Extraction of Oleanolic Acid from Olea Europaea L. leaves using a Lipophilic Deep Eutectic Solvent for direct formulation of self-emulsifying drug delivery systems DOI Creative Commons

Antonio Spennacchio,

Giuseppe Francesco Racaniello, Gennaro Balenzano

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106519 - 106519

Published: Dec. 1, 2024

Language: Английский

Oral formulations for highly lipophilic drugs: Impact of surface decoration on the efficacy of self-emulsifying drug delivery systems DOI Creative Commons
Matthias Sandmeier, Julia Hoeng, Sanne Jensen

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 677, P. 1108 - 1119

Published: July 31, 2024

To evaluate the impact of surface decoration cannabidiol (CBD) loaded self-emulsifying drug delivery systems (SEDDS) on efficacy formulations to cross various barriers faced by orally administered drugs.

Language: Английский

Citations

7
Evaluation of the dissociation behavior of hydrophobic ion pairs via HPLC analysis DOI Creative Commons
Daniel Stengel,

Christa Nestl,

Annika Postina

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125311 - 125311

Published: Feb. 1, 2025

The objective of this study was to investigate the stability hydrophobic ion pairs (HIP) tuftsin and perfluorooctanoic acid in physiological media via high performance liquid chromatography (HPLC) METHODS: HIP formed between model peptide (PFOA). Precipitation efficiency logP determined HPLC. characterized mass spectrometry (MS). Furthermore, impact monovalent salts (NaCl, KCl), divalent (CaCl2, MgCl2), phosphate containing (pure phosphate, PBS), bile (sodium taurocholate, sodium deoxycholate) fatty myristate) as well pH on dissociation analyzed a charge ratio 1:1 (tuftsin: PFOA) showed 2512-fold increase lipophilicity compared tuftsin. formation confirmed by spectrometry, showing peak at expected 1327 m/z. Pure eluted from C18 reversed phase column after 1.8 min, while 6.6 min. presence relevant compounds decreased following rank order: deoxycholate > myristate magnesium chloride = calcium taurocholate potassium chloride. lower pH, HIP. HPLC analysis offers valuable method media.

Language: Английский

Citations

0
Design of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells DOI Creative Commons

Dennis To,

Christian Steinbring,

Leonie I. Weber

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113677 - 113677

Published: April 1, 2025

Oral delivery of the proliferation-inhibiting brain acid-soluble protein 1 effector domain peptide (Myr-NT) towards MYC-dependent gastrointestinal tumors can be achieved by forming hydrophobic ion pairs (HIPs) and incorporating them into lipid-based formulations. Hydrophobic pairing fluorescently-labelled Myr-NT (Myr-NT-TAMRA) was performed, increase in lipophilicity assessed, most promising HIP subsequently incorporated a nanoemulsion. Stability degradation trypsin evaluated. Anti-proliferative anti-invasive measurements were performed upon application loaded nanoemulsion on various human cancer cell lines. Cellular uptake molecular effect complementary investigated confocal laser scanning microscopy (CLSM) immunoblot analyses, respectively. HIPs Myr-NT-TAMRA exhibited up to 10,000-fold lipophilicity, thereby enabling incorporation The formulation significantly boosted stability enzymatic trypsin. Furthermore, anti-proliferative lines revealed superior biological activity compared native particularly lymphoma cells, but also colorectal cells. Thereby, correlation with proliferation inhibition as well differences MYC expression observed. Finally, CLSM imaging 15-fold increased cellular from confirming efficient intracellular peptide. efficiently delivered intestinal tumor cells using orally administered

Language: Английский

Citations

0
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations DOI Creative Commons
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Intraoral delivery of active pharmaceutical ingredients (API) is an attractive approach to improve their local therapeutic efficacy or enable systemic delivery. It offers several advantages, such as high drug concentration at the intraoral target site and rapid access circulation due vascularization oral cavity, bypassing first‐pass metabolism. However, limitations need be addressed, relatively short residence time formulations applied in cavity salivation, swallowing reflex, tongue movement, well poor membrane permeability of, particular, hydrophilic drugs. Within this review, a comprehensive summary latest strategies formulation approaches field provided, focusing on those pursued by academia industry overcome challenges. An overview provided excipients that are generally recognized safe (GRAS) utilized enhance systems, mucoadhesive materials, enzyme inhibitors, permeation enhancers. Innovative dosage forms outlined, covering solid, semi‐solid, liquid systems aerosols. Future trends, including self‐emulsifying microneedles, situ bioprinting, explored, presenting new opportunities for

Language: Английский

Citations

0
Advances in the transport of oral nanoparticles in gastrointestinal tract DOI
Tingting Song, Yuan Lü,

Jie Wang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114321 - 114321

Published: Oct. 15, 2024

Language: Английский

Citations

2
Research Progress on Peptide Drugs for Type 2 Diabetes and the Possibility of Oral Administration DOI Creative Commons
Xinxin Yang,

Ruiting Lin,

C Feng

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1353 - 1353

Published: Oct. 23, 2024

Diabetes is a global disease that can lead to range of complications. Currently, the treatment type 2 diabetes focuses on oral hypoglycemic drugs and insulin analogues. Studies have shown such as metformin are useful in but limit liver's ability release sugar. The development glucose-lowering peptides has provided new options for diabetes. Peptide low utilization due their easy degradation, short half-life, difficulty passing through intestinal mucosa. Therefore, improving peptide remains an urgent problem. This paper reviews research progress mellitus proposes different types nano-formulation carriers, liposomes, self-emulsifying drug delivery systems, polymer particles, should be combined with administration improve absorption gastrointestinal tract.

Language: Английский

Citations

0
Extraction of Oleanolic Acid from Olea Europaea L. leaves using a Lipophilic Deep Eutectic Solvent for direct formulation of self-emulsifying drug delivery systems DOI Creative Commons

Antonio Spennacchio,

Giuseppe Francesco Racaniello, Gennaro Balenzano

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106519 - 106519

Published: Dec. 1, 2024

Language: Английский

Citations

0