatment, pH/glutathione/H2O2-responsive MCGF allows controlled release encapsulated Ce6 GOx, avoiding pre-exposure body fluids. Upon release, GOx oxidizes endogenous generate H2O2 gluconic acid. The catalase-like H-MnO2 reacts glucose-oxidation-generated produce O2. Reinforcement between these catalytic reactions promotes O2-dependent Ce6-mediated PDT GOx-induced starvation Moreover, T1-weighted magnetic resonance imaging (MRI) Mn2+, is produced by degradation, real-time monitoring. Both in vitro vivo experiments demonstrate that nanoplatform MRI monitoring achieves efficient starvation/PDT effects treatment. We believe our findings will contribute development nanotheranostic platforms starvation/PDT.

Language: Английский

A Fe2O3/CNx Cascade Nanoreactor with Dual-Enzyme-Mimetic Activities for Cancer Hypoxia Relief to Amplify Chemo/Photodynamic Therapy DOI
Lu Gan,

Yongzhi Xia,

Jie Lv

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114070 - 114070

Published: Sept. 1, 2024

Language: Английский

Citations

2
Delivery of miR‐3529‐3p using MnO2‐SiO2‐APTES nanoparticles combined with phototherapy suppresses lung adenocarcinoma progression by targeting HIGD1A DOI Creative Commons
Ying Zhang, Ranran Wang, Rui Liu

et al.

Thoracic Cancer, Journal Year: 2023, Volume and Issue: 14(10), P. 913 - 928

Published: Feb. 20, 2023

The present study aimed to investigate the function of miR-3529-3p in lung adenocarcinoma and MnO2 -SiO2 -APTES (MSA) as a promising multifunctional delivery agent for therapy.Expression levels were evaluated carcinoma cells tissues by qRT-PCR. effects on apoptosis, proliferation, metastasis neovascularization assessed CCK-8, FACS, transwell wound healing assays, tube formation xenografts experiments. Luciferase reporter western blot, qRT-PCR mitochondrial complex assay used determine targeting relationship between hypoxia-inducible gene domain family member 1A (HIGD1A). MSA was fabricated using nanoflowers, its heating curves, temperature IC50, efficiency examined. hypoxia reactive oxygen species (ROS) production investigated nitro reductase probing, DCFH-DA staining FACS.MiR-3529-3p expression reduced cells. Transfection could promote apoptosis suppress cell migration angiogenesis. As target miR-3529-3p, HIGD1A downregulated, through which disrupt activities complexes III IV respiratory chain. nanoparticle not only efficiently deliver into cells, but also enhance antitumor miR-3529-3p. underlying mechanism may be that alleviates has synergistic cellular ROS promotion with miR-3529-3p.Our results establish antioncogenic role demonstrate delivered enhanced tumor suppressive effects, probably elevating thermogenesis.

Language: Английский

Citations

5
Multimodal imaging and photothermal/chemodynamic therapy of cervical cancer using GSH-responsive MoS2@MnO2 theranostic nanoparticles DOI Creative Commons

Runrun Shao,

Xiaofang Qiao, Linlin Cao

et al.

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Sept. 29, 2023

The development of nanoparticles capable inducing reactive oxygen species (ROS) formation has become an important strategy for cancer therapy. Simultaneously, the preparation multifunctional that respond to tumor microenvironment is crucial diagnosis and treatment tumors. In this study, we designed a Molybdenum disulfide (MoS2) core coated with Manganese dioxide (MnO2), which possessed good photothermal effect could produce Fenton-like Mn2+ in response highly expressed glutathione (GSH) microenvironment, thereby generating chemodynamic therapy (CDT). were further modified Methoxypoly(Ethylene Glycol) 2000 (mPEG-NH2) improve their biocompatibility, resulting MoS2@MnO2-PEG. These shown possess significant Magnetic Resonance Imaging (MRI) Computed Tomography (CT) imaging capabilities, making them useful diagnosis. vitro vivo experiments demonstrated antitumor ability MoS2@MnO2-PEG, killing on cells under combined treatment. hold great potential CDT/photothermal (PTT) be explored biomedical research.

Language: Английский

Citations

5
Single-Atom Nanoenzyme-Based Autoluminescence System for Cancer Cell Imaging and Mitochondrial-Targeted Therapy DOI
Feng Lu, Haijun Yu,

Zhiru Bi

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(11), P. 5086 - 5096

Published: Nov. 9, 2023

The autoluminescence nanoplatform based on a single-atom catalyst has the potential to achieve accurate tumor diagnosis and treatment. Taking advantage of this, glycyrrhetinic acid (GA) chitosan-modified single Fe-N-C atom catalysts (SAF NPs) loaded with luminol-curcumin (Cur) were fabricated (SAF-LCCG). Once delivered tumor, this SAF-LCCG could target mitochondria restrain metastasis promote production hydrogen peroxide (H2O2). Then, SAF NPs Fenton-like properties actively utilize intracellular H2O2 produce ·OH for chemodynamic therapy. After that, excess transmitted luminol emit blue-violet chemiluminescence (CL) cancer cell imaging. Synchronously, light was transferred Cur reactive oxygen species (ROS) which realized photodynamic Besides, be served as chemotherapeutic drug enhance ROS penetrating More importantly, massive accumulation in cells can CL intensity luminol, cyclic amplification. This developed imaging, effective inhibition metastasis, synergistic penetrated treatment tumors.

Language: Английский

Citations

5
Tri-Stimulus-Responsive Hollow Mesoporous MnO2 Nanocarriers for Magnetic-Resonance-Imaging-Guided Synergistic Starvation/Photodynamic Therapy of Breast Cancer DOI

Rongjian Jiang,

Lifeng Hang, Wuming Li

et al.

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 7(1), P. 1450 - 1461

Published: Dec. 14, 2023

Hypoxia, a distinct feature of breast cancer, can affect the effectiveness cancer therapy. To alleviate hypoxic state tumor microenvironment and achieve synergistic starvation-photodynamic therapy (PDT), we have developed simple effective multifunctional nanoplatform. Spherical silica (SiO2) serves as template for synthesis hollow mesoporous MnO2 (H-MnO2) nanoparticles, which act carriers chlorin e6 (Ce6) glucose oxidase (GOx). Subsequently, particles are modified with surfactant Pluronic F-127, leading to formation H-MnO2/Ce6/GOx/F-127 (MCGF) During treatment, pH/glutathione/H2O2-responsive MCGF allows controlled release encapsulated Ce6 GOx, avoiding pre-exposure body fluids. Upon release, GOx oxidizes endogenous generate H2O2 gluconic acid. The catalase-like H-MnO2 reacts glucose-oxidation-generated produce O2. Reinforcement between these catalytic reactions promotes O2-dependent Ce6-mediated PDT GOx-induced starvation Moreover, T1-weighted magnetic resonance imaging (MRI) Mn2+, is produced by degradation, real-time monitoring. Both in vitro vivo experiments demonstrate that nanoplatform MRI monitoring achieves efficient starvation/PDT effects treatment. We believe our findings will contribute development nanotheranostic platforms starvation/PDT.

Language: Английский

Citations

5