Accessing
each
enantiomers
of
a
chiral
molecule
starting
from
racemic
mixture
remains
daunting
challenge
in
chemistry.
Indeed,
until
now
only
few
solutions
exist
to
separate
an
equimolar
precursor.
In
this
study,
we
establish
new
strategy
prepare
simultaneously
and
physically
both
enantioenriched
substrate.
This
process
combines
two
enantiomeric
catalytic
systems,
working
parallel
separation
by
achiral
membrane
with
selective
permeability.
unprecedented
system
was
successfully
applied
the
simultaneous
preparation
1,2-diols
epoxides
using
Jacobsen’s
hydrolytic
kinetic
resolution
(HKR)
parallel.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(29)
Published: May 9, 2024
Membrane-based
enantioselective
separation
is
a
promising
method
for
chiral
resolution
due
to
its
low
cost
and
high
efficiency.
However,
scalable
fabrication
of
membranes
displaying
both
enantioselectivity
flux
enantiomers
still
challenge.
Here,
the
authors
report
preparation
homochiral
porous
organic
cage
(Covalent
3
(CC3)-R)-based
thin-film-composite
using
polyamide
(PA)
as
matrix,
where
fully
solvent-processable
crystals
have
good
compatibility
with
polymer
scaffold.
The
hierarchical
CC3-R
channels
consist
selective
windows
inner
cavities,
leading
favorable
permeation
enantiomers;
CC3-R/PA
composite
display
an
enantiomeric
excess
95.2%
R-(+)-limonene
over
S-(-)-limonene
99.9
mg
h
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(50), P. 27236 - 27241
Published: Dec. 11, 2023
Accessing
each
enantiomer
of
a
chiral
molecule
starting
from
racemic
mixture
remains
daunting
challenge
in
chemistry.
Indeed,
until
now,
only
few
solutions
exist
to
separate
enantiomers
an
equimolar
precursor.
In
this
study,
we
establish
new
strategy
prepare
simultaneously
and
physically
both
enantioenriched
substrate.
This
process
combines
two
enantiomeric
catalytic
systems,
working
parallel,
separation
by
achiral
membrane
with
selective
permeability.
unprecedented
system
was
successfully
applied
the
simultaneous
preparation
1,2-diols
epoxides
using
Jacobsen's
hydrolytic
kinetic
resolution
(HKR)
parallel.
