Magnetically Induced Anisotropic Microstructures on Polyethylene Glycol Hydrogel Facilitate BMSC Alignment and Osteogenic Differentiation DOI Creative Commons
Hua Zhang, Yang Luo, Rong Xu

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 814 - 814

Published: Dec. 11, 2024

Many tissues exhibit structural anisotropy, which imparts orientation-specific properties and functions. However, recapitulating the cellular patterns found in anisotropic presents a remarkable challenge, particularly when using soft wet hydrogels. Herein, we develop self-assembled magnetic Fe3O4 micropatterns on polyethylene glycol hydrogels utilizing dipole–dipole interactions. Under influence of static field, nanoparticles align into highly ordered structures with height 400–600 nm width 8–10 μm. Furthermore, our layer-by-layer assembly technique enables creation oriented varying densities heights, can be further manipulated to form three-dimensional by adjusting angle field. These applied various substrates, including treated glass slides, standard silicon wafers, polydimethylsiloxane. The patterned scaffolds, modified gold coating, effectively enhance adhesion, orientation, osteogenic differentiation bone marrow-derived stem cells, is crucial for effective tissue repair. Overall, this study an efficient strategy constructing micropattern hydrogels, providing bioactive platform that significantly enhances

Language: Английский

Cellulose-based aerogels, films, and fibers for advanced biomedical applications DOI

Yaxuan Wang,

Junjie Qi, Meng Zhang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154434 - 154434

Published: July 31, 2024

Language: Английский

Citations

27
Artificial Cell Wall: From Maintenance of Cell Viability to Boosting New Cellular Functionalities† DOI Open Access
Haoxiang Yuan, Xin Qiao, Shangsong Li

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Comprehensive Summary Artificial cell wall (ACW) referring to active functional cellular nano‐coatings is capable of providing more cell‐shell synergic and cooperative properties than conventional single nanoencapsulation (SCNE). With the development SCNE, issues cytocompatibility, degradability, etc ., have already been improved successively. However, further emphasis on cooperativity between itself its shell still missing paying attention functions hybrids. Recent research proved that construction nano‐coating cells not only needs satisfy functionalization cells, but also necessary empower interact with other environments. This indicates SCNEs are tending be “active” participate in metabolic process gradually develop stage ACWs. review provided a reasonable description artificial wall, realization this concept requires cooperativity, self‐adaption fluxionality. Then, methodologies constructing ACWs were discussed. Finally, applications summarized accompanied by potential outlook given fields. Key Scientists Within recent ten years, fabricating biocompatible surface for cyto‐protection rapidly developed. For example, Rawil F. Fakhrullin Yuri M. Lvov developed ‘layer‐by‐layer’ strategy construct ‘face‐lifting’ micro‐organisms. Afterwards, Choi introduced ‘artificial spore’ which thin tough encapsulations. At same time, Tsukruk hydrogel‐based terms 2013. In 2016, Tang reported biomimetic mineralization can used improve modify metabolism processes cells. More advanced, Qu Hawker separately way introduce manganese dioxide nanozymes in‐situ ‐grafting polymers realize responsive effects towards regulation 2017. 2018, Huang showed generate type heritable based situ self‐assembly coacervate micro‐droplets around yeast 2019, Jeffrey nanoparticles adopted exoskeletons outside endow new forming ‘supracells’. put forward concepts ‘active shell’ ‘dynamic indicated nanoencapsulations was beginning transition control fate degradable walls 2020 an intracellular method regulate algae promote hydrogen production. Based his previous research, focused introducing fabrication wall’.

Language: Английский

Citations

1
Nanofibrous Scaffolds in Biomedicine DOI Open Access
Hossein Omidian, Erma J. Gill

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(7), P. 269 - 269

Published: July 12, 2024

This review explores the design, fabrication, and biomedical applications of nanofibrous scaffolds, emphasizing their impact on tissue engineering regenerative medicine. Advanced techniques like electrospinning 3D printing have enabled precise control over scaffold architecture, crucial for mimicking native structures. Integrating bioactive materials has significantly enhanced cellular interactions, mechanical properties, controlled release therapeutic agents. Applications span bone, cardiovascular, soft tissue, neural regeneration, wound healing, advanced drug delivery. Despite these advancements, challenges such as scalability, biocompatibility, long-term stability remain barriers to clinical translation. Future research should focus developing smart scaffolds utilizing AI-enhanced manufacturing more personalized effective therapies.

