Opportunities and challenges of nanomaterials in wound healing: Advances, mechanisms, and perspectives

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153640 - 153640

Published: July 1, 2024

Language: Английский

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Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 165 - 165

Published: Feb. 6, 2025

Healthcare-associated infections pose a significant global health challenge, negatively impacting patient outcomes and burdening healthcare systems. A major contributing factor to healthcare-associated is the formation of biofilms, structured microbial communities encased in self-produced extracellular polymeric substance matrix. Biofilms are critical disease etiology antibiotic resistance, complicating treatment infection control efforts. Their inherent resistance mechanisms enable them withstand therapies, leading recurrent increased morbidity. This review explores development biofilms their dual roles disease. It highlights structural protective functions EPS matrix, which shields populations from immune responses antimicrobial agents. Key molecular biofilm including restricted penetration, persister cell dormancy, genetic adaptations, identified as barriers effective management. implicated various clinical contexts, chronic wounds, medical device-associated infections, oral complications, surgical site infections. prevalence hospital environments exacerbates challenges underscores urgent need for innovative preventive therapeutic strategies. evaluates cutting-edge approaches such DNase-mediated disruption, RNAIII-inhibiting peptides, DNABII proteins, bacteriophage nanoparticle-based solutions, coatings, lock therapies. also examines associated with biofilm-related diagnostic difficulties, disinfectant economic implications. emphasizes multidisciplinary approach importance understanding dynamics, role pathogenesis, advancements strategies combat biofilm-associated effectively settings. These insights aim enhance reduce burden diseases.

Language: Английский

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Polylactic Glycolic Acid-Mediated Delivery of Plectasin Derivative NZ2114 in Staphylococcus epidermidis Biofilms

Antibiotics, Journal Year: 2024, Volume and Issue: 13(3), P. 228 - 228

Published: Feb. 29, 2024

Antimicrobial peptides (AMPs) are antibiotic candidates; however, their instability and protease susceptibility limit clinical applications. In this study, the polylactic acid–glycolic acid (PLGA)–polyvinyl alcohol (PVA) drug delivery system was screened by orthogonal design using double emulsion–solvent evaporation method. NZ2114 nanoparticles (NZ2114-NPs) displayed favorable physicochemical properties with a particle size of 178.11 ± 5.23 nm, polydispersity index (PDI) 0.108 0.10, ζ potential 4.78 0.67 mV, actual drug-loading rate 4.07 0.37%, encapsulation 81.46 7.42% cumulative release 67.75% (120 h) in PBS. The results showed that PLGA increased HaCaT cell viability 20%, peptide retention 50% serum 24.12%, trypsin tolerance 4.24-fold. Meanwhile, vitro antimicrobial assays NZ2114-NPs had high inhibitory activity against Staphylococcus epidermidis (S. epidermidis) (4–8 μg/mL). Colony counting confocal laser scanning microscopy (CLSM) confirmed were effective reducing biofilm thickness bacterial population S. G4 99% bactericidal persister bacteria, which significantly better than free NZ2114. conclusion, demonstrated can be used as reliable for treatment infections caused epidermidis.

Language: Английский

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Quantum dots: a next generation approach for pathogenic microbial biofilm inhibition; mechanistic insights, existing challenges, and future potential

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(4)

Published: March 13, 2024

Language: Английский

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A Porphyrin-Based Metal–Organic Framework Nanozyme with Superior Peroxidase-like Activity for Combating Antibacterial Infections and Promoting Wound Healing

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

As an antibacterial agent, H2O2 is widely used to combat pathogenic bacterial infections clinically. To mitigate potential side effects associated with a high dosage of H2O2, it pivotal improve its efficacy. Herein, nanoscale porphyrin-based mesoporous metal-organic framework (MOF) nanozyme, Nano-PCN-222(Fe), was readily prepared by one pot. Nano-PCN-222(Fe) shows striking peroxidase (POD)-like activity comparable that natural enzyme horse radish peroxidase. Such POD-like nanozyme primarily attributed both the monodispersion and accessibility single-atom catalytic sites Fe within framework. consequence ability effectively catalyze decomposition into more toxic hydroxyl radicals, excellent against Gram-negative (Escherichia coli) Gram-positive (Staphylococcus aureus) bacteria assistance H2O2. Remarkably, only 10 mM sufficient fully kill E. coli S. aureus in presence (10 ppm), which significantly lower than actual clinical disinfection (166-1000 mM). Moreover, could accelerate infected wound healing due superior antimicrobial activity. Additionally, no appreciable biotoxicity observed even though up 30 ppm.

Language: Английский

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Frustrating the Serenity of Bacterial Biofilms by Bristly Reduced Graphene Oxide Sheets

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 26, 2025

Language: Английский

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Advanced biomaterials for targeting mature biofilms in periodontitis therapy

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

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Design and application of antimicrobial nanomaterials in the treatment of periodontitis

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 5, 2025

Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy scaling root planning periodontitis promising strategy. However, this administration method's effectiveness constrained complexity environment. Nanomaterials have demonstrated significant potential antibacterial treatment periodontitis, attributed their controllable size, shape, surface charge, high design flexibility, reactivity, specific area. In review, we summarize complex microenvironment difficulties explicitly reviewing application strategies nanomaterials with unique properties distinct periodontitis. Furthermore, review discusses limitations current research, proposes feasible solutions, explores prospects for using context.

Language: Английский

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Gold nanocage-carbon nanodot composites activate ornidazole against biofilm infections through modulating the hypoxic microenvironment

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 106222 - 106222

Published: March 1, 2025

Language: Английский

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Alleviation of mycobacterial infection by impairing motility and biofilm formation via natural and synthetic molecules

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(4)

Published: March 28, 2025

Language: Английский

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