Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(5), P. 413 - 413

Published: Feb. 23, 2024

Recent strides in nanomaterials science have paved the way for creation of reliable, effective, highly accurate, and user-friendly biomedical systems. Pioneering integration natural cell membranes into sophisticated nanocarrier architectures, membrane camouflage has emerged as a transformative approach regulated drug delivery, offering benefits minimal immunogenicity coupled with active targeting capabilities. Nevertheless, utility such is curtailed by challenges like suboptimal precision lackluster therapeutic efficacy. Tailored engineering stands at forefront biomedicine, equipping nanoplatforms capacity to conduct more complex operations. This review commences an examination prevailing methodologies engineering, spotlighting strategies direct chemical modification, lipid insertion, hybridization, metabolic glycan labeling, genetic engineering. Following this, evaluation unique attributes various presented, delivering in-depth scrutiny substantial advancements applications driven cutting-edge engineered camouflage. The discourse culminates recapitulating salient influence within nanomaterial prognosticates its seminal role healthcare technologies. It envisaged that insights offered herein will catalyze novel avenues innovation refinement camouflaged nanotechnologies.

Language: Английский

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Bone‐Targeting and Multishelled Oral Eldecalcitol Nanoparticles Improve Osteoporosis by Reconstruction of Osteogenic‐Osteoclastic Homeostasis

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 23, 2024

Abstract Current treatment of postmenopausal osteoporosis (PMOP) focuses on systemic administration medication, neglecting to proactively modulate the local microenvironment skeletal system for superior therapeutic performance. Eldecalcitol (ED‐71), a novel drug treating osteoporosis, still requires research overcome high‐frequency delivery and low‐utilization. Here, bone‐targeting multishelled nanoparticles are developed step‐wise release ED‐71. The achieved by using chitosan/alginate outer layer as protective barrier against gastric acid, pectin middle adhesive agent that improved intestinal penetration, ethylene diamine tetraacetic acid‐grafted mesoporous silica nanomaterials core nanocarriers. After oral administration, ED‐71‐loaded (ME‐ED‐71@PCA) promotes osteogenic differentiation bone marrow mesenchymal stem cells reducing intracellular oxidative stress, inhibits osteoclast differentiation. ME‐ED‐71@PCA improves mass in ovariectomized‐mice promoting osteogenesis inhibiting osteoclastogenesis, efficacy is more pronounced than ED‐71 alone. exhibits satisfactory performance due its compared providing new approach re‐establish metabolic homeostasis PMOP.

Language: Английский

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Osteogenic mechanism of chlorogenic acid and its application in clinical practice

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Natural polyphenols may have a role in counteracting oxidative stress, which is associated with aging and several bone-related diseases. Chlorogenic acid (CGA) naturally occurring polyphenolic compound formed by the esterification of caffeic quininic acids osteogenic, antioxidant, anti-inflammatory properties. This review discusses potential CGA to enhance osteogenesis increasing osteogenic capacity mesenchymal stem cells (MSCs), osteoblast survival, proliferation, differentiation, mineralization, as well its ability attenuate osteoclastogenesis enhancing osteoclast apoptosis impeding regeneration. can be involved bone remodeling acting directly on pro-osteoclasts/osteoblasts or indirectly osteoclasts activating nuclear factor kB (RANK)/RANK ligand (RANKL)/acting osteoprotegerin (OPG) system. Finally, we provide perspectives for using treat

Language: Английский

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Cell membrane coated nanoparticles: cutting-edge drug delivery systems for osteoporosis therapy

Nanoscale, Journal Year: 2024, Volume and Issue: 16(17), P. 8236 - 8255

Published: Jan. 1, 2024

The review delves into exploring diverse cellular sources for coating nanoparticles to treat osteoporosis. Furthermore, it highlights the pivotal role of these in restoring immune microenvironment, offering promising avenues combating

Language: Английский

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Association between dietary inflammatory index and osteoporosis in the US population: evidence from NHANES 2003–2010

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Objective This study aimed to explore the association between Dietary Inflammatory Index (DII) and prevalence of osteoporosis in U.S. population, using data from National Health Nutrition Examination Survey (NHANES) 2003–2010. Methods Data 7,290 participants NHANES 2003–2010 survey were analyzed. The relationship DII was evaluated weighted multivariate logistic regression, potential non-linear associations explored through restricted cubic spline (RCS) regression. Subgroup analyses conducted with stratified models, findings depicted a forest plot. To pinpoint key dietary factors associated osteoporosis, we applied least absolute shrinkage selection operator (LASSO) These integrated into nomogram for risk prediction, model’s discriminative ability assessed via receiver operating characteristic (ROC) curve. Results Osteoporosis patients had higher scores than those without condition (1.61 vs. 1.18, p < 0.001). After adjusting covariates, highest quartile an 88% greater (OR: 1.88, 95% CI: 1.41–2.52, P trend <0.001). Restricted analysis confirmed linear risk. showed similar patterns across different groups, as illustrated by LASSO regression identified factors, which used build AUC 83.6%, indicating strong predictive accuracy. Conclusion A is strongly linked increased risk, underscoring importance reducing inflammation help prevent osteoporosis.

