International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1556 - 1556
Published: Jan. 26, 2024
Current
cytokine-based
natural
killer
(NK)
cell
priming
techniques
have
exhibited
limitations
such
as
the
deactivation
of
biological
signaling
molecules
and
subsequent
insufficient
maturation
population
during
mass
cultivation
processes.
In
this
study,
we
developed
an
amphiphilic
trigonal
1,2-distearoyl-sn-glycero-3-phosphorylethanolamine
(DSPE)
lipid-polyethylene
glycol
(PEG)
material
to
assemble
NK
clusters
via
multiple
hydrophobic
lipid
insertions
into
cellular
membranes.
Our
conjugate-mediated
ex
vivo
sufficiently
augmented
structural
modulation
clusters,
facilitated
diffusional
signal
exchanges,
finally
activated
with
clusters.
Without
any
inhibition
in
exchanges
intrinsic
proliferative
efficacy
cells,
effectively
prime
produced
increased
interferon-gamma,
especially
early
culture
periods.
conclusion,
present
study
demonstrates
that
our
novel
conjugates
could
serve
a
promising
alternative
for
future
production.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 26, 2024
CD44
is
a
ubiquitous
leukocyte
adhesion
molecule
involved
in
cell-cell
interaction,
cell
adhesion,
migration,
homing
and
differentiation.
can
mediate
the
interaction
between
leukemic
stem
cells
surrounding
extracellular
matrix,
thereby
inducing
cascade
of
signaling
pathways
to
regulate
their
various
behaviors.
In
this
review,
we
focus
on
impact
CD44s/CD44v
as
biomarkers
leukemia
development
discuss
current
research
prospects
for
CD44-related
interventions
clinical
application.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 23, 2024
Abstract
Hyaluronic
acid
(HA)
is
a
naturally
occurring
polysaccharide
found
in
the
extracellular
matrix
with
broad
applications
disease
treatment.
HA
possesses
good
biocompatibility,
biodegradability,
and
ability
to
interact
various
cell
surface
receptors.
Its
wide
range
of
molecular
weights
modifiable
chemical
groups
make
it
an
effective
drug
carrier
for
delivery.
Additionally,
overexpression
specific
receptors
on
surfaces
many
states
enhances
accumulation
drugs
at
pathological
sites
through
receptor
binding.
In
this
review,
modification
drugs,
major
proteins,
latest
advances
receptor‐targeted
nano
delivery
systems
(DDS)
treatment
tumors
inflammatory
diseases
are
summarized.
Furthermore,
functions
varying
vivo
selection
methods
different
discussed.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1959 - 1971
Published: Feb. 20, 2024
Triple-negative
breast
cancer
(TNBC)
presents
treatment
challenges
due
to
a
lack
of
detectable
surface
receptors.
Natural
killer
(NK)
cell-based
adaptive
immunotherapy
is
promising
because
the
characteristic
anticancer
effects
killing
malignant
cells
directly
by
secreting
cytokines
and
lytic
granules.
To
maximize
recognition
ability
NK
cells,
biomaterial-mediated
ex
vivo
cell
engineering
has
been
developed
for
sufficient
membrane
immobilization
tumor-targeting
ligands
via
hydrophobic
anchoring.
In
this
study,
we
optimized
amphiphilic
balances
coating
materials
composed
CD44-targeting
hyaluronic
acid
(HA)-poly(ethylene
glycol)
(PEG)-lipid
improve
TNBC
effect.
Changes
in
modular
design
our
material
differentiating
hydrophilic
PEG
length
incorporating
lipid
amount
into
HA
backbones
precisely
regulated
nature
HA-PEG-lipid
conjugates.
The
biomaterial
demonstrated
improved
anchoring
membranes
facilitating
presentation
level
onto
surfaces.
This
led
enhanced
targeting
increasing
formation
immune
synapse,
thereby
augmenting
capability
specifically
toward
CD44-positive
cells.
Our
approach
addresses
solid
tumors
with
deficiency
tumor-specific
antigens
while
offering
valuable
strategy
using
balance
techniques.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(22), P. 28193 - 28208
Published: May 22, 2024
Ferroptosis
therapy
and
immunotherapy
have
been
widely
used
in
cancer
treatment.
However,
nonselective
induction
of
ferroptosis
tumors
is
prone
to
immunosuppression,
limiting
the
therapeutic
effect
To
address
this
issue,
study
reports
a
customized
hybrid
nanovesicle
composed
NK
cell-derived
extracellular
versicles
RSL3-loaded
liposomes
(hNRVs),
aiming
establish
positive
cycle
between
immunotherapy.
