JACS Au,
Journal Year:
2024,
Volume and Issue:
4(3), P. 903 - 907
Published: March 8, 2024
The
ordered
arrangement
of
nanoparticles
can
generate
unique
physicochemical
properties,
rendering
it
a
pivotal
direction
in
the
field
nanotechnology.
DNA-based
chemical
encoding
has
emerged
as
an
unparalleled
strategy
for
orchestrating
precise
and
controlled
nanoparticle
assemblies.
Nonetheless,
is
often
time-consuming
limited
assembly
efficiency.
In
this
study,
we
developed
rapid
DNA
origami-framed
assisted
by
dynamic
interfaces.
By
assembling
Au
(AuNPs)
onto
origami
with
different
sticky
ends
various
directions,
endowed
them
anisotropic
specific
affinities.
After
AuNPs
supported
lipid
bilayers
freely
diffusing
single-stranded
via
hybridization,
found
that
could
form
larger
assemblies
than
those
3D
solution
within
equivalent
time
frames.
Furthermore,
also
achieved
liposome
employing
aforementioned
strategy.
Our
work
provides
novel
avenue
efficient
across
two-dimensional
interfaces,
which
expected
to
promote
application
sensor
biomimetic
system
construction.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Abstract
DNA‐directed
assembly
has
emerged
as
a
versatile
and
powerful
approach
for
constructing
complex
structured
materials.
By
leveraging
the
programmability
of
DNA
nanotechnology,
highly
organized
photonic
systems
can
be
developed
to
optimize
light‐matter
interactions
improved
diagnostics
therapeutic
outcomes.
These
enable
precise
spatial
arrangement
components,
minimizing
material
usage,
simplifying
fabrication
processes.
nanostructures,
such
origami,
provide
robust
platform
building
multifunctional
devices
with
tailored
optical
properties.
This
review
highlights
recent
progress
in
nanomaterials,
focusing
on
their
applications
therapeutics.
It
provides
an
overview
latest
advancements
field,
discussing
principles
assembly,
strategies
functionalizing
blocks,
innovations
design,
resulting
effects
that
drive
these
developments.
The
also
explores
how
architectures
contribute
diagnostic
applications,
emphasizing
potential
create
efficient
effective
specific
healthcare
needs.
ChemBioChem,
Journal Year:
2024,
Volume and Issue:
25(13)
Published: May 3, 2024
Abstract
Biomarkers
are
crucial
physiological
and
pathological
indicators
in
the
host.
Over
years,
numerous
detection
methods
have
been
developed
for
biomarkers,
given
their
significant
potential
various
biological
biomedical
applications.
Among
these,
system
based
on
functionalized
DNA
origami
has
emerged
as
a
promising
approach
due
to
its
precise
control
over
sensing
modules,
enabling
sensitive,
specific,
programmable
biomarker
detection.
We
summarize
advancements
using
origami,
focusing
strategies
functionalization,
mechanisms
of
recognition,
applications
disease
diagnosis
monitoring.
These
organized
into
sections
type
biomarkers
–
nucleic
acids,
proteins,
small
molecules,
ions
concludes
with
discussion
advantages
challenges
associated
systems
Journal of Materials Chemistry C,
Journal Year:
2024,
Volume and Issue:
12(13), P. 4618 - 4626
Published: Jan. 1, 2024
The
pure
Sn
nanosheets
were
produced
into
nanospheres
under
the
action
of
in-situ
thermal
field,
and
a
heating
experiment
conducted
on
Cu
interface
samples,
thereby
elucidating
limitation
as
solder
material.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(39), P. 51899 - 51915
Published: Sept. 24, 2024
Deoxyribonucleic
acid
(DNA),
a
macromolecule
that
stores
genetic
information
in
organisms,
has
recently
been
gradually
developed
into
building
block
for
new
materials
due
to
its
stable
chemical
structure
and
excellent
biocompatibility.
The
efficient
preparation
functional
integration
of
various
molecular
complexes
composite
based
on
nucleic
skeletons
have
successfully
achieved.