Language: Английский

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Dual Functional Hydrogel of Osteoclastic-inhibition and Osteogenic-stimulation for Osteoporotic Bone Defect Regeneration

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101550 - 101550

Published: Feb. 6, 2025

Osteoporotic bone regeneration poses significant challenges due to the complexity of condition. Osteoporosis, a degenerative disorder, results from an imbalance in homeostasis driven by dysregulation osteoblast and osteoclast activity. This complicates treatment osteoporosis its related injuries clinical practice. Despite development various polymer scaffolds for defect repair, achieving effective osteoporotic bones-especially when combined with medications-remains difficult. In this study, we designed drug delivery system composed mesoporous bioactive glass (MBG) photo-crosslinked hyaluronic acid methacrylate (HAMA). system, loaded osteogenesis-promoting peptide DWIVA (D5) osteoclastogenesis-inhibiting alendronate (ALN), is gelled using light initiator 405 nm wavelength light. The MBG@D5-Gel complex enables controlled spatiotemporal release these agents, markedly enhancing conditions within ovariectomized rats inhibiting osteoclastogenesis resorption while promoting osteogenic differentiation mineralization. dual-action synergistically regulates activity, optimizing pathological microenvironment facilitating repair defects. holds great potential as organic-inorganic hybrid biomimetic implant material

Language: Английский

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Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 7, 2025

Ethnopharmacological relevance Eucommia ulmoides , recognized as a traditional Chinese medicinal herb, can tonify liver and kidney strengthen bones muscles. Modern pharmacological research has proved that E. could prohibit the occurrence of osteoporosis arthritis. Aim To investigate effect action mechanism total flavonoids isolated from leaves (TFEL) on bone loss in ovariectomized (OVX) rats, to study its intestinal flora. Materials methods The 3-month-old female rats were randomly divided into six groups: sham operation group, OVX model estradiol TFEL low (TFEL-L) (50), mid (-M) (100) high (-H) (200 mg/kg/d) dose groups. After 13 weeks treatment, sacrificed measure turnover markers, related tissue biochemical indices, microstructure parameters, osteoclastogenesis promotor RANKL inhibitor OPG expression levels. Additionally, fecal samples obtained for high-throughput sequencing analyze Results Oral administration increased serum level formation marker PINP decreased resorption NTX-I. femoral parameters TFEL-M TFEL-H groups significantly improved compared with which also confirmed by H&E histological staining. High-throughput indicated may regulate composition flora microecology. Conclusion prevent no toxic side effects. Meanwhile, increase diversity improve rats.

Language: Английский

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Hybrid Outer Membrane Vesicles with Genetically Engineering for Treatment of Implant‐Associated Infections and Relapse Prevention Through Host Immunomodulation

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Implant‐associated infections (IAIs) are refractory to elimination, and the local immunosuppressive microenvironment (IME) exacerbates therapeutic difficulties, ultimately causing persistence relapse. Therefore, exploring immunostrengthening treatments holds great promise for reversing IME thoroughly eradicating chronic or repetitive infections. Bacterial outer membrane vesicles (OMVs) have emerged as potential immunostimulatory candidates; however, they lack active targeting capabilities cause non‐specific inflammatory side effects. In this study, bone marrow‐derived mesenchymal stem cells (BMSCs) genetically engineered overexpress CXCR4 isolated cell membranes (mBMSC ) hybridization with OMVs derived from Escherichia coli ( E. produce nanovesicles @OMV). The resulting mBMSC @OMV demonstrate excellent marrow capability effectively taken up by macrophages, triggering efficient transition pro‐inflammatory M1 status through TLR/NF‐κB pathway. This alteration promotes innate bactericidal capacity antigen presentation. Subsequent activation of T B inhibition myeloid‐derived suppressor (MDSCs) facilitated in vivo adaptive immunity mouse models. Additionally, boosted memory bacteria‐specific antibody responses. Together, these data highlight eradicate complicated IAIs provide whole‐stage protection against postsurgical relapse, thus marking a significant immunotherapeutic advancement post‐antibiotic era.

Language: Английский

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Recent advances in tailored chitosan-based hydrogels for bone regeneration and repair

Materials Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This paper summarizes the preparation processes of tailored chitosan-based hydrogels, along with their specific applications in bone regeneration, aiming to inspire innovative designs for hydrogels and foster expanded applications.

Language: Английский

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Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 25, 2025

This study aims to investigate the relationship between Systemic Inflammatory Response Index (SIRI) and bone mineral density (BMD) in children adolescents aged 8-19 years. A cross-sectional design was used, utilizing NHANES data from 2011-2016, including 3,205 participants 8 19 Weighted multivariable regression analysis conducted assess association SIRI BMD at lumbar spine, pelvis, trunk, whole body. Additionally, smooth curve fitting applied examine nonlinear BMD, subgroup analyses were performed explore potential interaction effects modifiers. significantly positively correlated with body (p < 0.05). After adjusting for covariates, a one-unit increase ln(SIRI) associated increases of 0.018 g/cm², 0.006 0.005 g/cm² body, respectively. Nonlinear revealed saturation effect more pronounced impact specific threshold values. Subgroup indicated that gender, age, BMI total calcium levels modulated BMD. is adolescents, positive on levels. finding suggests may serve as biomarker assessing risk low density, offering theoretical support prevention intervention health issues such osteoporosis.

Language: Английский

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