A Multifunctional Mitochondria-Protective Gene Delivery Platform Promote Intervertebral Disc Regeneration DOI
Yu Wang, Mingyan Deng, Ye Wu

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123067 - 123067

Published: Dec. 28, 2024

Language: Английский

The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications DOI Creative Commons
Xiang‐Long Chen, Anran Zhang, Kangcheng Zhao

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102323 - 102323

Published: May 9, 2024

Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.

Language: Английский

Citations

24
MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration DOI Creative Commons
Hussein H. Genedy, P. Humbert,

Bilel Laoulaou

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115214 - 115214

Published: Feb. 22, 2024

Language: Английский

Citations

13
Downregulation of VEGFA accelerates AGEs-mediated nucleus pulposus degeneration through inhibiting protective mitophagy in high glucose environments DOI

Depeng Wu,

Weijun Huang, Junbin Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129950 - 129950

Published: Feb. 5, 2024

Language: Английский

Citations

7
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy DOI
Shuhua Yang, Yuxuan Zhu,

Yifeng Shi

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 221, P. 245 - 256

Published: May 26, 2024

Language: Английский

Citations

6
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps DOI
Yingying Lai, Ningning Yang,

Donghao Shi

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 974, P. 176621 - 176621

Published: April 26, 2024

Language: Английский

Citations

5
From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation DOI Creative Commons

Shuhan Yang,

Shaoze Jing,

Shanxi Wang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 30, 2024

Chronic low back pain (LBP) is an increasingly prevalent issue, especially among aging populations. A major underlying cause of LBP intervertebral disc degeneration (IDD), often triggered by (IVD) inflammation. Inflammation the IVD divided into Septic and Aseptic Conservative therapy surgical treatment fail to address root IDD. Recent advances in infection inflammation range from antibiotics small-molecule drugs cellular therapies, biological agents, innovative biomaterials. This review sheds light on complex mechanisms physiological biochemical processes Furthermore, it provides overview recent research developments this area, intending identify novel therapeutic targets guide future clinical strategies for effectively treating IVD-related conditions.

Language: Английский

Citations

4
PRDM1 promotes nucleus pulposus cell pyroptosis leading to intervertebral disc degeneration via activating CASP1 transcription DOI Creative Commons
Cheng Yu, Jianjun Li,

Wenhao Kuang

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Oct. 21, 2024

Intervertebral disc degeneration (IVDD) is a primary contributor to low back pain and poses considerable burden society. However, the molecular mechanisms underlying IVDD remain be elucidated. PR/SET domain 1 (PRDM1) regulates cell proliferation, apoptosis, inflammatory responses in various diseases. Despite these regulatory functions, mechanism of action PRDM1 remains unexplored. In this study, we investigated role progression. The expression nucleus pulposus (NP) tissues NP cells (NPCs) was assessed using western blotting, immunohistochemistry, immunofluorescence. effects on progression were vitro vivo. Mechanistically, mRNA sequencing, chromatin immunoprecipitation, dual-luciferase reporter assays performed confirm that triggered CASP1 transcription. Our study demonstrated for first time substantially upregulated degenerated NPCs. overexpression promoted NPCs pyroptosis by inhibiting mitophagy exacerbating progression, whereas silencing exerted opposite effect. Furthermore, activated transcription, thereby promoting vitro. Notably, reversed To best our knowledge, demonstrate inhibits repressing which may promising new therapeutic target IVDD.

Language: Английский

Citations

4
CREG1 attenuates intervertebral disc degeneration by alleviating nucleus pulposus cell pyroptosis via the PINK1/Parkin-related mitophagy pathway DOI
Yang Zhang,

Deguo Xing,

Yi Liu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113974 - 113974

Published: Jan. 1, 2025

Language: Английский

Citations

0
Fuh@Decm Hydrogel Delays Intervertebral Disc Degeneration Through Macrophage Reprogramming and Antioxidant Properties DOI

Jing Sun,

Linjie Chen, Zhenyu Guo

et al.

Published: Jan. 1, 2025

1.Abstract Key pathological factors contributing to intervertebral disc degeneration (IVDD) include excessive production of reactive oxygen species (ROS), depletion the extracellular matrix (ECM), and an imbalance in M1/M2 macrophage ratio. To address these challenges, we developed a novel bioactive hydrogel (FUH@dECM) by integrating high-concentration fucoidan (FU) with decellularized (dECM). This is designed for situ injection, where it undergoes gelation at site administration, replenishing lost ECM nucleus pulposus cells while gradually releasing FU. In vitro, experiments demonstrated that controlled release FU effectively scavenges ROS, promotes polarization towards M2 phenotype, restores metabolic balance. RNA sequencing analysis revealed antioxidant effects FUH@dECM are primarily mediated through activation FOXO signaling pathway, inhibition NF-κB pathway mitigates inflammatory response. vivo rat model IVDD, this system strong mechanistic alignment physiological processes disc, significantly improving IVDD outcomes maintaining height preserving structural integrity tissue. These results underscore potential as promising therapeutic strategy treatment IVDD.

Language: Английский

Citations

0
Mitochondria Targeting Nanostructures from Enzymatically Degradable Fluorescent Amphiphilic Polyesters DOI
S. Biswas,

Priya Rajdev,

Ankita Banerjee

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

pH-responsive aqueous nanoassembly from a fluorescent neutral polyester selectively targets mitochondria in cancer cells over non-cancerous due to positive charge gain, while similar assemblies cationic polyesters show no such selectivity.

Language: Английский

Citations

0