These
versatile
possess
physical
properties
inherent
certain
inorganic
or
organic
molecules
but
are
endowed
with
specific
physiological
functions
by
acids,
demonstrating
unique
advantages
potential
applications
science,
nanotechnology,
biomedical
engineering
recent
years.
However,
issues
such
as
the
production
cost,
biological
stability,
immunogenicity
DNA
presented
some
unprecedented
challenges
application
these
field.
This
review
summarizes
cutting-edge
manufacturing
techniques
DNA-based
composites
discusses
trends,
challenges,
opportunities
future
development
acid-based
materials.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(42), P. 57832 - 57842
Published: Oct. 14, 2024
Localized
surface
plasmon
resonance
(LSPR)
gas
sensitivity
is
introduced
as
a
new
parameter
to
evaluate
the
performance
of
plasmonic
sensors.
A
model
proposed
consider
sensors'
and
decay
length
correlate
LSPR
response,
measured
upon
exchange,
with
an
equivalent
refractive
index
change
consistent
adsorbed
layers.
To
demonstrate
applicability
this
parameter,
ellipsoidal
gold
nanoparticles
(NPs)
arranged
in
densely
packed
hexagonal
lattices
were
fabricated.
The
main
advantages
these
sensors
are
small
tunable
interparticle
gaps
(18-29
nm)
between
(diameters:
72-88
nm),
their
robust
scalable
fabrication
technology
that
allows
well-ordered
arrangement
be
maintained
on
large
(cm
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 14, 2024
To
investigate
the
potential
of
DNA
nanoparticles
(DNPs)
as
carriers
and
adjuvants
for
mRNA
vaccines.
Customized
oligonucleotides
were
assembled
into
tetrahedra
(DNA-TH),
which
subsequently
complexed
with
streptavidin
encoding
green
fluorescent
protein
(GFP).
Various
assays
conducted
to
evaluat
stability
DNPs,
their
cellular
uptake,
immune
activation
potential,
GFP
transcription
efficiency.
P53-mutant
HSC-3
cells
used
establish
a
subcutaneous
xenograft
tumor
model
explore
effects
DNPs
in
disease
model.
The
remained
stable
extracellularly
rapidly
taken
up
by
antigen-presenting
cells.
Compared
naked
mRNA,
statistically
significantly
activated
responses
facilitated
expression
both
vitro
vivo.
Immunization
DNP-GFP
complexes
induced
higher
antibody
titers
compared
mRNA.
demonstrated
good
biocompatibility.
DNP-p53
inhibited
growth
tumors
mice
p53-mutant
cells,
outperforming
p53
blank
control
groups,
significant
difference
(P
<
0.05).
show
promise
improving
vaccine
delivery
efficacy.
Further
optimization
these
could
lead
highly
effective
broad
applications.
Nanoscale Horizons,
Journal Year:
2024,
Volume and Issue:
10(3), P. 537 - 548
Published: Dec. 10, 2024
Realizing
plasmonic
nanogaps
with
a
refractive
index
(n
=
1)
environment
in
metallic
nanoparticle
(NP)
structures
is
highly
attractive
for
wide
range
of
applications.
So
far
self-assembly-based
approaches,
without
surface
functionalization
NPs,
achieving
such
extremely
small
challenging.
Surface
introduces
changes
the
at
nanogaps,
which
turn
deteriorates
desired
properties.
In
addition,
fabrication
low-density
dimer
NP
designs
smaller
poses
big
challenge.
Here,
we
introduce
simple
and
straightforward
strategy
low-density,
isolated
gold
nanoparticles
nano-particle-on-metallic-mirror
(NPoM)
platform.
A
minimum
interparticle
gap
distance
between
NPs
∼3
nm
achieved
functionalization.
This
possible
by
utilizing
M13
bacteriophage
as
spacer
layer
instead
SiO2
NPoM.
Density
functional
theory
calculations
on
Au
atom
adsorption
constituents
trace
assembly
latter
to
comparatively
weak
interaction
substrate.
Our
study
offers
an
route
fabricating
low
density
featuring
will
enrich
structure
specific/isolated
studies
benefitting
variety
optical,
actuator,
sensing
