Polyphenol‐Copper Derived Self‐Cascade Nanozyme Hydrogel in Boosting Oxygenation and Robust Revascularization for Tissue Regeneration

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: April 25, 2024

Abstract The regeneration of hypoxia‐impaired chronic tissue defects has long been challenging, mainly due to the inefficiency oxygenation and limited biological activity existing oxygen delivery systems in regulating dynamic process. Herein, a novel polyphenol‐copper coordination strategy fabricate bioactive superoxide dismutase‐catalase self‐cascade nanozymes (SalB‐CuNCs) is reported, which can serve as an situ oxygenator induce angiogenesis simultaneously. copper‐phenolic hydroxyl structure SalB‐CuNCs plays critical role promoting enzyme‐like cascade reaction via catechol‐mediated Cu valence state transition substrate capture mechanism. Furthermore, after incorporating into Schiff base hydrogel (COC@SalB‐Cu), resulting system exhibits outstanding antioxidant robust effect mitigating hypoxic microenvironment. Benefiting from intrinsic angiogenic SalB copper, COC@SalB‐Cu more complete tube formation by up‐regulating expression level vascular endothelial growth factor (VEGF), platelet‐endothelial cell adhesion molecule‐1 (CD31), nitric oxide synthase (eNOS). In vivo experiments further demonstrate that significantly restore blood supply, leading fast regeneration. present holds enormous promise for treatment hypoxia‐related injury field regenerative medicine.

Language: Английский

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D‐cysteine‐Derived Carbon Dots for Selective Discrimination, Imaging, and Synergistic Elimination of Gram‐Positive Bacteria and Fungi

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 30, 2024

Abstract Microbial infections pose a significant threat to public health, exacerbated by the escalating issue of antibiotic resistance resulting from their overuse. Chiral carbon dots (CDs) not only inherit antibacterial properties CDs but also demonstrate highly selective chiral bactericidal activity. This study focuses on development synthesized D‐ and L‐cysteine, selectively identify synergistically eradicate Gram‐positive bacteria fungi. exhibit high efficacy in staining fungi while demonstrating minimal no fluorescence with Gram‐negative bacteria, attributable variances membrane structures these pathogens. D‐CDs stronger signals greater against compared L‐CDs. Under dual light irradiation, bolster activity through triple‐modal mechanism, involving disruption absence light, singlet oxygen generation during photodynamic therapy, elevated temperature photothermal treatment. Animal studies additionally showcase that notably enhanced healing wounds infected S. aureus under laser exposure. investigation underscores chiral‐specific imaging potentials D‐CDs, paving way for advancement nanomaterials bacterial diagnostics therapy.

Language: Английский

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Ultrasound-Activated Piezoelectric Heterojunction Drives Nanozyme Catalysis to Induce Bacterial Cuproptosis-Like Death and Promote Bone Vascularization and Osseointegration

Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123249 - 123249

Published: March 6, 2025

Language: Английский

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Chiral nanomaterials in tissue engineering

Nanoscale, Journal Year: 2024, Volume and Issue: 16(10), P. 5014 - 5041

Published: Jan. 1, 2024

A timely review on chiral nanomaterials in tissue engineering, with a discussion their evaluation prior to clinical applications.

Language: Английский

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Near-infrared electrochemiluminescence of defect-rich molybdenum disulfide quantum dots for sensitive bioanalysis

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 478, P. 147397 - 147397

Published: Nov. 15, 2023

Language: Английский

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Perspectives on Protein–Nanoparticle Interactions at the In Vivo Level

Langmuir, Journal Year: 2024, Volume and Issue: 40(15), P. 7781 - 7790

Published: April 4, 2024

The distinct features of nanoparticles have provided a vast opportunity developing new diagnosis and therapy strategies for miscellaneous diseases. Although few nanomedicines are available in the market or translation stage, many important issues still unsolved. When entering body, nanomaterials will be quickly coated by proteins from their surroundings, forming corona on surface, so-called protein corona. Studies shown that has biological implications, particularly at vivo level. For example, they can promote immune system to rapidly clear these outer materials prevent playing designed role therapy. In this Perspective, techniques characterizing protein–nanoparticle interactions critically summarized. Effects nanoparticle properties environmental factors formation, which further regulate fate nanoparticles, highlighted discussed. Moreover, recent progress biomedical application corona-engineered is introduced, future directions yet challenging research area also briefly

