Liposome-coated nanoparticle triggers prostate cancer ferroptosis through synergetic chemodynamic-gas therapy

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 6(2), P. 524 - 533

Published: Dec. 19, 2023

Lpo@MnS-GOx induced prostate cancer ferroptosis through Chemodynamic-Gas therapy, which combined with starvation therapy exhibited co-enhanced anti-tumor effect.

Language: Английский

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Research progress on graphene oxide nanoparticle-based diagnosis and treatment platform in tumor therapy

Applied Nanoscience, Journal Year: 2024, Volume and Issue: 14(2), P. 411 - 421

Published: Jan. 4, 2024

Language: Английский

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NIR Absorbing Organic Chromophores Combination with NSAIDs for Remodeling of the Inflammatory Microenvironment to Amplify Tumor Ferroptosis‐Photothermal Synergistic Therapy

Small, Journal Year: 2024, Volume and Issue: 20(33)

Published: May 6, 2024

Abstract Photothermal therapy has emerged as a promising approach for cancer treatment, which can cause ferroptosis to enhance immunotherapeutic efficacy. However, excessively generated immunogenicity will induce serious inflammatory response syndrome, resulting in discounted therapeutic effect. Herein, kind of NIR absorption small organic chromophore nanoparticles (TTHM NPs) with high photothermal conversion efficiency (68.33%) is developed, mitochondria dysfunction, generate mitochondrial superoxide, and following ferroptosis. TTHM NPs‐based combined Sulfasalazine (SUZ), nonsteroidal anti‐inflammatory drugs, weaken inflammation promote through suppressing glutamate/cystine (Glu/Cys) antiporter system Xc − (xCT). Additionally, the combination SUZ PTT immunogenic cell death (ICD), followed by promoting maturation DCs attraction CD8 + T cell, secrete IFN‐γ trigger self‐amplified via inhibiting xCT simulating Acyl‐CoA synthetase long‐chain family member 4 (ACSL4). Moreover, vivo results demonstrate that this suppress expression factors, dendritic activation, facilitate T‐cell infiltration, realize effective thermal elimination primary tumors distant tumors. In general, work provides an excellent example medication stimulates new thinking about onco‐therapy response.

Language: Английский

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Chemical Biology Perspectives on STING Agonists as Tumor Immunotherapy

ChemMedChem, Journal Year: 2023, Volume and Issue: 18(23)

Published: Oct. 5, 2023

Abstract Stimulator of interferon genes (STING) is a crucial adaptor protein in the innate immune response. STING activation triggers cytokine secretion, including type I and initiates T cell‐mediated adaptive immunity. The activated system converts “cold tumors” into “hot that are highly responsive to cells by recruiting them tumor microenvironment, ultimately leading potent long‐lasting antitumor effects. Unlike most checkpoint inhibitors, agonists represent groundbreaking class hold great potential for effectively targeting various cancer populations poised become blockbuster immunotherapy. This review will focus on correlation between signaling pathway immunity, as well explore impact other biological processes. Ultimately, we summarize development optimization from medicinal chemistry perspective, evaluate their therapy, identify possible challenges future advancement.

Language: Английский

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Nanomotors activating both cGAS-STING pathway and immune checkpoint blockade for tumor therapy and bioimaging

Talanta, Journal Year: 2024, Volume and Issue: 284, P. 127258 - 127258

Published: Nov. 20, 2024

Language: Английский

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