Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
20(1), P. 015027 - 015027
Published: Dec. 13, 2024
Abstract
Carbon
quantum
dots
(CQDs)
have
been
developed
into
a
popular
nanomaterial
due
to
their
abundant
surface
state,
good
biocompatibility,
and
excellent
antimicrobial
properties.
However,
CQDs
with
multiple
functions,
such
as
being
red-emitting,
having
antibacterial
activity,
pH
sensitivity,
rarely
reported.
In
this
work,
red-emitting
(R-CQDs)
optical
properties
activity
were
prepared
by
simple
green
hydrothermal
method.
applications,
the
R-CQDs
featured
generation
of
reactive
oxygen
species,
indicating
photodynamic
ability.
addition,
showed
fine
giving
them
potential
sensors
monitor
wounds
in
real
time.
The
promising
application
for
cell
imaging
was
also
demonstrated.
summary,
we
offer
sensitivity
monitoring
wounds,
shedding
light
on
biomedical
field.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(29)
Published: July 22, 2024
Reactive
oxygen
species
(ROS),
as
metabolic
byproducts,
play
pivotal
role
in
physiological
and
pathological
processes.
Recently,
studies
on
the
regulation
of
ROS
levels
for
disease
treatments
have
attracted
extensive
attention,
mainly
involving
ROS-induced
toxicity
therapy
mediated
by
producers
antioxidant
scavengers.
Nanotechnology
advancements
led
to
development
numerous
nanomaterials
with
ROS-modulating
capabilities,
among
which
carbon
dots
(CDs)
standing
out
noteworthy
nanomedicines
own
their
distinctive
physicochemical
properties,
high
stability,
excellent
biocompatibility.
Despite
progress
treating
ROS-related
diseases
based
CDs,
critical
issues
such
rational
design
principles
remain
underexplored.
The
primary
cause
these
may
stem
from
intricate
amalgamation
core
structure,
defects,
surface
states,
inherent
poses
challenges
establishing
a
consistent
generalization.
This
review
succinctly
summarizes
recently
ROS-modulated
approaches
using
CDs
treatment.
Specifically,
it
investigates
established
therapeutic
strategies
CDs-regulated
ROS,
emphasizing
interplay
between
intrinsic
structure
generation
or
scavenging
ability.
conclusion
raises
several
unresolved
key
scientific
prominent
technological
bottlenecks,
explores
future
perspectives
comprehensive
CDs-based
therapy.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 16, 2024
Abstract
Circularly
polarized
luminescence
(CPL)
has
numerous
applications
in
optical
data
storage,
quantum
computing,
bioresponsive
imaging,
liquid
crystal
displays,
and
backlights
three‐dimensional
(3D)
displays.
In
addition
to
their
competitive
properties,
carbon
dots
(CDs)
benefit
from
simple
low‐cost
preparation,
facile
post‐modification,
excellent
resistance
photo‐
chemical
bleaching
after
carbonization.
Combining
the
superior
performance
with
polarization
peculiarities
through
hierarchical
structure
engineering
is
imperative
for
development
of
CDs.
this
study,
hydrophobic
interactions
aromatic
ligands,
which
participate
surface‐ligand
post‐modification
process
on
ground‐state
chiral
core,
are
employed
drive
oriented
assembly.
Furthermore,
residual
amides
CDs
form
multiple
hydrogen
bonds
during
gradual
aggregation,
causing
assembled
materials
an
asymmetric
bending
structure.
Superficial
ligands
interfere
dynamics
exciton
radiation
transition
stabilize
excited
state
achieve
a
circularly
signal.
The
linkage
overcome
frequent
aggregation‐induced
quenching
phenomenon
that
present
difficulties
conventional
CDs,
facilitate
assembly
self‐supporting
films,
improve
expression.
full‐color
white
CPL
manipulated
by
simply
adjusting
functional
groups
also
illustrates
versatility
strategy.
Finally,
large
flexible
films
multicolor
light‐emitting
diodes
based
stable
powder
phosphors
were
constructed,
thereby
providing
feasible
technical
support
3D
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Arginine
(Arg)
is
involved
in
tissue
metabolism
and
regulates
the
immune
function;
thereby,
achieving
detection
of
Arg
crucial
for
early
diagnosis
treatment
diseases.
Herein,
dual
ratiometric
fluorescence
sensors
were
prepared
with
blue
emission
levorotatory/dextrorotatory
carbon
dots
(CDs)
red
porphyrin
(L/D-CDs-PP)
sensitive
portable
Arg.