Language: Английский

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Crispr Assisted Mos2@Tqd Nanosheets Based Lateral Flow Assay for Dual-Mode and Sensitive Diagnosis of Sars-Cov-2

Published: Jan. 1, 2025

Language: Английский

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Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 1, 2024

Abstract Background Impaired collateral formation is a major factor contributing to poor prognosis in type 2 diabetes mellitus (T2DM) patients with atherosclerotic cardiovascular disease. However, the current pharmacological treatments for improving remain unsatisfactory. The induction of endothelial autophagy and elimination reactive oxygen species (ROS) represent potential therapeutic targets enhancing angiogenesis facilitating formation. This study investigates molybdenum disulfide nanodots (MoS NDs) prognosis. Results Our shows that MoS NDs significantly enhance ischemic tissues diabetic mice, effective blood resupply. Additionally, boost proliferation, migration, tube cells under high glucose/hypoxia conditions vitro. Mechanistically, beneficial effects on not only depend their known scavenging properties ROS (H O , •O - •OH) but also primarily involve molecular pathway, cAMP/PKA-NR4A2, which promotes contributes mitigating damage cells. Conclusions Overall, this investigated specific mechanism by mediated activation highlighted synergy between antioxidation, thus suggesting an economic biocompatible nano-agent dual functions highly preferable promoting context, thus, highlighting potential. Graphical

Language: Английский

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Gold nanoclusters on a silk fibroin scaffold accelerate fibroblast proliferation and improve burn recovery in a mouse burn model

Materials & Design, Journal Year: 2024, Volume and Issue: 244, P. 113221 - 113221

Published: July 30, 2024

Delayed wound healing in skin burn injuries is common owing to inhibition of proliferation caused by excessive inflammation, necrosis, autophagy, and oxidative stress. Gold nanoclusters modified with lipoic acid (AuNCs) exhibited antioxidant anti-inflammatory effects a murine model. However, the impact AuNCs on dermal cell granulation tissue formation remains unclear. We therefore examined their proliferation, cycle, signaling pathways involved. were combined silk fibroin scaffold tested mouse model human fibroblasts vitro. Combined scaffold, 50 nmol/L activated fibroblast differentiation, collagen deposition, angiogenesis, increasing granulation-tissue formation, reducing necrosis systemic inflammatory response, improving The increased PI3K/Akt pathway phosphorylation fibroblasts, upregulating protein expression cyclin A, B, CDK1, which participate G2/M cycle phase, ultimately promoting proliferation. These findings support beneficial healing. suggested that or other vector potential clinical strategy for treatment.

Language: Английский

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A review of molybdenum disulfide-based 3D printed structures for biomedical applications

Journal of Materials Research and Technology, Journal Year: 2024, Volume and Issue: 32, P. 1630 - 1646

Published: Aug. 6, 2024

MoS2 is a substance, highly valued for its two-dimensional nanostructure and diverse physical chemical properties. This review examines the advancements achieved in biomedical applications through integration of molybdenum disulfide (MoS2), state-of-the-art area 3D printing technology. It initially outlines synthesis routes techniques to tailor The explores how properties underpin biological significance, thereby facilitating therapeutic, tissue engineering, biosensing applications. Emphasis placed on emerging printing, assessing potential when combined with produce customized materials purposes. Strategies create foam topologies electrocatalytically active filaments 3D-printed constructs are explained. enhanced mechanical strength, conductivity, therapeutic efficacy observed structures foreshadow new developments healthcare, including advent biocompatible implants regenerative medicine engineering. Further results show innovations have been made areas leveraging printing. These insights, grounded scientific research, medical practices, technological advancements, position as flexible innovative material across various sectors.

Language: Английский

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