Language: Английский

Citations

6
Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge‐Like Framework and Cell Guidance DOI Creative Commons
Si Meng,

Nihuan Wu,

Jie Fang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Engineering hollow fibers with precise surface microstructures is challenging; yet, essential for guiding cells alignment and ensuring proper vascular tissue function. Inspired by Euplectella sponges, a novel strategy to engineer biomimetic spiral developed. Using oxidized bacterial cellulose, polydopamine, "brick-and-mortar" scaffold created through shear control during microfluidic coaxial spinning. The mimics natural extracellular matrices, providing mechanical stability supporting cell growth. In vitro studies show successful co-culture of endothelial (ECs) smooth muscle (SMCs), SMCs aligning along ECs forming confluent inner layer. vivo implantation confirms biocompatibility, biodegradability, low immunogenicity. This Euplectella-inspired presents promising approach engineering regenerative medicine.

Language: Английский

Citations

0
Recent Development of Fibrous Hydrogels: Properties, Applications and Perspectives DOI Creative Commons
Wen Luo,

Liujiao Ren,

Bin Hu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Fibrous hydrogels (FGs), characterized by a 3D network structure made from prefabricated fibers, fibrils and polymeric materials, have emerged as significant materials in numerous fields. However, the challenge of balancing mechanical properties functions hinders their further development. This article reviews main advantages FGs, including enhanced properties, high conductivity, antimicrobial anti-inflammatory stimulus responsiveness, an extracellular matrix (ECM)-like structure. It also discusses influence assembly methods, such fiber cross-linking, interfacial treatments fibers with hydrogel matrices, supramolecular assembly, on diverse functionalities FGs. Furthermore, mechanisms for improving performance above five aspects are discussed, creating ion carrier channels situ gelation drugs to enhance antibacterial entanglement hydrophobic interactions between resulting ECM-like structured In addition, this review addresses application FGs sensors, dressings, tissue scaffolds based synergistic effects optimizing performance. Finally, challenges future applications providing theoretical foundation new insights design cutting-edge

Language: Английский

Citations

2
Research progress of eco-friendly plant-derived biomass-based wood adhesives: A review DOI
Minmin Chang, Peng Shen, Lijun Wang

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 222, P. 120093 - 120093

Published: Nov. 19, 2024

Language: Английский

Citations

2
Magnetically Induced Anisotropic Microstructures on Polyethylene Glycol Hydrogel Facilitate BMSC Alignment and Osteogenic Differentiation DOI Creative Commons
Hua Zhang, Yang Luo, Rong Xu

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 814 - 814

Published: Dec. 11, 2024

Many tissues exhibit structural anisotropy, which imparts orientation-specific properties and functions. However, recapitulating the cellular patterns found in anisotropic presents a remarkable challenge, particularly when using soft wet hydrogels. Herein, we develop self-assembled magnetic Fe3O4 micropatterns on polyethylene glycol hydrogels utilizing dipole–dipole interactions. Under influence of static field, nanoparticles align into highly ordered structures with height 400–600 nm width 8–10 μm. Furthermore, our layer-by-layer assembly technique enables creation oriented varying densities heights, can be further manipulated to form three-dimensional by adjusting angle field. These applied various substrates, including treated glass slides, standard silicon wafers, polydimethylsiloxane. The patterned scaffolds, modified gold coating, effectively enhance adhesion, orientation, osteogenic differentiation bone marrow-derived stem cells, is crucial for effective tissue repair. Overall, this study an efficient strategy constructing micropattern hydrogels, providing bioactive platform that significantly enhances

Language: Английский

Citations

1