Interestingly,
L-CDs-PP
D-CDs-PP
displayed
not
only
peaks
at
493
650
nm
but
also
different
response
modes
to
Arg;
thus,
they
could
serve
as
achieve
accurate
reliable
Arg,
limit
23.87
μM
2.39
D-CDs-PP.
Importantly,
solid-state
successfully
achieved
dual-mode
visual
support
a
smartphone
platform.
In
addition,
exhibited
excellent
biocompatibility
cell
imaging
capabilities,
cells
biological
samples
urine
rat
plasma.
Therefore,
broad
application
prospects
fields
analytical
sensing,
imaging,
medical
diagnosis.
Biomaterials Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Wound
healing
is
a
complex
and
dynamic
process
often
accompanied
by
bacterial
infection,
inflammation,
excessive
oxidative
stress.
Single-atom
nanozymes
with
multi-enzymatic
activities
show
significant
potential
for
promoting
the
of
infected
wounds
modulating
their
antibacterial
anti-inflammatory
properties
in
response
to
wound's
physiological
environment.
In
this
study,
we
synthesized
MN4
single-atom
that
intelligently
respond
pH
value
changes
wound
process.
vitro
experiments
confirm
effectiveness
against
Gram-negative
bacteria,
attributed
elevated
reactive
oxygen
species
(ROS)
accumulation
within
cells.
Moreover,
full-thickness
skin
wound-infected
model
demonstrates
accelerate
repair
regeneration
suppressing
expression
tumor
necrosis
factor-alpha
(TNF-α),
angiogenesis,
enhancing
collagen
deposition.
vivo
biocompatibility
further
demonstrate
favorable
these
nanozymes,
highlighting
clinical
applications
healing.
These
different
microenvironments
may
be
suitable
addressing
variable
diseases.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
Bacterial
infections
and
tumor
tissues
are
characterized
by
complex
microenvironments
with
uneven
oxygen
availability.
Effective
photodynamic
therapy
for
these
conditions
requires
photosensitizers
that
can
perform
optimally
within
such
environments,
specifically
generating
both
type
I
II
reactive
species
(ROS)
simultaneously.
Carbon
dots
(CDs),
a
of
fluorescent
nanomaterial
smaller
than
10
nm,
commonly
used
to
treat
bacterial
tumors.
However,
their
current
limitations,
as
short
maximum
absorption
emission
wavelengths,
significantly
restrict
therapeutic
efficacy
in
deep
tissues.
In
response
challenges,
new
carbon
near‐infrared
(NIR)
properties
is
reported,
featuring
peak
beyond
700
nm
(NIR‐I
region).
These
CDs
offer
strong
tissue
penetration
reduced
advantages.
Additionally,
bromine
atom
doping
enhances
the
generation
ROS
through
efficient
processes.
vitro
studies
demonstrated
high
antibacterial
antitumor
applications.
Ultimately,
findings
translate
into
significant
effectiveness
treating
skin
tumors
vivo.
This
study
employs
bromine‐doped
nanomaterials,
which
demonstrate
fluorescence
NIR
region,
achieve
treatment
ablation
microenvironments.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
The
increasing
challenge
of
antibiotic
resistance
necessitates
the
development
novel
antibacterial
strategies.
In
this
study,
a
kind
self‐capped
carbon
dots
is
synthesized
from
methylene
blue
(MB)
and
cetyltrimethylammonium
chloride
(CTAC),
named
as
MC‐CDs
that
are
specifically
designed
for
enhanced
photodynamic
activity.
Under
660
nm
laser
irradiation,
demonstrate
high
inactivation
rates
Escherichia
coli
(96.83%)
Staphylococcus
aureus
(94.44%)
at
14
18
µg
mL
−1
effectively,
disrupting
bacterial
cell
membranes.
incorporation
zinc
cations
(Zn
2+
)
doping
further
enhances
potential
MC‐CDs,
enabling
substantial
efficacy
even
in
absence
light
due
to
improved
electrostatic
interactions
with
comparison
commercial
agents
such
salicylic
acid,
p
‐chloro‐
m
‐xylenol,
triclosan,
Zn@MC‐CDs
exhibit
superior
performance.
When
formulated
into
hand
sanitizer,
maintained
over
90%
efficacy,
displaying
excellent
stability
extremely
low
cytotoxicity,
highlighting
their
safe
effective
use
personal
hygiene
products.
This
study
introduces
dot
promising
agent,
addressing
critical
need
advanced
reliable
solutions
infection
control.