Thanks
enhanced
permeability
retention
tumor
homing
characteristics
exosomes,
our
data
indicate
that
hNRVs
can
actively
accumulate
enhance
cellular
uptake.
FASL,
IFN-γ,
RSL3
are
released
into
microenvironment,
where
FASL
derived
from
cells
effectively
lyses
cells.
downregulates
expression
GPX4
tumor,
leading
accumulation
LPO
ROS,
promotes
The
IFN-γ
TNF-α
stimulates
maturation
dendritic
induces
inactivation
GPX4,
promoting
lipid
peroxidation,
making
them
sensitive
indirectly
occurrence
ferroptosis.
This
highlights
role
hNRV
platform
enhancing
effectiveness
synergistic
treatment
with
selective
delivery
inducers
immune
activation
against
glioma
without
causing
additional
side
effects
on
healthy
organs.
OncoTargets and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 87 - 106
Published: Jan. 1, 2025
NK
cells
are
a
type
of
antitumor
immune
cell
with
promising
clinical
application,
following
T
cells.
The
activity
is
primarily
regulated
by
their
surface
receptors
and
microenvironment.
In
gliomas,
the
tumor
microenvironment
exerts
strong
immunosuppressive
effect,
which
significantly
reduces
efficacy
immunotherapy.
Therefore,
this
review
aims
to
discuss
latest
research
on
role
in
glioma
immunotherapy,
focusing
aspects
such
as
development,
function,
localization.
It
summarizes
information
compounds,
monoclonal
antibodies,
cytokine
therapies
targeting
while
emphasizing
current
status
trends
gene-modified
treatment.
Additionally,
it
explores
molecular
mechanisms
underlying
escape
cells,
providing
theoretical
foundation
new
perspectives
for
cell-based
immunotherapy
gliomas.
Biomaterials Research,
Journal Year:
2025,
Volume and Issue:
29
Published: Jan. 1, 2025
Effective
drug
delivery
relies
on
the
selection
of
suitable
carriers,
which
is
crucial
for
protein-based
therapeutics
such
as
tumor
necrosis
factor-related
apoptosis-inducing
ligand
(TRAIL).
One
key
advantages
TRAIL
its
ability
to
selectively
induce
apoptosis
in
cancer
cells
excluding
healthy
tissues
by
binding
death
receptors
DR4
and
DR5,
are
highly
expressed
various
cells.
Despite
this
promise,
clinical
application
has
been
limited
short
half-life,
stability,
inefficient
sites.
To
overcome
currently
available
engineering
approaches,
a
series
sophisticated
strategies
required:
(a)
design
biomaterial-mediated
carriers
enhanced
targeting
efficacy,
particularly
via
optimizing
selected
materials,
composition,
formulation,
surface
modulation.
Moreover,
(b)
development
genetically
modified
cellular
products
augmented
secretion
toward
microenvironments
(c)
cell
techniques
immobilization
onto
infusible
populations
also
discussed
present
review.
Among
these
living
cell-based
offer
distinct
advantage
systemically
administered
TRAIL-functionalized
capturing
circulating
bloodstream,
thereby
preventing
secondary
formation.
This
review
provides
insight
into
novel
platforms,
discusses
considerations
translation,
suggests
future
directions
complementary
advance
field
TRAIL-based
therapeutics.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
convergence
of
nanotechnology
and
cancer
therapeutics
has
opened
new
frontiers
in
the
development
advanced
drug
delivery
systems.
Among
various
nanocarriers,
nanobubbles
offer
significant
potential
due
to
their
unique
properties,
such
as
high
payload
capacity,
responsiveness
external
stimuli
like
ultrasound,
enhanced
permeability
retention
(EPR)
effects.
Functionalizing
these
with
chitosan,
a
naturally
derived
biopolymer
known
for
its
biocompatibility,
biodegradability,
ability
enhance
cellular
uptake,
further
improves
therapeutic
efficacy.
This
review
provides
comprehensive
analysis
synthesis,
functionalization,
application
chitosan-functionalized
therapy.
We
discuss
mechanism
action,
including
targeted
delivery,
ultrasound-mediated
release,
immune
modulation,
alongside
recent
advancements
challenges
clinical
translation.
also
explores
future
directions
this
rapidly
evolving
field,
aiming
insights
into
next-generation
therapeutics.
