Journal of Pharmaceutical Investigation, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Language: Английский
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 148 - 148
Published: Jan. 22, 2025
The oral mucosa is a versatile surface for drug administration, supporting both local and systemic therapies. Many active substances are effectively absorbed in the cavity, offering an alternative to enteral administration by bypassing harsh gastrointestinal environment hepatic first-pass metabolism. This has made mucosal delivery growing area of research. Enhancing bioavailability ingredients key focus pharmaceutical technology, especially given challenges developing new drugs. Numerous strategies improve compatible with delivery, unique anatomy cavity enabling specialized applications. A variety dosage forms tailored meet therapeutic needs while addressing biopharmaceutical patient compliance challenges. Proper formulation can achieve controlled release, improved bioavailability, convenience. review highlights potential focusing on enhancement methods types production technologies optimized use cavity.
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 879 - 879
Published: March 25, 2025
Although polyethylene glycol (PEG)-based surfactants are widely used in various industries due to their wide range of hydrophile-lipophile balance (HLB) values, possible by-product, 1,4-dioxane, has been listed as a reasonably anticipated human carcinogen, which may limit applications fields closely related the body. Polyglycerol fatty acid esters (PGFEs), class based on polyglycerol (another polyether), also have HLB values that can be adjust by varying degree polymerization polyglycerol, length carbon chain, or esterification, but do not risks caused 1,4-dioxane. In addition, all raw materials (glycerol and acids) required for preparation PGFEs obtained via hydrolysis renewable vegetable oils. Therefore, PGFEs, new eco-friendly biodegradable non-ionic surfactants, proposed potential green alternatives PEG-based surfactants. This review summarizes properties specifically including HLB, surface properties, phase behaviors, stabilizing effect foams emulsions, stability, highlights food, cosmetics, pharmaceuticals observed last decade.
Language: Английский
Citations
0
International Materials Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 13, 2025
In recent years, zwitterionic materials have been widely used in biomedical and nanomedical due to their unique structure which the molecule is electrically neutral with equal positive negative charge. This kind of material could form a thick hydration layer by electrostatic effect, prevent contamination, show wide applications life science fields, such as resisting non-specific protein adsorption, biofilm, thrombosis formation, so on. Most importantly, diversity functional groups has made it more convenient for surface modification further utilization, creating multifunctional various applications. review summarized up-to-date materials, including conventional novel structural characteristics, well blood-contacting implantable devices, antibacterial coatings, wound dressings, drug-targeted carriers, smart wearable biosensors, especially clinical uses. New discoveries, existing challenges, commercial status are also outlined, future opportunities development perspectives new biomaterials demonstrated.
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137868 - 137868
Published: May 1, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9889 - 9919
Published: Sept. 1, 2024
With the in-depth knowledge of pathological and physiological characteristics intestinal barrier-portal vein/intestinal lymphatic vessels-systemic circulation axis, oral targeted drug delivery is frequently being renewed. many advantages, such as high safety, convenient administration, good patient compliance, researchers have begun to explore from intravenous injections administration. Over past few decades, fields materials science nanomedicine produced various platforms that hold great potential in overcoming multiple barriers associated with delivery. However, transport particles into systemic extremely difficult due immune rejection biochemical invasion intestine, which limits absorption entry bloodstream. The feasibility drugs sites outside gastrointestinal tract (GIT) unknown. This article reviews biological absorption, vivo fate mechanisms carriers, theoretical basis for impact carrier structural evolution on administration achieve this goal. Finally, different nano-delivery systems can enhance bioavailability therapeutics highlights their applications efficient creation anticancer nanomedicines.
Language: Английский
Citations
1
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 20, 2024
This Perspective explores the potential of nonpsychoactive cannabinoids (NPCs) such as CBD, CBG, CBC, and CBN in developing innovative biomaterials for biomedical sports applications. It examines their physicochemical properties, anti-inflammatory, analgesic, neuroprotective effects, integration into various hydrogels, sponges, films, scaffolds. also discusses current challenges standardizing formulations, understanding long-term intrinsical regulatory landscapes. Further, it promising applications NPC-loaded materials bone regeneration, wound management, drug delivery systems, emphasizing improved biocompatibility, mechanical therapeutic efficacy demonstrated
Language: Английский
Citations
1
Journal of Pharmaceutical Investigation, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Language: Английский
Citations
0